CHOLINE

作品数：133被引量：439H指数：11
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相关领域：医药卫生更多>>
相关作者：李永红黄宗文张鸿彦陈翼洪愉更多>>
相关机构：复旦大学成都军区昆明总医院四川大学华西医院山东大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金江苏省自然科学基金更多>>
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Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
《Acta Pharmacologica Sinica》2024年第9期1912-1925,共14页Mo-ting Liu Yao Zhang Cai-gui Xiang Tao Yang Xiao-han Wang Qiu-kai Lu Hui-min Lu Chen Fan Chun-lan Feng Xiao-qian Yang Duo-wu Zou Heng Li Wei Tang 
National Natural Science Foundation of China(No.82173822).
Ulcerative colitis(UC)is associated with changed dietary habits and mainly linked with the gut microbiota dysbiosis,necroptosis of epithelial cells,and mucosal ulcerations.Liver dysfunction and abnormal level of liver...
关键词：ulcerative colitis dyslipidemia methionine-choline deficient diet MACROPHAGES gut microbes fecal microbiota transplantation 
A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice被引量：2
《Food Science and Human Wellness》2022年第6期1544-1554,共11页Peng Ma Rongrong Huang Yu Ou 
funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
Soy glycinin derived octapeptide(SGP8)is a peptide obtained from degradation of the soy glycinin,whose amino acid sequence is IAVPGEVA.To determine the effect of SGP8 on non-alcoholic fatty liver disease(NAFLD),steato...
关键词：Soy glycinin derived octapeptide(SGP8) Non-alcoholic fatty liver disease(NAFLD) HepG2 cells Methionine-choline deficient(MCD) SIRT1/AMPK pathway 
Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease被引量：13
《Acta Pharmaceutica Sinica B》2022年第9期3650-3666,共17页Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang 
supported by the grants from National Natural Science Foundation of China (82073915, 91849135, 81673485, 81773719, 81973312 and 81971306);National Key Research and Development Project (2018YFA0108301, China);Shanghai Science and Technology Commission Experimental Animal Grants (21XD1424900, 19140904700, 19140904900 and 21S11901200, China);Shanghai Shuguang Program (19SG32, China);Shanghai “Rising Stars of Medical Talent” Youth Development ProgramYouth Medical Talents-Clinical Pharmacist Program [SHWRS(2020)_087, China]
Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferr...
关键词：Ferroptosis GPX4 Alternative isoform Fatty liver OLIGOMERIZATION Methionine/choline-deficient diet High fat-fructose/sucrose diet Protein interaction 
TLR4 Knockout Attenuates BDL-induced Liver Cholestatic Injury through Amino Acid and Choline Metabolic Pathways被引量：1
《Current Medical Science》2021年第3期572-580,共9页Shou-hua ZHANG Meng-jie YU Jin-long YAN Ju-hua XIAO Yu XIAO Jia-le YANG Jun LEI Xin YU Wei-long CHEN Yong CHAI 
the National Natural Science Foundation of China(Nos.81960101,81860483).
The exact mechanism by which knockout of Toll-like receptor 4(TLR4)attenuates the liver injury remains unclear.The present study aimed to examine the role of TLR4 in the pathogenesis of bile duct ligation(BDL)-induced...
关键词：Toll-like receptor 4 biliary obstruction metabolomics LIVER bile duct ligation 
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation被引量：5
《World Journal of Gastroenterology》2020年第34期5101-5117,共17页David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato 
National Institutes of Health Grant,No.R01CA172086;Plan Nacional of I+D,No.SAF2017-88041-R;Ministerio de Economía y Competitividad de España,No.SAF2017-87301-R;Asociación Española contra el Cáncer,No.AECC17/302;Ayudas Fundación BBVA a equipos de Investigación Científica 2018;Fondo Europeo de Desarrollo Regional,Ministerio de Economia y Competitividad de España,No.PGC2018-099857-BI00;Basque Government Grants,No.IT1264-19;Ministerio de Economia y Competitividad de España for the Severo Ochoa Excellence Accreditation,No.SEV-2016-0644.The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.
BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatit...
