CORTICAL_NEURONS

作品数：91被引量：300H指数：9
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相关作者：开丽薛春生王中峰华田苗化国鹏更多>>
相关机构：第三军医大学天津医科大学中国科学院上海生命科学研究院重庆医科大学更多>>
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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice
《Neural Regeneration Research》2025年第8期2348-2360,共13页Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel 
supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne,the Alzheimer Forschung Initiative e.V.(grant#22039,to HZ);open-access funding from the DFG/GRC issued to the University of Cologne;Alzheimer Forschung Initiative e.V.for Open Access Publishing(a publication grant#P2401,to MAAK)。
TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal...
关键词：human induced pluripotent stem cell MICROTUBULES P301L pR5 mice TAU TAUOPATHY tubulin code 
Transforming growth factor-beta 1 enhances discharge activity of cortical neurons
《Neural Regeneration Research》2025年第2期548-556,共9页Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao Sheng 
supported by the Natural Science Foundation of Guangdong Province,Nos.2019A1515010649(to WC),2022A1515012044(to JS);the China Postdoctoral Science Foundation,No.2018M633091(to JS).
Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may de...
关键词：central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents 
Whole-brain Mapping of Inputs and Outputs of Specific Orbitofrontal Cortical Neurons in Mice
《Neuroscience Bulletin》2024年第11期1681-1698,共18页Yijie Zhang Wen Zhang Lizhao Wang Dechen Liu Taorong Xie Ziwei Le Xiangning Li Hui Gong Xiao-Hong Xu Min Xu Haishan Yao 
supported by the STI2030-Major Projects(2021ZD0203700/2021ZD0203703);the National Natural Science Foundation of China(31771151 and 32171030 to H.Y.,32100829 to D.L.);the Lingang Lab(Grant LG202104-01-03);Shanghai Municipal Science and Technology Major Project(grant No.2018SHZDZX05);the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB32010200).
The orbitofrontal cortex(ORB),a region crucial for stimulus-reward association,decision-making,and flexible behaviors,extensively connects with other brain areas.However,brain-wide inputs to projection-defined ORB neu...
关键词：Orbitofrontal cortex Projection specific Rabies virus retrograde tracing Anterograde transsynaptic virus tracing Inhibitory neurons 
Alternating current stimulation promotes neurite outgrowth and plasticity in neurons through activation of the PI3K/AKT signaling pathway被引量：2
《Acta Biochimica et Biophysica Sinica》2023年第11期1718-1729,共12页Hao Zhong Cong Xing Mi Zhou Zeyu Jia Song Liu Shibo Zhu Bo Li Hongjiang Yang Hongpeng Ma Liyue Wang Rusen Zhu Zhigang Qu Guangzhi Ning 
supported by the grants from the Tianjin Key Medical Discipline (Specialty)Construct Project (No.TJYXZDXK-027A);the National Natural Science Foundation of China (Nos.82072439 and 82272470);the Tianjin Health Key Discipline Special Project (No.TJWJ2022XK011);the Basic Research Cooperation Project of Beijing-Tianjin-Hebei (No.20JCZXJC00080).
As a commonly used physical intervention,electrical stimulation(ES)has been demonstrated to be effective in the treatment of central nervous system disorders.Currently,researchers are studying the effects of electrica...
关键词：electrical stimulation cortical neurons neural regeneration neurite outgrowth and plasticity alternating current stimulation. 
Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial Glial Cells,Leading to Abnormal Differentiation and Migration of Cortical Neurons in Mice
《Neuroscience Bulletin》2023年第7期1131-1145,共15页Xue Li Shimin Zou Xiaomeng Tu Shishuai Hao Tian Jiang Jie-Guang Chen 
supported by the Wenzhou Municipal Science and Technology Bureau(Y20210901);the Natural Science Foundation of Zhejiang Province(LQ20H090001);the Scientific Research Fund of Wenling Science and Technology Bureau(2018C320001).
Heterozygous loss-of-function variants of FOXP4 are associated with neurodevelopmental disorders(NDDs)that exhibit delayed speech development,intellectual disability,and congenital abnormalities.The etiology of NDDs i...
关键词：NEUROGENESIS Radial migration Radial glial cell Ventricular zone N-CADHERIN 
Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons
《Genomics, Proteomics & Bioinformatics》2023年第3期551-572,共22页Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao Xiaobo Cen 
supported by the grants from the National Natural Science Foundation of China(Grant Nos.82071494,81871043,32000719,and 81272459);the 1.3.5 Project for Disciplines of Excellence of West China Hospital of Sichuan University(Grant No.ZYGD23011);the China Postdoctoral Science Foundation(Grant No.2021M702362);the PostDoctor Research Project,West China Hospital,Sichuan University(Grant No.2020HXBH010);the Sichuan Science and Technology Program(Grant No.23NSFSC2884);the Science,Technology and Innovation Commission of Shenzhen Municipality(Grant No.ZDSYS20190902093601675),China.
