CHOLINE

作品数：133被引量：439H指数：11
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相关领域：医药卫生更多>>
相关作者：李永红黄宗文张鸿彦陈翼洪愉更多>>
相关机构：复旦大学成都军区昆明总医院四川大学华西医院山东大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金江苏省自然科学基金更多>>
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Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
《Acta Pharmacologica Sinica》2024年第9期1912-1925,共14页Mo-ting Liu Yao Zhang Cai-gui Xiang Tao Yang Xiao-han Wang Qiu-kai Lu Hui-min Lu Chen Fan Chun-lan Feng Xiao-qian Yang Duo-wu Zou Heng Li Wei Tang 
National Natural Science Foundation of China(No.82173822).
Ulcerative colitis(UC)is associated with changed dietary habits and mainly linked with the gut microbiota dysbiosis,necroptosis of epithelial cells,and mucosal ulcerations.Liver dysfunction and abnormal level of liver...
关键词：ulcerative colitis dyslipidemia methionine-choline deficient diet MACROPHAGES gut microbes fecal microbiota transplantation 
Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation
《Hepatobiliary Surgery and Nutrition》2024年第3期393-411,I0001,I0002,共21页Chen Wang Zhao-Yan Liu Wen-Ge Huang Zhi-Jun Yang Qiu-Ye Lan Ai-Ping Fang Meng-Jun Hou Xiao-Lin Luo Yao-Jun Zhang Si Chen Hui-Lian Zhu 
Basic and Applied Basic Research Foundation of Guangdong Province,China(grant No.2020A1515110682);Guangdong Provincial Science and Technology Project(grant No.2017A040406008);National Natural Science Foundation of China(grant Nos.81973016,82103825);Postdoctoral Science Foundation of China(grant No.2020M683135).
Background:Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-associated death.Emerging evidence suggests that autophagy plays a critical role in HCC tumorigenesis,metastasis,and prognosis.Choline is ...
关键词：Hepatocellular carcinoma(HCC) AUTOPHAGY CHOLINE solute carrier family 5 member 7(SLC5A7) 
Bao-Gan-Xiao-Zhi-Wan Treatment Attenuates Methionine-choline-deficient Diet-induced Metabolic Dysfunction-associated Steatohepatitis in Rats by Modulating the NF-κB Signal Pathway and Autophagy
《Journal of Clinical and Translational Hepatology》2024年第6期607-611,共5页Liming Zhou Xiaobin Zeng Xiaofang Wei Wanying Shen Jie Yao Weigang Wu Lanlan Ge Boping Zhou 
supported by the Basic and Applied Basic Research Foundation of Guangdong Province(2021A1515220185).
Non-alcoholic fatty liver disease(NAFLD)is a condition involving the accumulation of liver fat in excess of 5–10%of its weight after excluding excessive alcohol intake and any other causes of liver disease or steatos...
关键词：NAFLD liver INTAKE 
MFSD7c functions as a transporter of choline at the blood–brain barrier
《Cell Research》2024年第3期245-257,共13页Xuan Thi Anh Nguyen Thanh Nha Uyen Le Toan Q.Nguyen Hoa Thi Thuy Ha Anna Artati Nancy C.P.Leong Dat T.Nguyen Pei Yen Lim Adelia Vicanatalita Susanto Qianhui Huang Ling Fam Lo Ngah Leong Isabelle Bonne Angela Lee Jorge L.Granadillo Catherine Gooch Dejie Yu Hua Huang Tuck Wah Soong Matthew Wook Chang Markus R.Wenk Jerzy Adamski Amaury Cazenave-Gassiot Long N.Nguyen 
supported in part by Singapore Ministry of Health's National Research Council NMRC/OFIRG/0066/20,Singapore Ministry of Education grants (T2EP30221-0012,T2EP30123-0014,and NUHSRO/2022/067/T1 (to L.N.N.));the Synthetic Biology Translational Research Programme of the Yong Loo Lin School of Medicine of the National University of Singapore (NUHSRO/2020/077/MSC/02/SB to M.W.C.).
Mutations in the orphan transporter MFSD7c(also known as Flvcr2),are linked to Fowler syndrome.Here,we used Mfsd7c knockout(Mfsd7c^(-/-))mice and cell-based assays to reveal that MFSD7c is a choline transporter at the...
关键词：MFS BARRIER sized 
Maternal dietary deficiencies in folic acid or choline worsen stroke outcomes in adult male and female mouse offspring
《Neural Regeneration Research》2023年第11期2443-2448,共6页McCoy Clementson Lauren Hurley Sarah Coonrod Calli Bennett Purvaja Marella Agnes S.Pascual Kasey Pull Brandi Wasek Teodoro Bottiglieri Olga Malysheva Marie A.Caudill Nafisa M.Jadavji 
American Heart Association,No.20AIREA35050015 (to NMJ)。
Maternal one-carbon metabolism plays an important role in early life programming.There is a well-established connection between the fetal environment and the health status of the offspring.Howeve r,there is a knowledg...
