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作品数:237被引量:399H指数:11
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相关领域:医药卫生更多>>
相关作者:储冰峰李怀青周继林汪一鸣刘洪臣更多>>
相关机构:第四军医大学安徽省岳西县人民医院广东怡家实业投资有限公司广州市欧亚床垫家具有限公司更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金安徽省自然科学基金更多>>
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Concise Total Synthesis of Dysoxylactam A and a Simplified Analog
《Chinese Journal of Chemistry》2022年第17期2027-2034,共8页Guan-Zhou Yang Lei Wang Yao-Yue Fan Zeng-Wei Lai Xue-Ni Yu Li-Guang Lou Kun Gao Jian-Min Yue 
support from the National Natural Science Foundation of China(Nos.81861138045,22177121);the CAMS Innovation Fund forMedical Sciences(2019-12M-5-080);the Biological Resources Program,CAS(KFJ-BRP-008-001)of People's Republicof China isgratefully acknowledged;support of Science and Technology Commission of Shanghai Municipality(20ZR1467800).
A total synthesis of 17-membered macrocyclolipopeptide dysoxylactam A,a potent agent reversing P-glycoprotein(P-gp)-mediated multidrug resistance(MDR)in cancer cells,was developed from the starting material(S)-2-methy...
关键词:Total synthesis Dysoxylactam A Macrocyclolipopeptide Reversing multidrug resistance Structure-activity relationship 
One-Pot Three-Component Synthesis of 2-Methyl-3-aminobenzofurans Using Calcium Carbide as a Concise Solid Alkyne Source被引量:1
《Chinese Journal of Chemistry》2021年第11期2990-2994,共5页Xiaolong Ma Zhiqiang Wang Zhenrong Liu Zheng Li 
The authors thank the National Natural Science Foundation of China(21462038);Key Laboratory of Eco-Environment-Related Polymer Materials of the Ministry of Education of China for their financial support for this work.
A one-pot three-component method for the synthesis of 2-methyl-3-aminobenzofurans using calcium carbide as a concise solid alkyne source,and salicylaldehydes and secondary amines as starting materials is described.Thi...
关键词:CYCLIZATION Multicomponent reactions Synthetic methods Calcium carbide Alkyne source BENZOFURAN 
Concise Total Syntheses of Bioactive Alkaloids Enabled by Development or Application of Cascade Reactions:A Personnel Adventure
《Chinese Journal of Chemistry》2021年第4期795-801,共7页Xingang Xie Xuegong She 
National Natural Science Foundation of China(Nos.21125207,21572088 and 21871118).
Design and development of new tactics and strategies to improve synthetic efficiency is a hot topic and main concern in nowadays’chemical synthesis of bioactive natural products.Cascade reactions,which construct seve...
关键词:Natural products ALKALOIDS Total synthesis Cascade reactions 
Regioselective Oxidation Approaches to Concise Synthesis of (±)-Canabisin D
《Chinese Journal of Chemistry》2015年第7期717-722,共6页Wenling Li Qian Liu Hao Liu PeUan Chen Xi Yang Yingying Liu 
This research work was financially supported by the National Natural Science Foundation of China (No. 21462024) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry (2013).
The regioselective effects of tert-butyl or bromine as the position-protecting group of feruloytyamide on the oxidative coupling reactions for the synthesis of natural (±)-canabisin D were investigated in detail. T...
关键词:oxidative coupling biomimetic synthesis regioselectivity liganamides canabisin D 
A Concise Synthesis of 2-(2-Hydroxyphenyl)acetonitriles via the o-Quinone Methides Generated from 2-(1-Tosylalkyl)phenols
《Chinese Journal of Chemistry》2014年第10期981-984,共4页Bo Wu Xiang Gao Mu-Wang Chen Yong-Gui Zhou 
the National Natural Science Foundation of China(21125208&20921092);National Basic Research Program of China(2010CB833300).
A concise synthesis of 2-(2-hydroxyphenyl)acetonitriles has been developed through reaction of trimethylsilyl cyanide and the o-quinone methides in situ generated from 2-(1-tosylalkyl)phenols under basic conditions.In...
关键词:2-(2-hydroxyphenyl)acetonitriles o-quinone methides 2-(1-tosylalkyl)phenols 
Novel Concise Synthesis of (-)-Clausenamide1被引量:1
《Chinese Journal of Chemistry》2013年第3期344-348,共5页Di Liu Xiaoming Yu Liang Huang 
A six-step synthesis of (-)-clausenamide is described. Optically pure (R,E)-1,3-diphenylallylic alcohol was ac-etylated and then subjected to an Ireland-Claisen rearrangement, giving the γ,δ-unsaturated acid, wh...
关键词:(-)-clausenamide diastereoselective synthesis Ireland-Claisen rearrangement diastereoselectivebromo|actonization bromo-c^-lactone aminolysis 
A Concise Total Synthesis of Amphidinin B
《Chinese Journal of Chemistry》2013年第1期105-110,共6页Dongdong Wu Jinlong Wu Wei-min Dai 
A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19-membered cycloalkene intermediates designed for dive...
关键词:amphidinin B CYCLOALKENE DIHYDROXYLATION oxidative cleavage total synthesis 
A Concise Synthesis of the HCV Protease Inhibitor BILN 2061 and Its P3 Modified Analogs
《Chinese Journal of Chemistry》2011年第7期1489-1502,共14页刘德军 董径超 尹云星 马汝建 施一峰 吴颢 陈曙辉 李革 
A concise synthesis of BILN 2061 was achieved through more efficient installation of P2 4-quinoline moiety via SN2 displacement of the β-OBs group located on the 4-hydroxyl proline intermediate, which was prepared fr...
关键词:hepatitis C virus (HCV) BILN 2061 SYNTHESIS 
Concise Syntheses of Arabinogalactans with β-(1→6)-Linked Galactopyranosyl Backbone and α-(1→3)-Linked Arabinofuranosyl Side Chains被引量:1
《Chinese Journal of Chemistry》2005年第1期7-10,共4页李爱肖 孔繁祚 
A Concise Synthesis of Monoterpene Pyridine Alkaloid Aucubinine B
《Chinese Journal of Chemistry》2003年第7期970-971,共2页杨晓霞 赵景瑞 贾学顺 杨力维 翟宏斌 
Project supported by Chinese Academy of Sciences Hundreds of Talent Program,Science & Technology Commission of Shanghai Municipality Venus Program(No.02QB14058)and National Natural Science Foundation of China(No.20102008).
Aucubinine B (4), a monoterpene alkaloid obtained from the metabolites of aucubin in the presence of human intestinal bacteria, has been synthesized from 3-bromo-4-pyridinecarbox-aldehyde (5) in four steps with 39% ov...
关键词:aucubinine B monoterpene alkaloid intramolecular Heck reaction 
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