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Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity
《Neural Regeneration Research》2024年第10期2095-2096,共2页Alessandro Cembran Pedro Fernandez-Funez 
supported by the NIH grant7R21 NS09662 7-02 to PFF;the Winston and Maxine Wallin Neuroscience Discovery Fund award CON000000083928 to PFF and AC。
The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal outcomes.Prion diseases are rare but deserve special attention because of the...
关键词：FOLDING INTRINSIC DYNAMICS 
Imaging mass spectrometry:a molecular microscope for studying the role of lipids in Parkinson's disease
《Neural Regeneration Research》2024年第6期1179-1180,共2页Vinata Vedam-Mai Jacob M.Samuel Boone M.Prentice 
Parkinson's disease–A lipidopathy?The histopathological hallmark of Parkinson's disease(PD)and dementia with Lewy bodies are inclusions enriched inα-synuclein(α-syn),known as Lewy bodies,which are not only composed...
关键词：LIPIDS SPECIES FOLDING 
Engineering cerebral folding in brain organoids被引量：1
《Neural Regeneration Research》2022年第11期2420-2422,共3页Glen Scott Yu Huang 
partially USU's Engineering Undergraduate Research Program;partially NIH NIGMS fund,No.R15GM132877;partially NIH NIGMS fund.No.R35GM143194。
Valuable implement to the animal neurological models:Neurological diseases remain the largest cause of death and disability.The discovery of effective therapies is chiefly hindered by the lack of realistic neurologica...
关键词：CEREBRAL DISEASES 
Exploiting Caenorhabditis elegans to discover human gut microbiota-mediated intervention strategies in protein conformational diseases
《Neural Regeneration Research》2022年第10期2203-2204,共2页Daniel M.Czyż 
supported by The National Institutes of Health(R03AG069056-02,R03AG070580-01);Infectious Diseases Society of America(to DMC).
Age-dependent protein-conformational diseases(PCDs),such as Alzheimer’s disease(AD),Parkinson’s disease(PD),or amyotrophic lateral sclerosis(ALS),are characterized by misfolding and aggregation of metastable protein...
关键词：DISEASES ALZHEIMER FOLDING 
The role of the unfolded protein response in myelination被引量：1
《Neural Regeneration Research》2016年第3期394-395,共2页Michelle C.Naughton Jill M.McMahon Una F.FitzGerald 
The production,transport and integration of myelin components into the membrane during development is a highly coordinated and regulated process that relies heavily on the endoplasmic reticulum（ER）,a sub-cellular or...
关键词：endoplasmic translational reticulum prior folding assembly coordinated myelin correct tracts 
The roles of tubulin-folding cofactors in neuronal morphogenesis and disease
《Neural Regeneration Research》2015年第9期1388-1389,共2页Misako Okumura Masayuki Miura Takahiro Chihara 
supported by grants from the Ministry of Education,Culture,Sports,Science and Technology in Japan to MM and TC;the Japan Society for the Promotion of Science to MO,MM,and TC;the Japan Science and Technology Agency to M.M.and TC
Microtubules play important roles in neuronal morphogenesis, including cellular polarization, neurite growth, and branching. A microtubule is a polymer of a- and β-tubulin heterodimers that are formed by a multistep ...
关键词：The roles of tubulin-folding cofactors in neuronal morphogenesis and disease Figure 
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