CHROMOSOME

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Chromosome-level genome assembly of the kiang (Equus kiang) illuminates genomic basis for its high-altitude adaptation
《Integrative Zoology》2024年第6期1199-1210,共12页Chuang ZHOU Xiaofeng ZHENG Kexin PENG Kaize FENG Bisong YUE Yongjie WU 
supported by the Second Tibetan Plateau Scientific Expedition and Research Program(No.2019QZKK0501);the National Natural Science Foundation of China(No.32270454).
The kiang(Equus kiang)can only be observed in the Qinghai–Tibet Plateau(QTP).The kiang displayed excellent athletic performance in the high-altitude environment,which attracted wide interest in the investigation of t...
关键词：chromosome-level genome high-altitude adaptation kiang missense mutation positive selection structural variation 
The first chromosome-level genome assembly and transcriptome sequencing provide insights into cantharidin production of the blister beetles
《Integrative Zoology》2024年第5期929-940,共12页Chuang ZHOU Xiaofeng ZHENG Lei WANG Bisong YUE Chao DU Xu LIU 
supported by the National Natural Science Foundation of China(grant number:31960117);the Miaozi Project in Science and Technology Innovation Program of Sichuan Province(grant number:2022006).
Blister beetles(Coleoptera:Meloidae)produce a natural defensive toxin cantharidin(CTD),which has been used for various cancer treatments and other diseases.Currently,the lack of chromosome-level reference genomes in M...
关键词：blister beetle cantharidin biosynthesis chromosome-level genome cytochrome P450 differentially expressed gene Mylabris phalerata sexual dimorphism 
New genes driven by segmental duplications share a testis-specific expression pattern in the chromosome-level genome assembly of tree sparrow
《Integrative Zoology》2024年第5期1004-1008,共5页Shengnan WANG Yue SHEN Zhaocun LIN Yuquan MIAO Chengqi WANG Wenya ZHANG Yingmei ZHANG 
supported by the National Natural Science Foundation of China(No.31572216);the Foundation for Excellent Doctoral Student of Gansu Province(No.22JR5RA413).
The origination of new genes is a fundamental question in genome evolution,and gene duplication is one of the most important mechanisms for the formation of new genes(Ohno 1970;Long et al.2003;Kaessmann 2010;Ding et a...
关键词：al. SEGMENTAL pattern 
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins
《Acta Pharmaceutica Sinica B》2024年第8期3760-3773,共14页Qien Li Yiqun Dai Xin-Cheng Huang Lanlan Sun Kaixuan Wang Xiao Guo Dingqiao Xu Digao Wan Latai An Zixuan Wang Huanying Tang Qi Qi Huihui Zeng Minjian Qin Jia-Yu Xue Yucheng Zhao 
supported by the Western Light Project of the Chinese Academy of Sciences and the Young Qihuang Scholars Project of the National Administration of Traditional Chinese Medicine.This research was also funded by the open foundation of Shaanxi University of Chinese Medicine state key laboratory of R&D of Characteristic Qin Medicine Resources(SUCM-QM202202,China);the fund of Traditional Chinese Medicine Institute of Anhui Dabie Mountain(TCMADM-2023-18,China);“Double FirstClass”University Project of China Pharmaceutical University(CPU2022QZ27,China);supported by the key project at the central government level:the ability establishment of sustainable use for valuable Chinese medicine resources(2060302,China);the open research fund of Yunnan characteristic plant extraction laboratory(YKKF2023002,China)。
Coumarins,derived from the phenylpropanoid pathway,represent one of the primary metabolites found in angiosperms.The alignment of the tetrahydropyran(THP)and tetrahydrofuran(THF)rings with the lactone structure result...
