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GENE_TRANSFER: 作品数：204被引量：510H指数：11; 导出分析报告; 相关作者：王晶江洪黄从新李庚山李建军更多>>; 相关机构：武汉大学中国医学科学院阜外心血管医院大连民族大学青岛大学医学院附属医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划湖北省自然科学基金更多>>

Donor MHC gene to mitigate rejection of transplantation in recipient mice被引量：2: 《Chinese Medical Journal》2011年第24期4279-4285,共7页LI Tong YAN Jun TAN Jia-li LU Yue-ping HOU Sheng-cai LI Shen-tao XU Qing TONG Xue-hong DING Jie ZHANG Zhi-tai LI Hui; Background Donor organ rejection continues to be a significant problem for patients receiving transplants. We therefore tested whether transferring a donor＇s major histocompatibility complex （MHC） gene to the recip...; 关键词：major histocompatibility complex TRANSPLANTATION gene transference TOLERANCE

Ultrasonic destruction of albumin microbubbles enhances gene transfection and expression in cardiac myocytes被引量：2: 《Chinese Medical Journal》2011年第9期1395-1400,共6页WANG Guo-zhong LIU Jing-hua LUE Shu-zheng LUE Yun GUO Cheng-jun ZHAO Dong-hui FANG Dong-ping HE Dong-fang ZHOU Yuan GE Chang-jiang; Background It has been proven that ultrasonic destruction of microbubbles can enhance gene transfection efficiency into the noncardiac cells, but there are few reports about cardiac myocytes. Moreover, the exact mecha...; 关键词：ultrasound MICROBUBBLES gene transfer cardiac myocytes

Inhibition of rejection in murine islet xenografts by CTLA41g and CD40LIg gene transfer被引量：5: 《Chinese Medical Journal》2010年第21期3106-3109,共4页ZHANG Jian LI Hua JIANG Nan WANG Guo-ying FU Bin-sheng WANG Gen-shu YANG Yang CHEN Gui-hua; Background Costimulatory signals play a vital role in T cell activation. Blockade of costimulatory pathway by CTLA4Ig or CD40LIg have enhanced graft survival in experimental transplantation models yet mechanisms remai...; 关键词：transplantation islet of Langerhans CTLA4IG CD40LIg immune tolerance

Improvement in cardiac function after sarcoplasmic reticulum Ca^2＋-ATPase gene transfer in a beagle heart failure model被引量：8: 《Chinese Medical Journal》2009年第12期1423-1428,共6页MI Ya-fei LI Xiao-ying TANG Li-jiang LU Xiao-chun FU Zhi-qing YE Wei-hua; This work was supported by grants from the China ＂973＂ plan （No. 2006CB503806）, and the National Science Foundation of China （No. 30600236）.; Background Heart failure （HF） is a major cause of morbidity and mortality worldwide, but current treatment modalities cannot reverse the underlying pathological state of the heart. Gene-based therapies are emerging ...; 关键词：heart failure gene therapy sarco-endoplasmic reticulum calcium ATPase

Effects of human interleukin 10 gene transfer on the expression of Bcl-2 Bax and apoptosis of hepatocyte in rats with acute hemorrhagic necrotizing pancreatitis被引量：4: 《Chinese Medical Journal》2005年第19期1658-1660,共3页GU Jun-chao WANG Yu ZHANG Zhong-tao XUE Jian-guo LI Jian-she ZHOU Yan-zhong; ThisworkwassupportedbyBeijingNewStarsofTechnologyProject (No.[2000]91)andNationalNaturalScienceFoundationofChina (No.30271264).; Acute necrotising pancreatitis is characterized by inflammatory and necrotic events, which followthe initial intra-acinar injury involving enzyme activation, and disruption of the acinar cytoskeleton. At present, apo...; 关键词：acute necrotizing pancreatitis cell apoptosis interleukin 10 gene transfer

