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DNA_METHYLATION: 作品数：656被引量：2197H指数：20; 导出分析报告; 相关作者：潘世扬陈龙邦杨音杨楠王锐更多>>; 相关机构：复旦大学南京军区南京总医院北京大学南京医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Epigenetic regulation of the inflammatory response in stroke: 《Neural Regeneration Research》2025年第11期3045-3062,共18页Jingyi Liang Fei Yang Zixiao Li Qian Li; supported by the National Natural Science Foundation of China,Nos.32070735(to QL),82371321(to QL),82171270(to ZL);Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1(to ZL);the Natural Science Foundation of Beijing,No.Z200016(to ZL);Beijing Talents Project,No.2018000021223ZK03(to ZL);Beijing Municipal Committee of Science and Technology,No.Z201100005620010(to ZL)。; Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either type.Immunologic mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytoki...; 关键词：DNA methylation histone modification intracerebral hemorrhage ischemic stroke NEUROINFLAMMATION NEUROPROTECTION non-coding RNA RNA methylation subarachnoid hemorrhage treatment

Maternal high-fat diet impairs offspring glucose metabolism and programs hepatic DNA methylation linked to NK cell-mediated cytotoxicity signaling pathway at weaning: 《Food Science and Human Wellness》2025年第4期1576-1587,共12页Sheng Zheng Ling Zhang Shixuan Zhang Guanyu Hu Yikai Li Jia Zheng; sponsored by National Natural Science Foundation of China(81800703);Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZC20231088);Beijing Nova Program(Z201100006820117 and 20220484181);Beijing Municipal Natural Science Foundation(7184252);the Fundamental Research Funds for the Central Universities;the Fundamental Research Funds for the Central Universities(BMU2021MX013);Peking University Clinical Scientist Training Program(BMU2023PYJH022);Peking University Medicine Seed Fund for Interdisciplinary Research;China Endocrine and Metabolism Young Scientific Talent Research Project(2022-N-02-01);China Diabetes Young Scientific Talent Research Project;Bethune-Merck Diabetes Research Fund of Bethune Charitable Foundation。; Maternal consumption of a high-fat diet has been linked to increased risks of obesity and impaired glucose metabolism in offspring.However,the precise epigenetic mechanisms governing these intergenerational effects,pa...; 关键词：Maternal high-fat diet consumption Glucose metabolism DNA methylation Natural killer cell-mediated cytotoxicity WEANING

MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B: 《World Journal of Diabetes》2025年第4期189-204,共16页Ying Yang Yi Chen Jian-Ying Tang Jian Chen Gui-Qing Li Bing Feng Jiao Mu; Supported by the Chongqing Basic Research and Frontier Exploration Project,No.cstc2018jcyjAX0834.; BACKGROUND At present,the incidence of diabetic nephropathy is increasing year by year,and there are many studies on the pathogenesis of diabetic nephropathy,but it is still not completely clear.The final pathological...; 关键词：Diabetic kidney disease Mir-29a-3p DNA methylation Janus kinase/signal transducer and activator of transcription WNT/Β-CATENIN Renal fibrosis

Dynamic DNA methylation modification in catechins and terpenoids biosynthesis during tea plant leaf development: 《Horticultural Plant Journal》2025年第2期906-920,共15页Jiahao Chen Yang Hu Zhangsheng Zhu Peng Zheng Shaoqun Liu Binmei Sun; supported by the Natural Science Foundation of Guangdong Province(Grant Nos.2022A1515111141 and 2023A1515010786)。; DNA methylation plays important roles in regulating gene expression during development.However,little is known about the influence of DNA methylation on secondary metabolism during leaf development in the tea plant(Ca...; 关键词：Camellia sinensis DNA methylation leaf development CATECHINS TERPENOIDS Gene regulation

