CAPILLARY_ELECTROPHORESIS

作品数：174被引量：197H指数：5
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相关机构：北京大学北京理工大学复旦大学首都医科大学附属北京友谊医院更多>>
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Resolving the geometric structure of trastuzumab by mobility capillary electrophoresis and native mass spectrometry
《Chinese Chemical Letters》2024年第3期221-225,共5页Wenjing Zhang Jie Hong Lei Yang Zuqiang Xu Yu Xiang Wei Xu 
supported by Ministry of Science and Technology of the People’s Republic of China instrumentation program(No.2020YFF01014502);NNSFC(No.21827810);Beijing Institute of Technology(No.2021CX006)。
Available online Immunoglobulins G(IgGs)are Y-shaped globular proteins,however,their high flexibility and heterogeneity pose great challenges to their structure and conformation determinations.Geometric structure of I...
关键词：Native mass spectrometry Mobility capillary electrophoresis TRASTUZUMAB Protein structure Geometric structure 
Recent applications and chiral separation development based on stationary phases in open tubular capillary electrochromatography(2019–2022)被引量：1
《Journal of Pharmaceutical Analysis》2023年第4期323-339,共17页Xinyu Li Qianjie Ma Xiangtai Zheng Qin Chen Xiaodong Sun 
This study was funded by the Project of National Natural Science Foundation of China(Grant No.:82003705);the Shanghai Science and Technology Innovation Foundation(Grant Nos.:23010500200 and 23ZR1422700).
Capillary electrochromatography(CEC)plays a significant role in chiral separation via the double separation principle,partition coefficient difference between the two phases,and electroosmotic flow-driven separation.G...
关键词：Capillary electrochromatography Open tubular capillary Chiral separation Stationary phase Capillary electrophoresis with mass spectrometry(CE/MS) 
Developmental validation of the novel six-dye Goldeneye^(TM)DNA ID System 35InDel kit for forensic application被引量：1
《Forensic Sciences Research》2022年第4期673-684,共12页Qi Yang Huan Yu Yiling Qu Xiaochun Zhang Ruocheng Xia Ziwei Wang Rui Tan Lei Xiong Shihan Xi Jun Wu Yuzhen Gao Suhua Zhang Chengtao Li 
This study was supported by grants from the National Youth Top-Notch Talent of Ten Thousand Program[grant number WRQB2019];the Youth Science and Technology Innovation Leader of Ten Thousand Program[grant number 2018RA2102],China.
Insertion/deletion polymorphisms(InDels)have been treated as a prospective and helpful genetic marker in the fields of forensic human identification,anthropology and population genetics for the past few years.In this ...
关键词：Forensic sciences forensic genetics insertion and deletion polymorphism(InDel) 35InDel kit developmental validation capillary electrophoresis(CE) 
Next generation sequencing of Y-STRs in father-son pairs and comparison with traditional capillary electrophoresis
《Forensic Sciences Research》2022年第3期484-489,共6页Steffi Bredemeyer Lutz Roewer Sascha Willuweit 
supported by the Internal Security Funding Police Program of the European Commission-Directorate General Migration;Home Affairs under the European Commission[grant number HOME/2014/ISFP/AG/LAWX/4000007135].
To evaluate the promising advantages of massively parallel sequencing(MPS)in our casework,we analysed a total of 33 Y-chromosomal short tandem repeats(Y-STRs)with traditional capillary electrophoresis(CE)and 25 Y-STRs...
关键词：Forensic sciences forensic genetics Y-STRS rapidly mutating Y-STRs sequence polymorphism isometric sequence variants massively parallel sequencing 
Recent Advances on Chiral Mobile Phase Additives: A Critical Review被引量：1
《Journal of Analysis and Testing》2022年第2期129-162,共34页Yuan Li Xiao-Ning Jin Yue Cheng Xiao-Fei Ma Yong Wang 
financially funded by the National Key R&D Program of China(2019YFC1905500);the National Natural Science Foundation of China(21922409,21976131);Tianjin Research Program of Application Foundation and Advanced Technology(18JCZDJC37500)
Chirality is one of the fundamental attributes of nature, which exists in different or even completely opposite metabolic,toxicological and pharmacological properties in organisms. Consequently, obtaining enantiomeric...
