FLAGELLIN

作品数：31被引量：99H指数：6
导出分析报告
相关领域：医药卫生农业科学更多>>
相关作者：叶惟虎樊明文李宇红叶迎春王琳更多>>
相关机构：北京农林科学院武汉大学华中农业大学合肥工业大学更多>>
相关期刊：《Journal of Hainan Medical University》《Cellular & Molecular Immunology》《Frontiers in Biology》《Virologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划World Health Organization引进国际先进农业科技计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
蒜芥茄SsFLS2基因的克隆及其表达分析
《西南农业学报》2024年第8期1669-1676,共8页孙茂 吴丽艳 龚亚菊 鲍锐 桂敏 黎志彬 杜光辉 
云南省重大科技计划专项(202302AE090006);云南省农业基础研究联合专项面上项目(202301BD070001-052);国家自然科学基金项目(31960594);云南大学研究生科研创新基金项目(ZC-23234029)。
【目的】克隆云南野生蒜芥茄(Solanum sisymbriifolium Lam.)中的FLS2基因,并对其编码蛋白的理化性质、亚细胞定位、系统进化以及表达情况予以分析,初步探究野茄FLS2基因在黄萎病胁迫下的生物学功能。【方法】基于前期所测转录组数据(...
关键词：蒜芥茄 Flagellin sensing 2(FLS2) 基因克隆 生物信息学 基因表达 
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1被引量：1
《Signal Transduction and Targeted Therapy》2024年第5期2312-2323,共12页Xian Li Mengxin Xu Jingyi Yang Li Zhou Lin Liu Min Li Shasha Wang Mei-Qin Liu Zhixiang Huang Zhen Zhang Shuning Liu Yunqi Hu Haofeng Lin Bowen Liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen Huimin Yan Yao-Qing Chen 
National Key R&D program of China(Grant number:2022YFC2304204 to Y.-Q.C.,2021YFC2302602 to J.Y.);National Natural Science Foundation of China(grant number:82341041 to H.Y.and 92169104 to Y.-Q.C.);Shanghai Science and Technology Innovation Action Plan(Grant number:22Y11901000 to Q.W.);Shenzhen Science and Technology Program(Grant number:RCJC20210706092009004,JCYJ2020010914243811,KQTD20200820145822023 to Y.-Q.C.)supported this work in whole or in part.
Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic.Here,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple rece...
关键词：VACCINATION VACCINE SUSTAINED 
A triple-RBD-based mucosal vaccine provides broad protectionagainst SARS-CoV-2 variants of concern被引量：6
《Cellular & Molecular Immunology》2022年第11期1279-1289,共11页Jingyi Yang Mei-Qin Liu Lin Liu Xian Li Mengxin Xu Haofeng Lin Shuning Liu Yunqi Hu Bei Li Bowen Liu Min Li Ying Sun Yao-Qing Chen Zheng-Li Shi Huimin Yan 
This work was supported in whole or in part by the National Key R&D Program of China(grant number:2021YFC2302602 to JY);the strategic priority research program(grant number XDB29010101);key project(2020YJFK-Z-0149)of the Chinese Academy of Sciences(to Z-LS);This study was also supported by the National Natural Science Foundation of China(31970878 to JY,92169104 and 31970881 to Y-QC),Shenzhen Science and Technology Program (Grant number: RCJC20210706092009004 and JCYJ20190807154603596 to Y-QC).
The rapid mutation and spread of SARS-CoV-2 variants urge the development of effective mucosal vaccines to provide broadspectrum protection against the initial infection and thereby curb the transmission potential.Her...
关键词：SARS-CoV-2 Mucosal vaccine Intranasal immunization Triple-RBD Flagellin adjuvant Variant of concern 
Effect of Acacetin on flagellin induced NLRC4 inflammasome activation in mouse bone marrow-derived macrophages
《Journal of Hainan Medical University》2022年第17期14-17,共4页Wang Zhao-xia Bu Juan Zhang Xiao-ling MAHAN Yeledan Wu Xuan-xia Zhou ling 
Xinjiang Uygur Autonomous Region Natural Science Foundation(No.2020D01C095);Xinjiang Uygur Autonomous Region Outstanding Young Scientist and Technological Talents Training Project(No.2020Q046);Xinjiang Uygur Autonomous Region People's Hospital In-Hospital Project(No.20210102)。
Objective:To investigate the effect of acacetin on flagellin induced NLRC4 inflammasome activation in mouse bone marrow-derived macrophages(BMDMs).Methods:Mouse BMDMs were divided into control group,LPS group,LPS+flag...
关键词：FLAGELLIN ACACETIN NLRC4 ACTIVATION MACROPHAGES 
Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment被引量：10
《Acta Pharmaceutica Sinica B》2021年第10期3165-3177,共13页Jianxiang Chen Yiting Qiao Guo Chen Cunjie Chang Heng Dong Bo Tang Xiawei Cheng Xiufeng Liu Zichun Hua 
supported by grants from the Jiangsu Provincial Nature Science Foundation(BK20192005,China);National Natural Science Foundation of China(81630092,81903143,81802338,and 82072646);Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars(LR21H160001);Start-up Grant of HZNU(4125C5021820470,China)。
Salmonella:mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models,but the detailed mechanism remains unsolved.In this report,the active involvement of the host immune response...
