Liver Kinase B1(LKB1)plays a key role in cellular metabolism by controlling AMPK activation.However,its function in dendritic cell(DC)biology has not been addressed.Here,we find that LKB1 functions as a critical brake...
A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be predictive for re- sponse to contemporary cancer immunotherapies. The generation of a spontaneous T cell response against tu...
A recently paper published in Cell reports that dendritic cells (DCs) are dysfunctional in the tumor environment. Tumor impairs DC function through induction of endoplasmic reticulum stress response and subsequent d...
Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation (OXPHOS), similar to the Warburg...
Although B cells play important roles in the humoral immune response and the regulation of adaptive immunity, B cell subpopulations with unique phenotypes, particularly those with non-classical immune functions, shoul...
Acknowledgments We thank Ms Diya Yang for technical assistance. This work was supported by the National Key Basic Research Program of China (2007CB512403), the National Natural Science Foundation of China (30972725 and 31070795), the National Technology Key Projects of China (008ZX1002-008) and the Natural Science Foundation of Zhejiang Province (Z2090042).
Dear Editor, Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally believed to originate from the complicated interactions between genetic factors and commensal flora. Thi...
Dendritic cells (DCs) are professional antigen-acquiring, -processing and -presenting cells [1-4] . As such, DCs form the key link between the innate and acquired immune responses playing a role in host defence and...
Dendritic cells (DC) are diverse and specialized hematopoietic cells serving as an essential bridge between innate and adaptive immunity. DC exist in all lymphoid and nonlymphoid organs and are amongst the first res...
Recent developments in tumor immunology and biotechnology have made cancer gene therapy and immunotherapy feasible. The current efforts for cancer gene therapy mainly focus on using immunogenes, chemogenes and tumor s...
Dendritic cells (DC), although a minor population in hematopoietic cells, produce type I interferons (IFN) and other cytokines and are essential for innate immunity. They are also potent antigen presenters and reg...