Catching cancer signals in the blood:Innovative pathways for early esophageal cancer diagnosis: 《World Journal of Gastroenterology》2025年第10期1-6,共6页Yue Zhao Zhan Zhang Jian-Hao Qiu Rong-Yang Li Zhen-Guo Sun; Supported by The National Key R and D Program of China,No.2021YFC2500904,No.2021YFC2500905 and No.2021YFC2500900;Shandong Provincial Natural Science Foundation,No.ZR2023MH130 and No.ZR2017BH035;China Postdoctoral Science Foundation,No.2020M672073;National Natural Science Foundation of China,No.81802397.; In recent years,significant progress has been made in the application of DNA methylation for the early detection of esophageal cancer(EC).As an epigenetic modification,DNA methylation allows for noninvasive screening ...; 关键词：Esophageal cancer DNA methylation Circulating tumor DNA Early detection Liquid biopsy Treatment monitoring

Dietary modulation of epigenetics:Implications for cancer prevention and progression: 《Journal of Nutritional Oncology》2025年第1期8-15,共8页Si-Rui Zhu Xin-Yu Liang Qian Bai Xiang-Min Ni Jian Wang; Epidemiological studies indicate a strong correlation between various types of human cancer and dietary factors,whereas the specific mechanisms remain to be fully elucidated.Epigenetic alterations,such as DNA methylat...; 关键词：EPIGENETIC DNA methylation Histone modification Cancer DIET

Integrated multi-omics reveals contrasting epigenetic patterns in leaf and root morphogenesis in Aegilops speltoides: 《The Crop Journal》2025年第1期292-298,共7页Lingfeng Miao Zhe Chen Lifeng Gao Jizeng Jia Weilong Guo Guangyao Zhao; supported by the National Key Research and Development Program of China(2023YFD1200403).; Aegilops speltoides,the closest ancestor of the wheat B subgenome,has been well studied genomically.However,the epigenetic landscape of Ae.speltoides and the effects of epigenetics on its growth and development remain...; 关键词：Aegilops speltoides DNA methylation Histone modification Transcriptional regulatory network

New perspectives on DNA methylation modifications in ocular diseases: 《International Journal of Ophthalmology(English edition)》2025年第2期340-350,共11页Fei-Fei Zong Da-Dong Jia Guang-Kun Huang Meng Pan Hao Hu Shi-Yi Song Liang Xiao Ru-Weng Wang Liang Liang; The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular diseases.DNA methylation can regulate gene expression,thereby affecting cell function a...; 关键词：DNA methylation modification EPIGENETIC GLAUCOMA RETINOBLASTOMA diabetic retinopathy methylase inhibitors

Neoadjuvant HER2 inhibition induces ESR1 DNA methylation alterations resulting in clinically relevant ER expression changes in breast cancers: 《Cancer Communications》2025年第2期198-202,共5页Gavin P.Dowling Gordon R.Daly Aisling Hegarty Michael Flanagan Mihaela Ola Ramón Fallon Sinéad Cocchiglia Vikrant Singh Katherine M.Sheehan Fiona Bane Jason McGrath Louise Watson Sandra Hembrecht Bryan Hennessy Patrick G.Morris Arnold D.K.Hill Damir Varešlija Leonie S.Young; support from Science Foundation Ireland Frontiers for the Future Award(19/FFP/6443);Science Foundation Ireland Strategic Partnership Program,Precision Oncology Ireland(18/SPP/3522)(L.S.Y.);Breast Cancer Now Fellowship Award with the generous support of Walk the Walk(2019AugSF1310)(D.V.);Science Foundation Ireland(20/FFP-P/8597)(D.V.);Breast Cancer Ireland program Grant(18239A01)(L.S.Y.).; The expression of estrogen receptor(ER)and human epidermal growth factor receptor-2(HER2)in breast cancer can change in response to treatment and pivotally influence tumor behavior and clinical management[1].Receptor ...; 关键词：alterations HER2 BREAST

DNA methylation in the association between pesticide exposures and type 2 diabetes: 《World Journal of Diabetes》2025年第2期237-245,共9页Guang-Jun Zheng Zheng-Er Fang Bi-Ying Zhou Lei Zuo Xia Chen Ming-Liang Liu Lei Yu Chun-Xia Jing Guang Hao; BACKGROUND Numerous epidemiological studies have found that pesticide exposure is associated with the incidence of type 2 diabetes(T2D);however,the underlying mechanisms remain unknown.DNA methylation may play a role ...; 关键词：DNA methylation Pesticide exposure Type 2 diabetes GENE MECHANISMS

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