DNA_METHYLATION

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Epigenetic regulation of the inflammatory response in stroke
《Neural Regeneration Research》2025年第11期3045-3062,共18页Jingyi Liang Fei Yang Zixiao Li Qian Li 
supported by the National Natural Science Foundation of China,Nos.32070735(to QL),82371321(to QL),82171270(to ZL);Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1(to ZL);the Natural Science Foundation of Beijing,No.Z200016(to ZL);Beijing Talents Project,No.2018000021223ZK03(to ZL);Beijing Municipal Committee of Science and Technology,No.Z201100005620010(to ZL)。
Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either type.Immunologic mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytoki...
关键词：DNA methylation histone modification intracerebral hemorrhage ischemic stroke NEUROINFLAMMATION NEUROPROTECTION non-coding RNA RNA methylation subarachnoid hemorrhage treatment 
Maternal high-fat diet impairs offspring glucose metabolism and programs hepatic DNA methylation linked to NK cell-mediated cytotoxicity signaling pathway at weaning
《Food Science and Human Wellness》2025年第4期1576-1587,共12页Sheng Zheng Ling Zhang Shixuan Zhang Guanyu Hu Yikai Li Jia Zheng 
sponsored by National Natural Science Foundation of China(81800703);Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZC20231088);Beijing Nova Program(Z201100006820117 and 20220484181);Beijing Municipal Natural Science Foundation(7184252);the Fundamental Research Funds for the Central Universities;the Fundamental Research Funds for the Central Universities(BMU2021MX013);Peking University Clinical Scientist Training Program(BMU2023PYJH022);Peking University Medicine Seed Fund for Interdisciplinary Research;China Endocrine and Metabolism Young Scientific Talent Research Project(2022-N-02-01);China Diabetes Young Scientific Talent Research Project;Bethune-Merck Diabetes Research Fund of Bethune Charitable Foundation。
Maternal consumption of a high-fat diet has been linked to increased risks of obesity and impaired glucose metabolism in offspring.However,the precise epigenetic mechanisms governing these intergenerational effects,pa...
关键词：Maternal high-fat diet consumption Glucose metabolism DNA methylation Natural killer cell-mediated cytotoxicity WEANING 
The genomic and epigenomic landscape of iridocorneal endothelial syndrome
《Genes & Diseases》2025年第3期523-532,共10页Yaoming Liu Gen Li Jiaxuan Jiang Sujie Fan Lan Lu Ting Wang Guigang Li Wenzong Zhou Xuequn Liu Yingjie Li Hong Sun Liang Liang Yuhong Tang Yang Chen Jianjun Gu Fei Li Xiuli Fang Tao Sun Aiguo Lv Yayi Wang Peiyuan Wang Tao Wen Jiayu Deng Yuhong Liu Mingying Lai Jingni Yu Danyan Liu Hua Wang Meizhu Chen Li Li Xiaodan Huang Jingming Shi Xu Zhang Kang Zhang Lingyi Liang Xiulan Zhang 
supported by the National Key Research and Development Program of China(No.2022YFC2502800);the National Natural Science Foundation of China(No.82070955,32000537).
Iridocorneal endothelial (ICE) syndrome is a rare, irreversibly blinding eye diseasewith an unknown etiology. Understanding its genomic and epigenomic landscape could aid indeveloping etiology-based therapies. In this...
关键词：Copy number variance DNA methylation ETIOLOGY Iridocorneal endothelial syndrome Whole-genome sequencing 
MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B
《World Journal of Diabetes》2025年第4期189-204,共16页Ying Yang Yi Chen Jian-Ying Tang Jian Chen Gui-Qing Li Bing Feng Jiao Mu 
Supported by the Chongqing Basic Research and Frontier Exploration Project,No.cstc2018jcyjAX0834.
BACKGROUND At present,the incidence of diabetic nephropathy is increasing year by year,and there are many studies on the pathogenesis of diabetic nephropathy,but it is still not completely clear.The final pathological...
