CANCER_CELL

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  • 期刊=Signal Transduction and Targeted Therapyx
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Cancer cell employs a microenvironmental neural signal transactivating nucleus-mitochondria coordination to acquire stemness被引量：1
《Signal Transduction and Targeted Therapy》2023年第8期3818-3836,共19页Bin He Rui Gao Shasha Lv Ailin Chen Junxiu Huang Luoxuan Wang Yunxiu Feng Jiesi Feng Bing Liu Jie Lei Bing Deng Bin He Bai Cui Fei Peng Min Yan Zifeng Wang Eric W-F Lam Bilian Jin Zhiming Shao Yulong Li Jianwei Jiao Xi Wang Quentin Liu 
This research work was supported by the National Key R&D Program of China(2019YFA0110300 to Q.L.);the National Natural Science Foundation of China(No.82003096 to R.G.,No.82002943 to B.H.,No.81820108024 to Q.L.and No.81972594 to M.Y.);the Natural Science Foundation of Guangdong(2017A030313608 to Q.L.);the Science and Technology Planning Project of Guangzhou(201804020044 to Q.L.).
Cancer cell receives extracellular signal inputs to obtain a stem-like status,yet how tumor microenvironmental(TME)neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive...
关键词：Cancer neural ARCHITECTURES 
Redox signaling-governed drug-tolerant persister cancer cell:a key spark of treatment failure
《Signal Transduction and Targeted Therapy》2022年第4期955-957,共3页Liwu Fu Zhe-Sheng Chen 
In a recent study published in EMBO Molecular medicine,Zhang et al.provided a novel insight regarding better knowledge of the drug resistant contribution of drug-tolerant persister(DTP)state in tumor evolution,especia...
关键词：cancer HOMEOSTASIS INSIGHT 
Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma被引量：5
《Signal Transduction and Targeted Therapy》2021年第10期3045-3061,共17页Jiajun Xie Zifeng Wang Wenjun Fan Youping Liu Fang Liu Xiangbo Wan Meiling Liu Xuan Wang Deshun Zeng Van Wang Bin He Min Yan Zijian Zhang Mengjuan Zhang Zhijie Hou Chunli Wang Zhijie Kang Wenfeng Fang Li Zhang Eric W-F Lam Xiang Guo Jinsong Yan Yixin Zeng Mingyuan Chen Quentin Liu 
supported by National Key R&D Program of China(2019YFA0110300,2017YFA0505600-04 to Q.L.);Innovative Research Team in University of Ministry of Education of China(IRT_17R15 to Q.L.);National Natural Science Foundation of China(81630005,81573025 to Q.L.,81773166 to Z.W.,81702683 to J.X.,81972594 to M.Y.,81402445 to C.W.,81502579 to Z.H.);Natural Science Foundation of Guangdong(2017A030313608 to Q.L,2018A0303130299,2020A1515010608 to M.Y.);the Science and Technology Planning Project of Guangzhou(201804020044 to Q.L.);the Key Project of Liaoning Natural Science Funding of China(201702031 to Q.L.);Fundamental Research Funds for the Central Universities(I9ykpy187 to M.Y.).EW-FL's work is supported by MRC(MR/N012097/1);CRUK(Al 2011);Breast Cancer Now(2012MayPR070,2012NovPhD016);the Cancer Research UK Imperial Centre,Imperial ECMC,and NIHR Imperial BRC.
Application of differentiation therapy targeting cellular plasticity for the treatment of solid malignancies has been lagging.Nasopharyngeal carci noma(NPC)is a distinctive cancer with poor differe ntiatio n and high ...
关键词：LMP1 cancer PLASTICITY 
PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma被引量：7
《Signal Transduction and Targeted Therapy》2021年第3期1033-1045,共13页Ning Wang Hor-Yue Tan Yuanjun Lu Yau-Tuen Chan Di Wang Wei Guo Yu Xu Cheng Zhang Feiyu Chen Guoyi Tang Yibin Feng 
supported by the Research Council of the University of Hong Kong(project codes:104004092 and 104004460);the Wong’s donation(project code:200006276);a donation from the Gaia Family Trust of New Zealand(project code:200007008);the Research Grants Committee(RGC)of Hong Kong,HKSAR(Project Codes:740608,766211,17152116,and 17121419);Enhanced new staff startup fund(Project code:204610519);868Preemptive retention fund(Project code:202007002);Health and Medical Research Fund(Project code:15162961,16172751).
