HEPATOCYTE

作品数：324被引量：1213H指数：17
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相关机构：北京大学南方医科大学福建医科大学中国药科大学更多>>
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Learning human liver biology in humanized mice
《Cell Research》2024年第1期9-10,共2页Brandon M.Lehrich P.Monga 
A new study describes development of a chimeric mouse liver repopulated with nearly all human hepatic cell types albeit to varying extents.This model yielded novel information on unique human hepatocyte metabolic func...
关键词：LIVER HEPATIC HEPATOCYTE 
An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression被引量：11
《Cell Research》2023年第8期585-603,共19页Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou 
the National Center for Protein Science Shanghai and China National GeneBank for assistance with microscopy.This work was jointly supported by the National Key R&D Program of China(2019YFC1315800,2019YFC1315802,and 2021YFC2501900);the State Key Program of the National Natural Science of China(81830102);the Original Discovery Program of the National Natural Science of China(82150004);the National Natural Science Foundation of China(82341027,81772578,81772551,81872355,81830102,81802991,82150004,and 82072715);the Shanghai Municipal Science and Technology Major Project,the Guangdong Basic and Applied Basic Research Foundation(2021A1515110832);the Shanghai Municipal Health Commission Collaborative Innovation Cluster Project(2019CXJQ02 and 201940075);the Shanghai Municipal Health Commission(2022LJ005);the Shanghai Science and Technology Commission(21140900300);the Shenzhen Key Laboratory of Single-Cell Omics(ZDSYS20190902093613831).
Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor me...
关键词：INVASION metastasis STEREO 
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors被引量：4
《Cell Research》2019年第2期124-135,共12页Zhuo Cheng Zhiying He Yongchao Cai Cheng Zhang Gongbo Fu Hengyu Li Wen Sun Changcheng Liu Xiuliang Cui Beifang Ning Daimin Xiang Tengfei Zhou Xiaofeng Li Weifen Xie Hongyang Wang Jin Ding 
grants from the State Key Project of China (2017YFA0504503);the National Natural Science Foundation of China (81772582,81572897 and 81471948);the Shanghai Pujiang Program (17PJD045);Key Project of Shanghai Science and Technology Committee (17431906600).
Normal cells become cancer cells after a malignant transformation,but whether cancer cells can be reversed to normal status remains elusive.Here,we report that the combination of hepatocyte nuclear factor IA (HNFIA),H...
关键词：CONVERSION HEPATOMA CELLS hepatocyte-like CELLS 
Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion被引量：14
《Cell Research》2017年第5期709-712,共4页Wu, Han Zhou, Xu Fu, Gong-Bo He, Zhi-Ying Wu, Hong-Ping You, Pu Ashton, Charles Wang, Xin Wang, Hong-Yang Yan, He-Xin 
Dear Editor, Liver exhibits robust regeneration following mechan- ical damage due to immediate proliferation of hepato- cytes. It has been recently reported that hepatocyte re- plenishment following liver damage coul...
Probing hepatocyte heterogeneity被引量：3
《Cell Research》2015年第11期1181-1182,共2页Ben Z Stanger 
To maintain homeostasis, organs replace cells lost through normal cellular turnover, often through the straightforward replication of exist- ing cells. A recent paper in Nature shows that cells in the liver are not eq...
关键词：细胞异质性 肝细胞 体内平衡 WNT 复制 
ERK1/2 contributes negative regulation to STAT3 activity in HSS-transfected HepG2 cells被引量：3
《Cell Research》2004年第2期141-147,共7页ZeJunTIAN WeiAN 
This work was supported by the National Natural Science Foundation of China(No.39870285,No.0070342).
Signal transducer and activator of transcription 3 (STAT3) is a recently characterized transcription factor which is essential to liver regeneration. We have previously reported that hepatic stimulator substance (HSS)...
关键词：hepatic stimulator substance ERK1/2 STAT3 hepatocyte growth. 
Ultracytochemical localization of H+-adenosine triphosphatase activity in autophagic vacuoles induced by vinblastine in rat liver
《Cell Research》1990年第2期207-215,共9页LUOSHENQIU MASAHIROSAKAI 等 
H+-adenosine triphosphatase (H+-ATPase) activity was demonstrated oytoohemioally in autophagio vaouoles (AVs) of rat hepatooytes using a modification of the method for the demonstration of neutral p-nitrophenyl phosph...
关键词：RAT HEPATOCYTE AUTOPHAGY H+-ATPase. 
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