DENDRITIC_CELLS

作品数:431被引量:1944H指数:21
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相关作者:王胜军林玮许化溪刘恭植季晓辉更多>>
相关机构:浙江大学医学院附属第二医院镇江医学院南京医科大学华中科技大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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  • 期刊=Cell Researchx
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LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells被引量:3
《Cell Research》2019年第5期406-419,共14页Leonard R.Pelgrom Thiago A.Patente Alexey Sergushichev Ekaterina Esaulova Frank Otto Arifa Ozir-Fazalalikhan Hendrik J.P.van der Zande Alwin J.van der Ham Stefan van der Stel Maxim N.Artyomov Bart Everts 
Liver Kinase B1(LKB1)plays a key role in cellular metabolism by controlling AMPK activation.However,its function in dendritic cell(DC)biology has not been addressed.Here,we find that LKB1 functions as a critical brake...
关键词:LKB1 EXPRESSED governs thymus-derived 
Innate immune signaling and regulation in cancer immunotherapy被引量:23
《Cell Research》2017年第1期96-108,共13页Leticia Corrales Vyara Matson Blake Flood Stefani Spranger Thomas F Gajewski 
A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be predictive for re- sponse to contemporary cancer immunotherapies. The generation of a spontaneous T cell response against tu...
关键词:innate immune signaling cancer immunotherapy dendritic cells STING 
Dendritic cells are stressed out in tumor被引量:1
《Cell Research》2015年第9期989-990,共2页Tomasz Maj Weiping Zou 
A recently paper published in Cell reports that dendritic cells (DCs) are dysfunctional in the tumor environment. Tumor impairs DC function through induction of endoplasmic reticulum stress response and subsequent d...
关键词:树突状细胞 肿瘤 突出 功能失调 代谢平衡 应激反应 内质网 
Metabolic reprogramming in macrophages and dendritic cells in innate immunity被引量:95
《Cell Research》2015年第7期771-784,共14页Beth Kelly Luke AJ O'Neill 
Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation (OXPHOS), similar to the Warburg...
关键词:MACROPHAGE dendritic cell metabolic reprogramming GLYCOLYSIS oxidative phosphorylation 
Identification of IFN-γ-producing innate B cells被引量:3
《Cell Research》2014年第2期161-176,共16页Yan Bao Xingguang Liu Chaofeng Han Sheng Xu Bin Xie Qian Zhang Yan Gu Jin Hou Li Qian Cheng Qian Huanxing Han Xuetao Cao 
Although B cells play important roles in the humoral immune response and the regulation of adaptive immunity, B cell subpopulations with unique phenotypes, particularly those with non-classical immune functions, shoul...
关键词:B cells IFN-Γ innate response dendritic cells CD40 
Immunosuppressive exosomes from TGF-pl gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells被引量:22
《Cell Research》2012年第3期607-610,共4页Zhijian Cai Wei Zhang Fei Yang Lei Yu Zhou Yu JihHung Pan Lie Wang Xuetao Cao Jianli Wang 
Acknowledgments We thank Ms Diya Yang for technical assistance. This work was supported by the National Key Basic Research Program of China (2007CB512403), the National Natural Science Foundation of China (30972725 and 31070795), the National Technology Key Projects of China (008ZX1002-008) and the Natural Science Foundation of Zhejiang Province (Z2090042).
Dear Editor, Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally believed to originate from the complicated interactions between genetic factors and commensal flora. Thi...
关键词:调节性T细胞 自身免疫性疾病 树突状细胞 免疫抑制 基因修饰 炎症 溃疡性结肠炎 介导 
Lipid-laden dendritic cells fail to function
《Cell Research》2010年第10期1089-1091,共3页Philip C Calder 
Dendritic cells (DCs) are professional antigen-acquiring, -processing and -presenting cells [1-4] . As such, DCs form the key link between the innate and acquired immune responses playing a role in host defence and...
关键词:树突状细胞 脂质 免疫耐受 免疫反应 宿主防御 生长缺陷 细胞表面 生理调节 
Enemy at the gates: dendritic cells and immunity to mucosal pathogens被引量:4
《Cell Research》2010年第8期872-885,共14页Adam C Soloff 
Dendritic cells (DC) are diverse and specialized hematopoietic cells serving as an essential bridge between innate and adaptive immunity. DC exist in all lymphoid and nonlymphoid organs and are amongst the first res...
关键词:cellular immunology respiratory gastrointestinal URINARY REPRODUCTIVE 
Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors被引量:7
《Cell Research》2006年第3期241-259,共19页Dajing Xia Terence Moyana Jim Xiang 
Recent developments in tumor immunology and biotechnology have made cancer gene therapy and immunotherapy feasible. The current efforts for cancer gene therapy mainly focus on using immunogenes, chemogenes and tumor s...
关键词:gene therapy ADENOVIRUS dendritic cells vaccine cytotoxic T lymphocytes antitumor immunity 
IRF family proteins and type I interferon induction in dendritic cells被引量:10
《Cell Research》2006年第2期134-140,共7页Prafullakumar Tailor Tomohiko Tamura Keiko Ozato 
Dendritic cells (DC), although a minor population in hematopoietic cells, produce type I interferons (IFN) and other cytokines and are essential for innate immunity. They are also potent antigen presenters and reg...
关键词:dendritic cells IRF-3 4 5 7 8 type  interferon induction activate transcription signaling pathway dependence 
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