Altered energy metabolism of cancer cells shapes the immune cell response in the tumor microenvironment that faclitates tumorprogression.Herein,we reported the novel of tumor cell-expressed Piwi Like RNA-Mediated Gene...
关键词：METABOLISM MICROENVIRONMENT HEPATOCELLULAR 
Regulation of cancer cell metabolism:oncogenic MYC in the driver’s seat被引量：8
《Signal Transduction and Targeted Therapy》2020年第1期1419-1429,共11页Yang Dong Rongfu Tu Hudan Liu Guoliang Qing 
supported by the National Science Fund for Distinguished Young Scholars(Grant 81725013 to G.Q.);the National Natural Science Foundation of China(Grant 81830084 to G.Q);the Fundamental Research Funds for the Central Universities(Grant 2042020kf0215);Medical Science Advancement Program(Basic Medical Sciences)of Wuhan University(Grant TFJC2018005 to G.Q.).
Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation.As such,most human cancers differ from normal counterpart tissues by a plethora of energetic and metabolic repr...
关键词：METABOLISM CANCER CANCER 
Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism
《Signal Transduction and Targeted Therapy》2020年第1期299-300,共2页Angela M.Otto 
Open Access funding enabled and organized by Projekt DEAL.
Even though the mTOR complex has been known for decades as a nutrient sensor,being thus in focus for drug targeting in metabolic disease and cancer metabolism,it has remained puzzling how it is able to get a sense of ...
关键词：METABOLISM cancer mTORC1 
TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness被引量：12
《Signal Transduction and Targeted Therapy》2019年第1期104-115,共12页Renle Du Wenzhi Shen Yi Liu Wenjuan Gao Wei Zhou Jun Li Shuangtao Zhao Chong Chen Yanan Chen Yanhua Liu Peiqing Sun Rong Xiang Yi Shi Yunping Luo 
This work was supported by the National Natural Science Foundation of China(No.81772974 to Y.Shi,No.1672914 to Y.Luo,and No.81972795 to C.Chen).
TGF-β-induced factor homeobox 2(TGIF2)is a transcription regulator that plays essential roles in the regulation of development and cell fate decisions.Aberrant expression of TGIF family proteins has been observed in ...
关键词：TGIF ADENOCARCINOMA metastasis 
Central role of lactate and proton in cancer cell resistance to glucose deprivation and its clinical translation被引量：7
《Signal Transduction and Targeted Therapy》2017年第1期266-273,共8页Xun Hu Ming Chao Hao Wu 
This work has been supported in part by the China National 973 project(2013CB911303);China Natural Sciences Foundation projects(81470126);the Fundamental Research Funds for the Central Universities,National Ministry of Education,China,to X.H.
Targeting common weaknesses of cancer is an important strategy for cancer therapy.Glucose is a nutrient that maintains essential cellular metabolism,supporting cancer cell survival,growth and proliferation.Depriving g...
关键词：METABOLISM CLINICAL exceptional 
Inhibiting cancer cell hallmark features through nuclear export inhibition被引量：4
《Signal Transduction and Targeted Therapy》2016年第1期91-100,共10页Qingxiang Sun Xueqin Chen Qiao Zhou Ezra Burstein Shengyong Yang Da Jia 
QS is supported by National Natural Science Foundation of China(NSFC),fund number 80502629;EB is supported by NIH R01-DK073639 and CPRIT grants;DJ is a‘Junior One Thousand Talents’program scholar.
Treating cancer through inhibition of nuclear export is one of the best examples of basic research translation into clinical application.Nuclear export factor chromosomal region maintenance 1(CRM1;Xpo1 and exportin-1)...
关键词：ATTRACTIVE LIKELY BENEFIT 
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