CANCER_CELL

作品数：221被引量：567H指数：13
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相关作者：郭鹏曾津芮红兵陈元仲陈炜更多>>
相关机构：西安交通大学医学院第一附属医院北京大学西安交通大学福建医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>
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Cancer cell membrane-camouflaged biomimetic nanoparticles for enhancing chemo-radiation therapy efficacy in glioma
《Journal of Biomedical Research》2025年第1期87-102,共16页Chunming Tang Yanling Wang Min Wu Zhiji Wang Yupeng Zhou Ya Lin Yijun Wang Huae Xu 
supported by the National Natural Science Foundation of China(Grant Nos.82073308 and 82104089)。
Glioblastoma multiforme(GBM)is a highly aggressive and lethal brain tumor with limited treatment options.To improve therapeutic efficacy,we developed a novel multifunctional nanoplatform,GM@P(T/S),comprised of polymer...
关键词：glioblastoma multiforme TEMOZOLOMIDE superparamagnetic iron oxide chemo-radiation therapy cancer cell membrane-coating 
O-linked β-N-acetylglucosaminylation in lung cancer and beyond: A multidimensional perspective
《Chinese Medical Journal》2025年第3期355-357,共3页Jinxiu Jiang Xiaochun Huang Jianguo Feng Li Liu Yulin Liu Jing Jia 
National Natural Science Foundation of China(No.82000052);Sichuan Science and Technology Program(2022YFS0632);joint foundation of Luzhou Government and Southwest Medical University(Nos.2020LZXNYDJ11,2021LZXNYD-J25);
To the Editor:O-linkedβ-N-acetylglucosaminylation(OGlcNAcylation)is a crucial post-translational modification regulated by two enzymes,O-GlcNAc transferase(OGT)and O-GlcNAcase(OGA).Dysregulation of O-GlcNAcylation ha...
关键词：lung cancer TUMORIGENESIS OGT post translational modification o linked n acetylglucosaminylation OGA cancer cell adap disease processes 
Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition
《Chinese Chemical Letters》2025年第1期415-419,共5页Yanfei Liu Yaqin Hu Yifu Tan Qiwen Chen Zhenbao Liu 
funded by the National Natural Science Foundation of China(No.32271464);the Hunan Provincial Natural Science Foundation for Distinguished Young Scholars(No.2022JJ10086);the Innovation-Driven Project of Central South University(No.2020CX048);Hunan Provincial High-Level Health Talents(No.20240304088);Fund of the Hunan Provincial Natural Science Foundation and the Hunan Medical Products Administration(No.2023JJ60501)。
Precise tumor targeting and therapy is a major trend in cancer treatment.Herein,we designed a tumor acidic microenvironment activatable drug loaded DNA nanostructure,in which,we made a clever use of the sequences of A...
关键词：APTAMER I-MOTIF DNA nanostructure Logic gate Drug delivery system 
Cancer cell response to extrinsic and intrinsic mechanical cue:opportunities for tumor apoptosis strategies
《Regenerative Biomaterials》2024年第6期1-19,共19页Jun Shu Huan Deng Yu Zhang Fang Wu Jing He 
supported by the National Natural Science Foundation of China(grant no.31971257);Natural Science Foundation of Sichuan Province(grant no.2022NSFSC0360).
Increasing studies have revealed the importance of mechanical cues in tumor progression,invasiveness and drug resistance.During malignant transformation,changes manifest in either the mechanical properties of the tiss...
关键词：MECHANOTRANSDUCTION cancer cell APOPTOSIS mechanical stimulation anticancer materials 
Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition
《Chinese Chemical Letters》2024年第11期389-394,共6页Yuanzheng Wang Chen Zhang Shuyan Han Xiaoli Kong Changyun Quan Jun Wu Wei Zhang 
supported by grants from Science and Technology Program of Guangzhou,China(No.201804010146);Guangzhou Science and Technology Program City-University Joint Funding Project(No.2023A03J0001)。
Enhancing the active tumor targeting ability and decreasing the clearance of reticuloendothelial system(RES)are important issues for drug delivery systems(DDSs)in cancer therapy.In recent years,cell membrane camouflag...
