support from the National Natural Science Foundation of China(Nos.81861138045,22177121);the CAMS Innovation Fund forMedical Sciences(2019-12M-5-080);the Biological Resources Program,CAS(KFJ-BRP-008-001)of People's Republicof China isgratefully acknowledged;support of Science and Technology Commission of Shanghai Municipality(20ZR1467800).
A total synthesis of 17-membered macrocyclolipopeptide dysoxylactam A,a potent agent reversing P-glycoprotein(P-gp)-mediated multidrug resistance(MDR)in cancer cells,was developed from the starting material(S)-2-methy...
The authors thank the National Natural Science Foundation of China(21462038);Key Laboratory of Eco-Environment-Related Polymer Materials of the Ministry of Education of China for their financial support for this work.
A one-pot three-component method for the synthesis of 2-methyl-3-aminobenzofurans using calcium carbide as a concise solid alkyne source,and salicylaldehydes and secondary amines as starting materials is described.Thi...
National Natural Science Foundation of China(Nos.21125207,21572088 and 21871118).
Design and development of new tactics and strategies to improve synthetic efficiency is a hot topic and main concern in nowadays’chemical synthesis of bioactive natural products.Cascade reactions,which construct seve...
This research work was financially supported by the National Natural Science Foundation of China (No. 21462024) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry (2013).
The regioselective effects of tert-butyl or bromine as the position-protecting group of feruloytyamide on the oxidative coupling reactions for the synthesis of natural (±)-canabisin D were investigated in detail. T...
the National Natural Science Foundation of China(21125208&20921092);National Basic Research Program of China(2010CB833300).
A concise synthesis of 2-(2-hydroxyphenyl)acetonitriles has been developed through reaction of trimethylsilyl cyanide and the o-quinone methides in situ generated from 2-(1-tosylalkyl)phenols under basic conditions.In...
A six-step synthesis of (-)-clausenamide is described. Optically pure (R,E)-1,3-diphenylallylic alcohol was ac-etylated and then subjected to an Ireland-Claisen rearrangement, giving the γ,δ-unsaturated acid, wh...
A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19-membered cycloalkene intermediates designed for dive...
A concise synthesis of BILN 2061 was achieved through more efficient installation of P2 4-quinoline moiety via SN2 displacement of the β-OBs group located on the 4-hydroxyl proline intermediate, which was prepared fr...
Project supported by Chinese Academy of Sciences Hundreds of Talent Program,Science & Technology Commission of Shanghai Municipality Venus Program(No.02QB14058)and National Natural Science Foundation of China(No.20102008).
Aucubinine B (4), a monoterpene alkaloid obtained from the metabolites of aucubin in the presence of human intestinal bacteria, has been synthesized from 3-bromo-4-pyridinecarbox-aldehyde (5) in four steps with 39% ov...