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Restoration of Brain Acid Soluble Protein 1 Inhibits Proliferation and Migration of Thyroid Cancer Cells被引量：2: 《Chinese Medical Journal》2016年第12期1439-1446,共8页Run-Sheng Guo Yue YU Jun Chen Yue-Yu Chen Na Shen Ming Qiu; Background： Brain acid soluble protein 1 （BASPI） is identified as a novel potential tumor suppressor in several cancers. However, its role in thyroid cancer has not been investigated yet. In the present study, the ...; 关键词：Brain Acid Soluble Protein 1 Gene Transfection PROLIFERATION Thyroid Cancer

Ultrasonic destruction of albumin microbubbles enhances gene transfection and expression in cardiac myocytes被引量：2: 《Chinese Medical Journal》2011年第9期1395-1400,共6页WANG Guo-zhong LIU Jing-hua LUE Shu-zheng LUE Yun GUO Cheng-jun ZHAO Dong-hui FANG Dong-ping HE Dong-fang ZHOU Yuan GE Chang-jiang; Background It has been proven that ultrasonic destruction of microbubbles can enhance gene transfection efficiency into the noncardiac cells, but there are few reports about cardiac myocytes. Moreover, the exact mecha...; 关键词：ultrasound MICROBUBBLES gene transfer cardiac myocytes

Transplantation of VEGF165-gene-transfected endothelial progenitor cells in the treatment of chronic venous thrombosis in rats被引量：14: 《Chinese Medical Journal》2010年第4期471-477,共7页MENG Qing-you LI Xiao-qiang YU Xiao-bin LEI Feng-rui JIANG Kun LI Chuan-yong; This work was supported by a grant from the Natural Science Foundation of Jiangsu Province （No. BK2007055）.; Background The organization and recanalization of thrombi is a dynamic and complex process. The aim of this research was to study the cotherapeutic effect of stem cell transplantation and gene transfection on chronic ...; 关键词：vascular endothelial growth factor endothelialprogenitor cell gene transfection ADENOVIRUS venous thrombosis

Effect of recombinant adenovirus vector mediated human interleukin-24 gene transfection on pancreatic carcinoma growth被引量：8: 《Chinese Medical Journal》2008年第20期2031-2036,共6页PAN Xin-ting ZHU Qing-yun LI De-chun YANG Ji-cheng ZHANG Zi-xiang ZHU Xing-guo ZHAO Hua; This work was supported by a grant from the Science Foundation of the Ministry of Health of China （No. WKJ2004-2-011）.; Background Pancreatic cancer is a highly malignant tumor affecting an ever increasing number of patients with a mean 5-year survival rate below 4%. Therefore, gene therapy for cancer has become a potential novel thera...; 关键词：INTERLEUKIN-24 ADENOVIRUS pancreatic carcinoma gene therapy ANGIOGENESIS apoptosis

Effect of vascular endothelial growth factor 165 gene transfection on bone defects and its mRNA expression in rabbits被引量：11: 《Chinese Medical Journal》2007年第13期1187-1191,共5页ZHAO Dong-mei WANG Hai-bin YANG Jia-feng WU Shi-qing LIU Jun-li XU Fu-yu QIU Li-ping CAI Jing-long; Science and Technology Key Projects Program (No. 032050112); Natural Science Fundation (No.Q2006C08)of Shandong Province;Health Department of Shandong Province Projects Program (No. 2003); Background Gene therapy has been a hot spot in repair of bone defects in recent years. This study aimed to construct a recombinant plasmid pcDNA3.1-VEGF165, and to observe the effect of vascular endothelial growth fac...; 关键词：gene transfection vascular endothelial growth factor bone defects

Heat shock protein 70 gene transfection protects rat myocardium cell against anoxia-reoxygeneration injury被引量：5: 《Chinese Medical Journal》2007年第7期578-583,共6页LIU Ji-chun HE Ming WAN Li CHENG Xiao-shu; Background A number of studies suggest that the expression of heat shock protein 70 （HSP70） induced by heat stress are associated with protection against ischemia-reperfusion injury. But the protective effects may b...; 关键词：gene transfection HSP70 gene NF-κB cardiac myocyte anoxia-reoxygeneration injury

Effects of recombinant retroviral vector mediated human insulin like growth factor-1 gene transfection on skeletal muscle growth in rat被引量：10: 《Chinese Medical Journal》2006年第23期1991-1998,共8页RONG Shu-Ling LU Yong-Xin LIAO Yu-Hua WANG Xiao-Lin GUO He-Ping CHANG Chao GAO Yan-Zhang MI Shao-Hua Wan Jian-Ping; This work was supported by a grant from the National Natural Science Foundation of China (No.30470457).; Background This study transferred a recombinant gene encoding human insulin like growth factor-1 （hIGF-1） into modified primary skeletal myoblasts with a retroviral vector （pLgXSN） and determined whether the hIGF-...; 关键词：insulin like growth factor-1 skeletal muscle growth retroviral vector

Effects of secretive bone morphogenetic protein 2 induced by gene transfection on the biological changes of NIH3T3 cells被引量：3: 《Chinese Medical Journal》2005年第20期1703-1709,共7页SUN Wei-bin WANG Juan LU Chun TANG Gui-xia; This work is supported by grants from 135 Medical EmphasisFoundation of Jiangsu Province (RC 2002018) and Natural Scienceand Technology Foundation of Nanjing Medical University(CX2003006).; Background Bone morphogenetic proteins （BMPs）, which belong to the transforming growth factor beta superfamily, are powerful regulators of cartilage and bone formation. This study investigated the biological changes...; 关键词：guided periodontal tissue regeneration bone morphogenetic protein 2 ultrastructure ·alkaline phosphatase OSTEOCALCIN

Anti-tumor effect of recombinant retroviral vector-mediated human ANGPTL4 gene transfection被引量：6: 《Chinese Medical Journal》2004年第9期1364-1369,共6页李克强李文林彭淑牖石小玉唐洪林刘颖斌; Background This study was designed to obtain a recombinant retroviral vector containing the human hepatocellular carcinoma-related gene ANGPTL4 (angiopoietin-like 4) cDNA and to evaluate the anti-tumor effect of reco...; 关键词：angiopoietin-like 4 · HepG 2 cell · retroviral vector

Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit被引量：40: 《Chinese Medical Journal》2003年第10期1544-1548,共5页杨操杨述华杜靖远李进许伟华熊宇芳; ThisstudywassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina (No 3 0 170 945 ); Objective To explore a new method for the therapy of avascular necrosis of the femoral head. Methods The recombinant plasmid pCD-hVEGF 165 was mixed with collagen and was implanted in the necrotic femoral head. The...; 关键词：vascular endothelial growth factor gene transfection avascular necrosis femoral head

GENE_TRANSFECTION