关键词：Nonalcoholic fatty liver disease STEATOHEPATITIS Methionine and choline deficient diet Tricarboxylic acid cycle Hemoglobin A1c Stearoyl-CoA desaturase 1 
Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood
《Genes & Diseases》2019年第1期68-77,共10页Juan Du Xuemei Cao Junlin Diao Qijuan Zhang Chuan Peng Jibin Li Xiaoqiu Xiao 
The present work was supported by the National Natural Science Foundation of China(grant nos.81270947 and 81570763,to XX);the National Program on Key Basic Research Project of China(973 Program;grant no.2012CB517505,to XX);the Fundamental Science and Advanced Technology Research of Chongqing(Major Project,grant no.CSTC2015jcyjB0146).
Overfeeding in early life is associated with obesity and insulin resistance in adulthood.In the present study,a well-characterized mouse model was used to investigate whether neonatal overfeeding increases susceptibil...
关键词：Inflammation Insulin resistance Neonatal overfeeding Non-alcoholic steatohepatitis Obesity 
Fatty Liver Disease and Gut Microbiota:A Comprehensive Update被引量：7
《Journal of Clinical and Translational Hepatology》2019年第1期56-60,共5页Lyna Campo Sara Eiseler Tehilla Apfel Nikolaos Pyrsopoulos 
Nonalcoholic fatty liver disease(NAFLD)is the accumulation of fat in the liver in the absence of secondary causes.NAFLD is a multifactorial disease that results from the interaction of genetic predisposition and metab...
关键词：Nonalcoholic fatty liver disease Gut microbiome DYSBIOSIS ENDOTOXINS Choline metabolism 
Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis被引量：16
《World Journal of Gastroenterology》2018年第23期2468-2481,共14页Jian-Zhong Ye Ya-Ting Li Wen-Rui Wu Ding Shi Dai-Qiong Fang Li-Ya Yang Xiao-Yuan Bian Jing-Jing Wu Qing Wang Xian-Wan Jiang Cong-Gao Peng Wan-Chun Ye Peng-Cheng Xia Lan-Juan Li 
the National Natural Science Foundation of China,No.81330011,No.81790631,and No.81790633;the Science Fund for Creative Research Groups of the National Natural Science Foundation of China,No.81721091;the National Basic Research Program of China(973 program),No.2013CB531401
AIM To investigate changes in gut microbiota and metabolism during nonalcoholic steatohepatitis(NASH) development in mice fed a methionine-choline-deficient(MCD) diet. METHODS Twenty-four male C57 BL/6 J mice were equ...
关键词：NONALCOHOLIC STEATOHEPATITIS Methioninecholine DEFICIENT DIET Gut microbiota METABOLOME NONALCOHOLIC fatty liver disease 
Γ-Aminobutyric acid promotes methionine-choline deficient diet-induced nonalcoholic steatohepatitis被引量：1
《The Journal of Biomedical Research》2017年第1期65-73,共9页Yoon Seok Roh Ara Cho Zixiong Zhou Hyuneui Jeong Jeong-Eun Park Youn-Soo Cha Suk-Heung Oh Chae-Woong Lim Bumseok Kim 
supported by the National Research Foundation of Korea Grant funded by the Korean Government(No.2008-0061604);supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF),whichis funded by the Ministry of Science,ICT & Future Planning 18(2014R1A1A1006622)
Nonalcoholic steatohepatitis（NASH） is one of the most common liver diseases and a major cause of liver fibrosis worldwide.r-Aminobutyric acid（GABA） is one of the most abundant inhibitory neurotransmitters in the c...
关键词：Γ-Aminobutyric acid nonalcoholic steatohepatitis methionine-choline-deficient diet mice GABA 
Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis被引量：1
《World Journal of Gastroenterology》2014年第47期17839-17850,共12页Yvette Simon Sonja M Kessler Katja Gemperlein Rainer M Bohle Rolf Müller Johannes Haybaeck Alexandra K Kiemer 
Supported by An EASL Sheila Sherlock fellowship;a Bank Austria visiting scientist program fellowship(to Kessler SM)
AIM: To characterize how insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IMP2-2 promotes steatohepatitis in the absence of dietary cholesterol.
关键词：Insulin-like growth factor 2 mRNA binding protein 2-2 Methionine/choline deficient Non-alcoholic fatty liver disease FILIPIN Iron 
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