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CHAIN: 作品数：1276被引量：1740H指数：17; 导出分析报告; 相关领域：理学医药卫生更多>>; 相关作者：韩俊林李晓松丛方媛王彩玲师义民更多>>; 相关机构：四川大学中国科学技术大学武汉大学浙江大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划国家社会科学基金更多>>

The regulatory role of lncRNA in tumor drug resistance:refracting light through a narrow aperture: 《Oncology Research》2025年第4期837-849,共13页HENG ZHANG XIAO YANG YUJIN GUO HAIBO ZHAO PEI JIANG QING-QING YU; supported by the grant of the Medicine and Health Care Science and Technology Development Plan Projects Foundation of Shandong Province(No.202301060260).; As living conditions improve and diagnostic capabilities advance,the incidence of tumors has increased,with cancer becoming a leading cause of death worldwide.Surgery,chemotherapy,and radiotherapy are the most common ...; 关键词：Long chain non coding RNA(LncRNA) Gene regulatory mechanisms Tumor resistance CHEMOTHERAPY

Improve GMRACCF Qualifications via Collaborative Filtering in Vehicle Sales Chain: 《Tsinghua Science and Technology》2025年第1期247-261,共15页Beiteng Yang Haibin Zhu Dongning Liu; supported by the National Key Research and Development Program of China(No.2022YFB3304400);the National Natural Science Foundation of China(No.62072120);the Natural Sciences and Engineering Research Council(NSERC)of Canada(No.RGPIN2018-04818);the Guangdong Provincial Key Laboratory of Cyber-Physical System(No.2020B1212060069).; The Vehicle Allocation Problem(VAP)in the vehicle sales chain has three bottlenecks in practice.The first is to collect relevant cooperation or conflict information,the second is to accurately quantify and analyze oth...; 关键词：Vehicle Allocation Problem(VAP) Group Multi-Role Assignment with Cooperation and Conflict Factors(GMRACCF) KD45 logic algorithm collaborative filtering semantic modification Cooperation and Conflict Factors(CCFs) Cooperation Scale(CS)

Size-selective hybridization chain reaction for accurate signal amplification in living cancer cells: 《Science China Chemistry》2024年第12期4259-4266,共8页Ting Chen Xiaojiao Wang Rongrong Gao Meihe Yuan Mei Chen Xiao-Bing Zhang Guoliang Ke; supported by the National Natural Science Foundation of China(22122403,22274042,22234003);the Natural Science Foundation of Hunan Province(2021JJ10012)。; Accurate signal amplification in living cells is highly important in biomedical research and medical diagnostics.Benefiting from its enzyme-free,efficient isothermal signal amplification ability,hybridization chain re...; 关键词：hybridization chain reaction microRNA DNA nanotechnology

How Does Social Media Usage Intensity Influence Adolescents’Social Anxiety:The Chain Mediating Role of Imaginary Audience and Appearance Self-Esteem: 《International Journal of Mental Health Promotion》2024年第12期977-985,共9页Yunyu Shi Fanchang Kong Min Zhu; supported by the Ministry of Education of Humanities and Social Science project(2022YJA190006);Research Program Funds of the Collaborative Innovation Center of Assessment toward Basic Education Quality at Beijing Normal University(2023-04-010-BZPKO1).; Background:To reduce adolescents’social anxiety,the study integrates external factors(social media usage)with internal factors(imaginary audience and appearance-based self-esteem)to internal mechanisms of adolescents...; 关键词：Social media usage intensity social anxiety imaginary audience appearance self-esteem adolescents

Promoting Post-Traumatic Growth in Colorectal Cancer Patients:Exploring the Role of Social Support through a Chain Mediation Model: 《Psycho-Oncologie》2024年第3期233-240,共8页Xia Sun Qin Li Yang Li Wenjun Yan Shuai Gong Wenjing Yan; Colorectal cancer(CRC)poses signiﬁcant physical and psychological challenges that necessitate an exploration of factors inﬂuencing post-traumatic growth(PTG)for patient well-being.This study aims to investigate the ef...; 关键词：Social support positive psychological capital perceived stress mediating effect post-traumatic growth

