GENE_SILENCING

作品数：162被引量：627H指数：11
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Effective gene silencing in Drosophila ovarian germline by artificial microRNAs被引量：3
《Cell Research》2011年第4期700-703,共4页Hailong Wang YanJun Mu Dahua Chen 
Dear Editor, Drosophila oogenesis is of great interest because it represents an excellent model system to study a number of fascinating biological processes, such as stem cell regulation, germ cell meiosis and oocyte...
关键词：生殖细胞 小分子RNA 卵巢管 基因沉默 果蝇 人工 生物过程 模型系统 
iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability被引量：1
《Cell Research》2010年第10期1092-1095,共4页Veronica Ramos-Mejla Martin Mufioz-Lopez Jose L Garcia-Perez Pablo Menendez 
Here, we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells （iPSCs） may predispose iPSCs to genomic instabili...
关键词：iPSCs genomic stability reprogramming factors gene silencing 
Arabidopsis thaliana histone deacetylase1(AtHD1)is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro被引量：6
《Cell Research》2006年第5期479-488,共10页Paulus M Fong Lu Tian Z Jeffrey Chen 
We thank Mary Bryk and Timothy Hall for critical suggestions to improve the manuscript,David Stelly and Keerti Rathore for assistance in GFP localization studies in onion cells,and Stanislav Vitha in the Microscopy and Imaging Center at Texas A&M University for technical support for epifluorescence microscopic image analysis in the transgenic plants.The work is supported by grants from the National Institutes of Health(GM067015);the National Science Foundation Plant Genome Research Program(DBI0077774)to Z J C.
Arabidopsis thaliana histone deacetylase 1 （AtHD1 or AtHDA19）, a homolog ot yeast RPD3, is a global regulator ot many physiological and developmental processes in plants. In spite of the genetic evidence for a role ...
关键词：ARABIDOPSIS histone deacetylase RPD3 subcellular localization gene silencing CHROMATIN 
Approaches to functional genomics in filamentous fungi被引量：20
《Cell Research》2006年第1期31-44,共14页Richard J Weld Kim M Plummer Margaret A Carpenter Hayley J Ridgway 
The study of gene function in filamentous fungi is a field of research that has made great advances in very recent years. A number of transformation and gene manipulation strategies have been developed and applied to ...
关键词：functional genomics gene replacement filamentous fungi homologous recombination RNAI gene silencing OOMYCETES 
Gene silencing in Xenopus laevis by DNA vector-based RNA interference and transgenesis
《Cell Research》2006年第1期99-105,共7页Ming Li Baerbel Rohrer 
A vector-based RNAi expression system was developed using the Xenopus tropicalis U6 promoter, which transcribes small RNA genes by RNA polymerase Ⅲ. The system was first validated in a Xenopus laevis cell line, desig...
关键词：RNAi Xenopus U6 promoter TRANSGENIC Xenopus laevis GFP 
Dynamic and reversibility of heterochromatic gene silencing in human dis-ease被引量：5
《Cell Research》2005年第9期679-690,共12页Giuseppe ZARDO Francesco FAZI Lorena TRAVAGLINI Clara NERVI 
In eukaryotic organisms cellular fate and tissue specific gene expression are regulated by the activity of proteins known as transcription factors that by interacting with specific DNA sequences direct the activation ...
关键词：真核细胞 人类疾病 基因抑制 目标基因 遗传因素 
Methyl-CpG binding proteins in the nervous system被引量：7
《Cell Research》2005年第4期255-261,共7页Leah HUTNICK 
Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain(MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional re...
关键词：MECP2 MBD proteins DNA methylation neuronal differentiation chromatin remodeling gene silencing histone modification. 
Gene silencing:Double-stranded RNA mediated mRNA degradation and gene inactivation被引量：2
《Cell Research》2001年第3期181-186,共6页TangW LuoXY 
The recent development of gene transfer approaches in plants and animals has revealed that transgene can undergo silencing after integration in the genome. Host genes can also be silenced as a consequence of the prese...
关键词：Gene silencing double-stranded RNA METHYLATION homologous RNA transgene. 
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