关键词：APOPTOSIS choline metabolism folic acid ischemic stroke maternal diet motor function one-carbon metabolism stroke outcome 
COVID-19 vaccine related hypermetabolic lymph nodes on PET/CT:Implications of inflammatory findings in cancer imaging
《Oncology Research》2023年第2期117-124,共8页FERDINANDO CALABRIA ANTONIO BAGNATO GIULIANA GUADAGNINO MARIA TOTEDA ANTONIO LANZILLOTTA STEFANIA CARDEI ROSANNA TAVOLARO MARIO LEPORACE 
This study was approved by the Medical Ethics Committee of the“Mariano Santo”Hospital in Cosenza,Italy(CS391273).
We observed several patients presenting 2-[^(18)F]FDG uptake in the reactive axillary lymph node at PET/CT imaging,ipsilateral to the site of the COVID-19 vaccine injection.Analog finding was documented at[^(18)F]Chol...
关键词：[^(18)F]Choline 2-[^(18)F]FDG PET/CT COVID-19 VACCINE Italy Chemotherapy Inflammation SUVMAX 
A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice被引量：2
《Food Science and Human Wellness》2022年第6期1544-1554,共11页Peng Ma Rongrong Huang Yu Ou 
funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
Soy glycinin derived octapeptide(SGP8)is a peptide obtained from degradation of the soy glycinin,whose amino acid sequence is IAVPGEVA.To determine the effect of SGP8 on non-alcoholic fatty liver disease(NAFLD),steato...
关键词：Soy glycinin derived octapeptide(SGP8) Non-alcoholic fatty liver disease(NAFLD) HepG2 cells Methionine-choline deficient(MCD) SIRT1/AMPK pathway 
Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease被引量：13
《Acta Pharmaceutica Sinica B》2022年第9期3650-3666,共17页Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang 
supported by the grants from National Natural Science Foundation of China (82073915, 91849135, 81673485, 81773719, 81973312 and 81971306);National Key Research and Development Project (2018YFA0108301, China);Shanghai Science and Technology Commission Experimental Animal Grants (21XD1424900, 19140904700, 19140904900 and 21S11901200, China);Shanghai Shuguang Program (19SG32, China);Shanghai “Rising Stars of Medical Talent” Youth Development ProgramYouth Medical Talents-Clinical Pharmacist Program [SHWRS(2020)_087, China]
Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferr...
关键词：Ferroptosis GPX4 Alternative isoform Fatty liver OLIGOMERIZATION Methionine/choline-deficient diet High fat-fructose/sucrose diet Protein interaction 
Berberine treats atherosclerosis via a vitamine-like effect downregulating Choline-TMA-TMAO production pathway in gut microbiota被引量：37
《Signal Transduction and Targeted Therapy》2022年第8期3008-3020,共13页Shu-Rong Ma Qian Tong Yuan Lin Li-Bin Pan Jie Fu Ran Peng Xian-Feng Zhang Zhen-Xiong Zhao Yang Li Jin-Bo Yu Lin Cong Pei Han Zheng-Wei Zhang Hang Yu Yan Wang Jian-Dong Jiang 
funded by the CAMS Innovation Fund for Medical Sciences(CIFMS)(Nos.2021-1-I2M-007,2016-I2M-3-011);the National Natural Science Foundation of China(Nos.82173888,81973290);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study(Z141102004414062)。
Trimethylamine-N-oxide(TMAO)derived from the gut microbiota is an atherogenic metabolite.This study investigates whether or not berberine(BBR)could reduce TMAO production in the gut microbiota and treat atherosclerosi...
关键词：VITAMIN INTESTINE TMAO 
Brief electrical nerve stimulation enhances intrinsic repair capacity of the focally demyelinated central nervous system被引量：4
《Neural Regeneration Research》2022年第5期1042-1050,共9页Lydia Ayanwuyi Nataliya Tokarska Nikki A.McLean Jayne M.Johnston Valerie M.K.Verge 
supported by Multiple Sclerosis Society of Canada(MSSOC),No.2362(to VMKV);Canadian Institutes of Health Research(CIHR),No.14238(to VMKV);were supported by University of Saskatchewan College of Medicine Research Awards(Co MGRADs)。
Our lab has shown that brief electrical nerve stimulation(ES)has a dramatic impact on remyelination of lysophosphatidyl choline(LPC)-induced focally demyelinated rat peripheral nerves,while also inducing an axon-prote...
关键词：axon protection DEMYELINATION immune response lysophosphatidyl choline macrophage microglia multiple sclerosis MYELIN nervous system repair neural activity polarization 
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