关键词：Cell membrane camouflage BIOMIMETIC Gelatin nanogel Drug delivery Tumor therapy 
Cancer cell-derived exosomal miRNA induces and reprograms Schwann cells to augment the perineural invasion of salivary adenoid cystic carcinoma
《Chinese Medical Journal》2024年第20期2498-2500,共3页Jinjin Li Chenzhou Wu Nengwen Huang Xianghe Qiao Zhijie Weng Yunkun Liu Yongzhi Wu Wei Li Longjiang Li Bo Li 
supported by the National Natural Science Foundation of China(Nos.82141130 and 82372735);the Joint Project of Medical Science and Technology of Henan Province(No.LHGJ20230308).
To the Editor:Salivary adenoid cystic carcinoma(SACC)is characterized by the high frequency of perineural invasion(PNI)behavior during tumor progression.However,the impact of intercellular communication between SACC c...
关键词：INVASION CANCER SALIVARY 
Communication between cancer cell subtypes by exosomes contributes to nasopharyngeal carcinoma metastasis and poor prognosis
《Precision Clinical Medicine》2024年第3期265-278,共14页Hao-Jun Xie Ming-jie Jiang Ke Jiang Lin-Quan Tang Qiu-Yan Chen An-Kui Yang Hai-Qiang Mai 
supported by grants from the National Key Research and Development Program of China(Grant Nos.2022YFC2505800,2022YFC2705005);the National Natural Science Foundation of China(Grant Nos.32200651,82203776,82203125,82222050,82272739,82272882,82173287,82073003,82003267,82002852);Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2021B1515230002,2022A1515110033);Science and Technology Program of Guangzhou(Grant Nos.202201011561,2023A04J2127);Sun Yat-sen University Clinical Research 5010 Program(Grant Nos.201315,2015021,2017010,2019023);Innovative Research Team of High-level Local Universities in Shanghai(Grant No.SSMU-ZLCX20180500);Postdoctoral Innovative Talent Support Program(Grant No.BX20220361);Planned Science and Technology Project of Guangdong Province(Grant No.2019B020230002);Key Youth Teacher Cultivating Program of Sun Yat-sen University(Grant No.20ykzd24),and Fundamental Research Funds for the Central Universities.
Background:Intratumor heterogeneity is common in cancers,with different cell subtypes supporting each other to become more malignant.Nasopharyngeal carcinoma(NPC),a highly metastatic cancer,shows significant heterogen...
关键词：cell heterogeneity cell communication EXOSOMES METASTASIS nasopharyngeal carcinoma 
Colorectal cancer cell dormancy:An insight into pathways
《World Journal of Gastroenterology》2024年第33期3810-3817,共8页Anil Kumar Lekha Saha 
Cancer cell dormancy(CCD)in colorectal cancer(CRC)poses a significant challenge to effective treatment.In CRC,CCD contributes to tumour recurrence,drug resistance,and amplifying the disease's burden.The molecular mech...
关键词：Colorectal cancer Colorectal cancer cell dormancy Cancer cell dormancy Pathways in colorectal cancer dormancy 
Research Progress on the Bone Metastasis Mechanism of Prostate Cancer and Bone-Targeted Drugs
《Proceedings of Anticancer Research》2024年第4期30-34,共5页Xiaoqing Zhang Bifeng Fu Ruiyu Mu Chunxin Jia Jiayu Li Haibo Xie Si Wu Ping Wang Aifeng Liu Guang Yang Xingyu Jiang 
Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine Research Project of Tianjin Municipal Administration of Traditional Chinese Medicine(2021106);Beijing-Tianjin-Hebei Traditional Chinese Medicine Collaborative Development Specialty Alliance Construction Project(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Qingxian County Traditional Chinese Medicine Hospital).
Prostate cancer is a common male malignant tumor,and bone metastasis is one of the common complications in the late stage of prostate cancer.The mechanism of prostate cancer bone metastasis is a complex process involv...
关键词：Prostate cancer Bone metastasis MECHANISM Bone targeting drugs Cancer cell 
Poly (ADP-ribose): A double-edged sword governing cancer cell survival and death
《World Journal of Clinical Oncology》2024年第7期806-810,共5页Keun-Yeong Jeong Ji-Hyuk Kang 
Poly(ADP-ribose)(PAR),a polymer of ADP-ribose,is synthesized by PAR po-lymerase and is crucial for the survival of cancer cells due to its vital functions in DNA repair and post-translational modifications.Beyond its ...
关键词：ADP-RIBOSE Poly(ADP-ribose) ADP ribosylation PARylation Parthanatos ANTICANCER 
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