National Key Research and Development Program,Grant/Award Number:2019YFA0903800,2021YFA0805701,2021YFA0805905 and 2022YFA1103603;CAS Project for Young Scientists in Basic Research,Grant/Award Number:YSBR-012;STI 2030-Major Project,Grant/Award Number:2023ZD0407503;National Natural Science Foundation of China,Grant/Award Number:32071456 and 82241224;Strategic Priority Research Program of the Chinese Academy of Sciences,Grant/Award Number:XDA16030000。
Background:Pig organ xenotransplantation is a potential solution for the severe organ shortage in clinic,while immunogenic genes need to be eliminated to improve the immune compatibility between humans and pigs.Curren...
supported by the“Excellence Initiative—Research University”program at the Nicolaus Copernicus University;K.P.is supported by the subsidy from the Polish Ministry of Science and Higher Education for the research on the SARS-CoV-2 and a grant from the National Science Center UMO-2017/27/B/NZ6/02488;C.S.v.B.is supported by grant GM103554 from the National Institutes of Health.
In a recent paper in Science,Bruchez et al.1 provide new insights how host cells can fight virus infection.They show that an MHC class II transactivator(CIITA)—which normally operates as part of the interferon(IFN)-s...