关键词：Bacteria-mediated cancer therapy SALMONELLA VNP20009 FLAGELLUM FLAGELLIN TLR5 NF-kB Cancer immune therapy 
Twisting mode of supercoil leucine-rich domain mediates peptide sensing in FLS2–flg22–BAK1 complex
《Chinese Physics B》2020年第10期56-65,共10页Zhi-Chao Liu Qin Liu Chan-You Chen Chen Zeng Peng Ran Yun-Jie Zhao Lei Pan 
Project supported by the National Natural Science Foundation of China (Grant No. 11704140);self-determined research funds of CCNU from the Colleges' Basic Research and Operation of MOE (Grant No. CCNU20TS004) (Y. Z.);the China Scholarship Council Fund (Grant No. 201708420039) (L. P.).
Plants and animals recognize microbial invaders by detecting pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs). This recognition plays a crucial role in plant immunity. The ne...
关键词：plant immunity flagellin-sensitive 2 peptide sensing mechanism 
BAK1-mediated phosphorylation of canonical G protein alpha during flagellin signaling in Arabidopsis被引量：5
《Journal of Integrative Plant Biology》2020年第5期690-701,共12页Jiao Xue Ben-Qiang Gong Xinran Yao Xiangjuan Huang Jian-Feng Li 
supported by the National Natural Science Foundation of China(31770295 and 31570276)。
Heterotrimeric G proteins consisting of Gα,Gβand Gγare conserved signaling hubs in eukaryotes.Without analogs to canonical animal G protein-coupled receptors,plant cells are thought to use RGS1 and a yet unknown me...
关键词：PHOSPHORYLATION ARABIDOPSIS IMMUNITY 
Molecular cloning and functional identification of an apple flagellin receptor MdFLS2 gene被引量：1
《Journal of Integrative Agriculture》2018年第12期2694-2703,共10页QI Chen-hui ZHAO Xian-yan JIANG Han LIU Hai-tao WANG Yong-xu HU Da-gang HAO Yu-jin 
supported by the National Natural Science Foundation of China(31601728 and 31430074);the Ministry of Education of China(IRT15R42);the Natural Science Foundation of Shandong Province,China(ZR2016CQ13 and SDAIT-06-03);the Young Scientists Funds of Shandong Agricultural University,China(564024 and 24024)
The leucine-rich repeat receptor kinase flagellin-sensing 2 gene(MdFLS2; Gene ID: MDP0000254112) was cloned from Royal Gala apple(Malus×domestica Borkh.). This gene contained a complete open reading frame of 3 474 bp...
关键词：APPLE flagellin receptor flagellin elicitor peptide MdFLS2 pathogen infection 
AEG-1肺归巢域与Flagellin融合基因的杆状病毒制备及鉴定
《中国实验诊断学》2018年第10期1807-1812,共6页王希 王琳 张喆 龙敏 董轲 张惠中 
国家自然科学基金资助项目(81572974);陕西省科技创新项目(2016ktzdsf01-07)
目的通过重叠PCR方法获得AEG-1C-Flic融合基因,采用Bac-To-Bac杆状病毒表达系统获得重组AEG-1C-Flic杆状病毒,为后续AEG-1C-Flic病毒样颗粒疫苗的制备奠定基础。方法从鼠伤寒沙门菌的基因组中PCR扩增细菌鞭毛蛋白Flagellin,采用重叠PCR...
关键词：病毒样颗粒 AEG-1 肺归巢域 FLAGELLIN 
Structural basis for specific flagellin recognition by t ~ILR protein NAIP5被引量：3
《Cell Research》2018年第1期35-47,共13页Xinru Yang Fan Yang Weiguang Wang Guangzhong Lin Zehan Hu Zhifu Han Yijun Qi Liman Zhang Jiawei Wang Sen-Fang Sui Jijie Chai 
We thank Jianlin Lei, Yanji Xu and Xiaomei Li for EM sup- port, the Tsinghua University Cryo-EM Facility of China National Center for Protein Sciences （Beijing） of the Tsinghua National Laboratory： for Information Science and Technology for EM re- sources, Tao Yang and Yakun Wang at Tsinghua University Branch of China National Center for protein Sciences Beijing for compu- tational support, the computational facility for support of the clus- ter of Bio-Computing Platform （Tsinghua University Branch of China National Center for Protein Sciences Beijing）. The research was funded by the Chinese Ministry of Science and Technology （2014CB910101 to JC, 2016YFA0501101 and 2017YFA0504600 to S-FS）, the National Natural Science Foundation of China （31230016, 31370717 and 31670745 to S-FS）, Alexander yon Humboldt-Foundation （Humboldt Professorship to JC） and Max- Planck-Gesellschaft （Max Planck Fellow to JC）.
The nucleotide-binding domain- and leucine-rich repeat （LRR）-containing proteins （NLRs） function as intracel- lular immune receptors to detect the presence of pathogen- or host-derived signals. The mechanisms of h...
关键词：Structural basis specific flagellin NAIP5 
全选清除导出
共4页<1234>
检索报告 对象比较 聚类工具 使用帮助 返回顶部