Effects of adenovirus mediated vascular endothelial growth factor gene transfer on reconstitution of hematopoiesis in post-bone marrow transplantation mice被引量：1: 《Chinese Medical Journal》2005年第4期289-295,共7页ZHONGZhao-dong ZOUPing HUXian-shi YOUYong CHENZhi-chao HUANGShi-ang; ThisstudywassupportedbyagrantfromtheOverseaOutstandingYoungScholarAwardoftheNationalNaturalScienceFoundationofChina(No 39928010); Background Bone marrow transplantation ( BMT) conditioning procedure isconsidered as the cause of damage to bone marrow microvasculature and the delay of hematopoiesisrecovery. However, hematopoiesis regulation post B...; 关键词：vascular endothelial growth factor gene transfer bone marrowtranspbntation reconstitution of hematopoiesis

Effect of human hepatocyte growth factor on promoting wound healing and preventing scar formation by adenovirus-mediated gene transfer被引量：21: 《Chinese Medical Journal》2003年第7期1029-1033,共5页哈小琴李元敏劳妙芬苑宾吴祖泽; theStateHigh TechnologyDepartmentProgram (No 2 0 0 1AA2 170 61);partlybyagrantfromtheBiologicalEngineeringDepartment;FarEastAreaofAmericanBaxterHealthcareProductsCo Ltd ;USA; Objective To evaluate the effects of hepatocyte growth factor (HGF) on the prevention of scar formation and the promotion of wound healing by gene transfer Methods A total of 12 female New Zealand rabbits were use...; 关键词：scar · wound healing · hepatocyte growth factor · gene transfer · adenoviral vector

Tumor cell-specific gene transfer with retroviral vectors displaying single-chain antibody: 《Chinese Medical Journal》2002年第7期1064-1069,153,共6页汤宇澄李煜钱关祥; ThisresearchissupportedbyNationalScienceFoundationofChina(No .863 Z2 0 0 1 0 4); OBJECTIVE: To specifically deliver the therapeutic gene to cancer cells and construct target retroviral vectors by inserting the single-chain variable antibody fragment into the retroviral envelope. METHODS: Single-ch...; 关键词：Gene Therapy Gene Transfer Techniques Genetic Vectors Hela Cells Humans Immunoglobulin Fragments NEOPLASMS Research Support Non-U.S. Gov't RETROVIRIDAE

Vascular endothelial growth factor gene transfer improves host endothelialization of xenogeneic biologic heart valve in vivo: 《Chinese Medical Journal》2002年第6期878-883,153,共6页张中明董红燕刘金东王伟胡波; agrantfromtheEducationAssociationofJiangsuProvince ,China (No .98JKB32 0 0 0 8); OBJECTIVE: To investigate the feasibility of endothelialization of bioprosthesis by transfer of vascular endothelial growth factor (VEGF) gene. METHODS: Bovine pericardium treated with glutaraldehyde and L-glutamic ac...; 关键词：BIOPROSTHESIS Heart Valve Prosthesis Animals Endothelial Growth Factors Endothelium Vascular Female Gene Transfer Techniques Humans LYMPHOKINES Male RNA Messenger Research Support Non-U.S. Gov't Swine Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors

Comparative study of catheter-mediated gene transfer into heart: 《Chinese Medical Journal》2002年第4期612-613,共2页李建军李庚山黄从新江洪唐基柱许家俐夏豪王晶; 教育部留学回国人员科研启动基金; OBJECTIVE: To investigate the feasibility and features of 3 catheter-mediated approaches of gene transfer into heart, including direct myocardial injection (DMI), coronary artery perfusion (CAP), and intrapericardial ...; 关键词：Gene Transfer Techniques ADENOVIRIDAE Animals Comparative Study Dogs Female Gene Expression Genetic Vectors Heart Catheterization Inflammation INJECTIONS Lac Operon Liver Male MYOCARDIUM Research Support Non-U.S. Gov't

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