The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of chromatin.Morphine-induced aberrant gene networks of neurons have been extensively investigated;however,how morp...
关键词：MORPHINE Rhesus monkey Chromatin spatial architecture Topologically associated domain Loop 
Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis被引量：3
《Neural Regeneration Research》2022年第11期2504-2511,共8页An-Qi Zhang Lu Wang Yi-Xiu Wang Shan-Shan Hong Yu-Shan Zhong Ru-Yi Yu Xin-Lu Wu Bing-Bing Zhou Qi-Min Yu Hai-Feng Fu Shuang-Dong Chen Yun-Chang Mo Qin-Xue Dai Jun-Lu Wang 
funded by the National Natural Science Foundation of China,No.81803937(to YCM and QXD);Science and Technology Innovation Activity Plan for College Students of Zhejiang Province(Xinmiao Talent Plan),No.2020R413079(to AQZ);Wenzhou Science and Technology Plan Project,No.Y20210122(to QXD)。
Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia,but the mechanism underlying this relationship is unclea r.In this study,we found that miR-324-3p expression was d...
关键词：acute ischemic stroke adenosine A1 receptor apoptosis cerebral ischemia-reperfusion injury cortical neurons GATA2 middle cerebral artery occlusion miR-324-3p oxygen-glucose deprivation/reoxygenation PC12 cells 
Excitatory Crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons
《Neuroscience Bulletin》2022年第10期1139-1152,共14页Yuan-Jie Xiao Lidan Wang Yu-Zhang Liu Jiayu Chen Haoyu Zhang Yan Gao Hua He Zheng Zhao Zhiru Wang 
This work was supported by grants from the National Natural Science Foundation of China(31970957 and 31471078);the Shanghai Science and Technology Commission(19ZR1416600);funding from 2021-JCJQ-JJ-1089.
Crossmodal information processing in sensory cortices has been reported in sparsely distributed neurons under normal conditions and can undergo experience-or activity-induced plasticity.Given the potential role in bra...
关键词：Crossmodal input Crossmodal response Crossmodal plasticity Sensory cortex Crossmodal task Sensory loss GABAergic transmission 
Neuronal chemokine-like-factor 1(CKLF1)up-regulation promotes M1 polarization of microglia in rat brain after stroke被引量：8
《Acta Pharmacologica Sinica》2022年第5期1217-1230,共14页Xin Zhou Ya-ni Zhang Fang-fang Li Zhao Zhang Li-yuan Cui Hong-yuan He Xu Yan Wen-bin He Hong-shuo Sun Zhong-ping Feng Shi-feng Chu Nai-hong Chen 
This work was supported by the National Natural Science Foundation of China(81730096,82074044,81873026,81773924);the Natural Science Foundation of Beijing(7192135);the Drug Innovation Major Project(2018ZX09711001-002-007,2018ZX09711001-003-005,2018ZX09711001-009-013);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-1-004);the High-End Foreign Experts Introduction Program(G20200001485).
The phenotypic transformation of microglia in the ischemic penumbra determines the outcomes of ischemic stroke.Our previous study has shown that chemokine-like-factor 1(CKLF1)promotes M1-type polarization of microglia...
关键词：STROKE ischemic penumbra CKLF1 microglia polarization cortical neurons NF-κB inflammation 
Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey
《Neural Regeneration Research》2021年第12期2446-2452,共7页Xue-Yan Zhang Jun Li Cai-Juan Li Ying-Qi Lin Chun-Hui Huang Xiao Zheng Xi-Chen Song Zhu-Chi Tu Xiao-Jiang Li Sen Yan 
This work was supported by the National Natural Science Foundation of China,No.81922026(to SY);the National Key Research and Development Program of China Stem Cell and Translational Research,No.2017YFA0105104(to SY);Key Field Research and Development Program of Guangdong Province,No.2018B030337001(to XJL);Guangdong Key Laboratory of Non-human Primate Models of Brain Diseases,No.2020B121201006(to XJL);Guangzhou Key Research Program on Brain Science,No.202007030008(to SY);the Fundamental Research Funds for the Central Universities,No.21619104(to SY).
In vitro cultures of primary cortical neurons are widely used to investigate neuronal function.However,it has yet to be fully investigated whether there are significant differences in development and function between ...
关键词：Axion-MEA electrical activities human disease model Huntington’s disease HTT monkey neuron morphometric analysis mouse neuron neurodegenerative diseases primary culture 
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