关键词：Diabetic kidney disease Mir-29a-3p DNA methylation Janus kinase/signal transducer and activator of transcription WNT/Β-CATENIN Renal fibrosis 
Dynamic DNA methylation modification in catechins and terpenoids biosynthesis during tea plant leaf development
《Horticultural Plant Journal》2025年第2期906-920,共15页Jiahao Chen Yang Hu Zhangsheng Zhu Peng Zheng Shaoqun Liu Binmei Sun 
supported by the Natural Science Foundation of Guangdong Province(Grant Nos.2022A1515111141 and 2023A1515010786)。
DNA methylation plays important roles in regulating gene expression during development.However,little is known about the influence of DNA methylation on secondary metabolism during leaf development in the tea plant(Ca...
关键词：Camellia sinensis DNA methylation leaf development CATECHINS TERPENOIDS Gene regulation 
Buccal DNA global methylation and cognitive performance in stunted children under five years of age
《Journal of Biomedical Research》2025年第2期146-154,共9页Ahmad Rusdan Handoyo Utomo Yusnita Yusnita Siti Maulidya Sari Octaviani Indrasari Ranakusuma Sunu Bagaskara Wening Sari Yulia Suciati Anggi Puspa Nur Hidayati Silviatun Nihayah Catur Anggono Putro Neni Nurainy 
Ministry of Education,Culture,Research,and Technology of the Republic of Indonesia through the Kedaireka 2022 Matching Fund Programme(Grant No.282/E1/KS.060.02/2022)。
The prevalence of stunting in Indonesian children under five years of age is approximately 20%.Chronic maternal malnutrition contributes to the risk of stunting by affecting global DNA methylation.In the present study...
关键词：global DNA methylation 5mC ELISA STUNTING COGNITIVE 
Use of DNA methylation patterns for early detection and management of lung cancer:Are we there yet?
《Oncology Research》2025年第4期781-793,共13页MILICA KONTIC FILIP MARKOVIC 
Detecting lung cancer early is crucial for improving survival rates,yet it remains a significant challenge due to many cases being diagnosed at advanced stages.This review aims to provide advances in epigenetics which...
关键词：Lung cancer DNA methylation EPIGENETICS HYPERMETHYLATION Early detection 
DNA damage triggers heritable alterations in DNA methylation patterns in Arabidopsis
《Molecular Plant》2025年第3期501-512,共12页Jinchao Li Wenjie Liang Xin-Qiang He Weiqiang Qian 
supported by the National Natural Science Foundation of China(grant no.32270288 to W.Q.;grant no.32400245 to J.L.);the China Postdoctoral Science Foundation(2024M760519 to W.L.);the Beijing Life Science Academy(2024500CA0010 to W.Q.).
It has been hypothesized that DNA damage has the potential to induce DNA hypermethylation,contributing to carcinogenesis in mammals.However,there is no sufficient evidence to support that DNA damage can cause genome-w...
关键词：DNA methylation RDDM DREAM DNA damage base excision repair 
Fecal methylated syndecan-2(SDC2)testing for early screening of colorectal cancerous and precancerous lesions:A real-world retrospective study in China
《Cancer Pathogenesis and Therapy》2025年第1期60-67,共8页Boyu Qin Haitao Niu upeng Qiu Hongfeng Zhou Peng Lyu 
Background:Colorectal cancer(CRC)is a major public health concern and the second leading cause of cancerrelated deaths worldwide.However,challenges remain in deploying effective screening strategies for early-stage CR...
关键词：Colorectal cancer Syndecan-2 DNA methylation DIAGNOSIS 
Catching cancer signals in the blood:Innovative pathways for early esophageal cancer diagnosis
《World Journal of Gastroenterology》2025年第10期1-6,共6页Yue Zhao Zhan Zhang Jian-Hao Qiu Rong-Yang Li Zhen-Guo Sun 
Supported by The National Key R and D Program of China,No.2021YFC2500904,No.2021YFC2500905 and No.2021YFC2500900;Shandong Provincial Natural Science Foundation,No.ZR2023MH130 and No.ZR2017BH035;China Postdoctoral Science Foundation,No.2020M672073;National Natural Science Foundation of China,No.81802397.
In recent years,significant progress has been made in the application of DNA methylation for the early detection of esophageal cancer(EC).As an epigenetic modification,DNA methylation allows for noninvasive screening ...
关键词：Esophageal cancer DNA methylation Circulating tumor DNA Early detection Liquid biopsy Treatment monitoring 
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