supported by the National Key Research and Development Program of China(No.2017YFC1309102);National Natural Science Foundation of China(No.81771912,No.82001986,No.82071892);National Science Fund for Distinguished Young Scholars(No.81925023);High-level Hospital Construction Project(No.DFJH201805 and No.DFJH201914)。
Objective: The Immunoscore method has proved fruitful for predicting prognosis in patients with colon cancer.However, there is still room for improvement in this scoring method to achieve further advances in its clini...
supported by National Key Research and Development Program of China(No.2017YFC1308800);Industry-University-Research Innovation Fund in Ministry of Education of the People’s Republic of China(No.2018A01013)。
Objective:The goal of this study was to get preliminary insight on the intra-tumor heterogeneity in colitisassociated cancer(CAC)and to reveal a potential evolutionary trajectory from ulcerative colitis(UC)to CAC at t...
supported by Zhejiang Basic Public Welfare Research Project(No.LGF18H160040)。
Objective:Ankyrin repeat domain-containing protein 6(ANKRD6)is an ankyrin repeat-containing protein which is structurally related to vertebrate inversin and Drosophila Diego.However,the correlations between ANKRD6 and...
Objective: The aim of the present study was to investigate the effects of 5-fluorouracil(5-Fu) and oxaliplatin on the function and activation pathways of mouse dendritic cells(DCs), and to clarify whether 5-Fu/ox...
financial support of this project received from Metromedia Bio-Science, LLC
Objective: The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merit...
Erythroprotein-producing human hepatocellular carcinoma receptors (Eph receptors) compose a subfamily of transmembrane protein-tyrosine kinases receptors that takes part in numerous physiological and pathological pr...
supported by grants from the National Natural Science Foundation of China (Grant No. 81472620);Shanghai Science and Technology Planning Fund (No. 13140902100);Shanghai Combination Study Project for Major Diseases (No. 2014ZYJB0101);Shanghai Health and Family Planning Commission (No. JGY1404)
Objective: The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy(NAC) using oxaliplatin plus capecitabine(Cap OX) for patients with operable loc...
Objective: This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer.Methods: Patients with clinical...
Objective: Prognosis of colorectal cancer strongly depends on stage at diagnosis, which can be cured in most cases at an early stage. The results were supported by different screening programmes. Few data concerning ...
Among the colorectal cancers, the incidence of colon cancer has obviously increased. As a result, the actual incidence of colon cancer has exceeded that of rectal cancer, which dramatically changed the longexisting ep...