Text Reasoning Chain Extraction for Multi-Hop Question Answering: 《Tsinghua Science and Technology》2024年第4期959-970,共12页Pengming Wang Zijiang Zhu Qing Chen Weihuang Dai; With the advent of the information age, it will be more troublesome to search for a lot of relevant knowledge to find the information you need. Text reasoning is a very basic and important part of multi-hop question a...; 关键词：intelligent computing multi-hop quiz text reasoning document retrieval text complex network

M1磁珠富集联合重组酶介导的聚合酶链式反应技术检测肺炎克雷伯菌: 《中国科技期刊数据库医药》2024年第8期147-152,共6页张盼盼帖彦清; 一直以来,人类健康都在承受着病原微生不同程度的威胁,其中肺炎克雷伯菌是常见的条件致病菌之一,当机体免疫力低下时,容易发生炎性病变,从而引起肺炎、尿路感染和败血症等院内感染。综合分析肺炎克雷伯菌的致病特征,认为快速、准确地从...; 关键词：肺炎克雷伯菌 M1磁珠重组酶介导聚合酶链式反应 (polymerase CHAIN reaction PCR)

Efficacy and safety of modified medium-chain triglyceride ketogenic diet in patients with drug-resistant epilepsy: 《Acta Epileptologica》2024年第1期44-52,共9页Hua Li Yao Wang Jing Guo Peiqi Zhang Zheng Xu Kai Peng Xiaoli Dong Liming Zhao; supported by Guangzhou Science and Technology Planning Project(No.202102080427);China Association against Epilepsy research foundation(No.CJ-2022-018).; Background Medium-chain triglyceride ketogenic diet(MCTKD)is previously less commonly used in China.This study was aimed to assess the efficacy and safety of the modified MCTKD in the treatment of drug-resistant epile...; 关键词：Medium-chain triglyceride ketogenic diet Ketogenic diet Drug-resistant epilepsy EFFICACY Safety

The effect of lengths of branched-chain fatty alcohols on the efficacy and safety of docetaxel-prodrug nanoassemblies: 《Acta Pharmaceutica Sinica B》2024年第3期1400-1411,共12页Shuo Wang Tian Liu Yuetong Huang Chaoying Du Danping Wang Xiyan Wang Qingzhi Lv Zhonggui He Yinglei Zhai Bingjun Sun Jin Sun; financially supported by National Key R&D Program of China(No.2022YFE0111600);National Natural Science Foundation of China(No.82272151 and 82204318);Doctoral Scientific Research Staring Foundation of Liaoning Province(No.2021-BS-130,China);General Program of Department of Education of Liaoning Province(No.LJKZ0953,China);Shenyang Young and Middle-aged Science and Technology Innovation Talents Support Program(RC220389,China)。; The self-assembly prodrugs are usually consisted of drug modules,activation modules,and assembly modules.Keeping the balance between efficacy and safety by selecting suitable modules remains a challenge for developing...; 关键词：PRODRUGS NANOASSEMBLIES Self-assembly Branched-chain fatty alcohols Disulfide bond DOCETAXEL Efficacy Safety

Case Report: Carnitine Palmitoyl Transferase II (CPT II) Deficiency: 《Open Journal of Internal Medicine》2024年第1期93-101,共9页Kathy Po Marius Chivu Edwin Rosas Balpreet Kaur; Carnitine Palmitoyl Transferase II (CPTII) is a very important enzyme that helps with the oxidation of long-chain fatty acid to produce energy. Deficiency in CPTII will lead to energy deficiency in the case of fasting...; 关键词：Carnitine Palmitoyl Transferase II (CPTII) Mitochondria Long Chain Fatty Acid Medium Chain Fatty Acid CARNITINE Carnitine Palmitoyl Transferase I (CPTI) Acyl-Carnitine BETA-OXIDATION RHABDOMYOLYSIS Myoglobinuria Renal Failure Hypoketotic Hypoglycemia

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