关键词：Chiral mobile phase additives High-performance liquid chromatography(HPLC) Capillary electrophoresis(CE) Countercurrent chromatography(CCC) Nano-liquid chromatography(Nano-LC) 
Determination of multiple drugs of abuse in human urine using dispersive liquid–liquid microextraction and capillary electrophoresis with PDA detection
《Forensic Sciences Research》2022年第2期265-271,共7页Liang Meng Shuhai Ye Yilin Wu Linda You 
The work was supported by the Programme of Outstanding Talents in the New Century in Universities of Fujian,China;Young Scientific Natural Science Foundation of Universities in Fujian.
A new method was developed for pre-concentration and determination of multiple drugs of abuse in human urine using dispersive liquid–liquid microextraction(DLLME)and capillary electrophoresis(CE)with photodiode array...
关键词：Forensic sciences forensic toxicology dispersive liquid-liquid microextraction capillary electrophoresis drugs of abuse urine sample 
Capillary electrophoresis methods for impurity profiling of drugs:A review of the past decade被引量：2
《Journal of Pharmaceutical Analysis》2022年第1期15-28,共14页Mansi Shah Nrupesh Patel Nagja Tripathi Vivek K.Vyas 
The authors would like to thank Institute of Pharmacy,Nirma University,Ahmedabad,India for providing the necessary facilities。
Capillary electrophoresis(CE)is widely used for the impurity profiling of drugs that contain stereochemical centers in their structures,analysis of biomolecules,and characterization of biopharmaceuticals.Currently,CE ...
关键词：Capillary electrophoresis IMPURITIES Impurity profiling DRUGS 
Pressure controllable aptamers picking strategy by targets competition
《Chinese Chemical Letters》2021年第1期218-220,共3页Ge Yang Chao Zhu Liping Zhao Linsen Li Yuanyu Huang Yukui Zhang Feng Qu 
the National Natural Science Foundation of China(Nos.21675012,21874010 and 21827810);the Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology。
Selection of aptamers with high affinity and good specificity requires multiple rounds of alternating steps of separation and PCR amplification.Herein,we proposed a novel high-efficiency aptamers picking strategy:One-...
关键词：Capillary electrophoresis Aptamer selection Screening pressure controllable Targets-synchronous competition One-round selection 
Challenges in Analysis of Hydrophilic Metabolites Using Chromatography Coupled with Mass Spectrometry被引量：2
《Journal of Analysis and Testing》2020年第3期140-162,共23页Qingyu Hu Huiru Tang Yulan Wang 
This work was supported by grant from the National Key R&D Program of China(2017YFC0906800).
Hydrophilic metabolites play important roles in cellular energy metabolism,signal transduction,immunity.However,there are challenges in both identification and quantification of the hydrophilic metabolites due to thei...
关键词：Hydrophilic metabolites Hydrophilic interaction chromatography Ion-pairing reversed-phase liquid chromatography Ion chromatography Capillary electrophoresis DERIVATIZATION 
Twenty-seven continental ancestry-informative SNP analysis of bone remains to resolve a forensic case被引量：2
《Forensic Sciences Research》2019年第4期364-366,共3页Qifan Sun Li Jiang Guangfeng Zhang Jing Liu Lei Zhao Wenting Zhao Caixia Li 
supported by the Basic Research Project[grant number 2016JB039];the Science and Technology Innovation Base Program of Beijing[grant number Z141106004414084];Key Projects in the National Science&Technology Pillar Program in the 12th-year Plan Period[grant number 2012BAK02B01].
We employed our previously developed 27-plex ancestry-informative single nucleotide polymorphism(SNP)panel to infer the ancestral components of bone remains of a possible foreign pilot found in south-western China.For...
关键词：Forensic science skeletal remains ancestry inference SNPs multiplex assay capillary electrophoresis 
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