关键词：Notopterygium incisum Parallel evolution BIOSYNTHESIS Pyranocoumarins FURANOCOUMARINS 
Hepatoprotective effects of Xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism被引量：3
《World Journal of Hepatology》2024年第7期1051-1066,共16页Xiao-Li Mei Shu-Yi Wu Si-Lan Wu Xiao-Lin Luo Si-Xing Huang Rui Liu Zhe Qiang 
Supported by Chongqing Fundamental Research Funds,No.jbky20210001;Key Programs of Technological Innovation and Application Development of Chongqing,China,No.cstc2021jscx-dxwtBX0016;Natural Science Foundation of Chongqing,No.cstc2021jcyjmsxmX0793;Science and Technology Project in Social Livelihood of Bishan District,Chongqing,China,No.BSKJ0078 and No.BSKJ0075;Performance Incentive-oriented Project of Chongqing,No.jxjl20220007。
BACKGROUND The modified Xiaoyao San(MXS)formula is an adjuvant drug recommended by the National Health Commission of China for the treatment of liver cancer,which has the effect of preventing postoperative recurrence ...
关键词：Hepatic steatosis INFLAMMATION Sex hormone metabolism Male hormone Phosphatase and tensin homolog deleted on chromosome ten 
Effect of miR-130a targeting phosphase and tensin homology deleted on chromosome ten/ phosphoinositol 3 kinase/protein kinase B axis on apoptosis of renal tissue cells in rats with diabetic kidney disease
《China Medical Abstracts(Internal Medicine)》2024年第2期94-94,共1页许春梅 
Objective To investigate the effect of miR-130a targeting phosphase and tensin homology deleted on chromosome ten(PTEN)/phosphoinositide 3 kinase(PI3K)/protein kinase B(AKT)pathway on renal tissue cell apoptosis in di...
关键词：miR RATS KIDNEY 
Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells
《Asian Journal of Andrology》2024年第2期165-174,共10页Hai-Wei Feng Yu Zhao Yan-Ling Gao Dong-Teng Liu Li-Jun Huo 
supported by the Shenzhen Science and Technology Program,China(No.KQTD20190929172749226).
Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various proteins.The mitochondrial protease complex(ClpXP),which consists of caseinolyti...
关键词：ClpX homologous chromosome MEIOSIS MITOCHONDRIAL recombination SYNAPSIS 
Single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in Saudi Arabia
《Asian Journal of Urology》2024年第1期26-32,共7页Awad Elsid Osman Sahar Alharbi Atif Ali Ahmed Asim Ali Elbagir 
supported by King Fahad Medical City,Riyadh,Saudi Arabia(IRF No:017-059).
Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that...
关键词：Prostatecancer SAUDI Singlenucleotide polymorphism ALLELE 
Chromosome-level genome assembly of Oncomelania hupensis: the intermediate snail host of Schistosoma japonicum被引量：1
《Infectious Diseases of Poverty》2024年第1期16-26,共11页Qin Liu Lei Duan Yun-Hai Guo Li-Min Yang Yi Zhang Shi-Zhu Li Shan Lv Wei Hu Nan-Sheng Chen Xiao-Nong Zhou 
supported by National Key Research and Development Program of China(No.2021YFC2300800,2021YFC2300803).
Background Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China, the Philippines and Indonesia.Oncomelania hupensis (Gastropoda: Pomatiops...
关键词：SCHISTOSOMIASIS Schistosoma japonicum Oncomelania hupensis Chromosome-level genome 
Relationship Between Gene-Phenotype and Clinical Manifestations of Chromosomal Copy Number Variations Indicated by Non-Invasive Prenatal Testing
《Journal of Clinical and Nursing Research》2024年第1期88-95,共8页Zixin Pi Xiaoyan Duan Jing Peng Yanhui Liu 
Dongguan City Social Development Project(Project number:20161081101023)。
Objective:To analyze the clinical value of non-invasive prenatal testing(NIPT)in detecting chromosomal copy number variations(CNVs)and to explore the relationship between gene expression and clinical manifestations of...
关键词：Non-invasive prenatal testing Chromosomal copy number variation Chromosomes 1 and 3 Chromosome 4 Chromosome 7 Chromosome 15 Prenatal diagnosis 
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