the National Key Project for Basic Research of China (Grant No. 2005CB522702);State 863 High Technology R&D Project of China (Grant No. 2006AA02A107);the National Natural Science Foundation of China (Grant No. 30671098)
Hepatocyte transplantation and bioartificial liver (BAL) as alternatives to liver transplantation offer the possibility of effective treatment for many inherited and acquired hepatic disorders. Unfortunately, the limi...
Complex 3-dimensional structures with good functions have been obtained under the primary mixcoculture of mouse hepatocytes with mouse liver fibroblasts without serum. Albumin secretion is kept above 10 μg/106 cells ...
Aggregation of freshly isolated adult rat hepatocytes in vitro is important for the construction of artificial liver support system. In the experiment, agar has been used as an extracellular matrix substrate and resul...
Fulvic acid (FA), a soluble fraction of the humic adds, is a group of polymers with a number of quinone moieties. It induces oxidative damage to cell, resulting in reduction of GSH-Px activity and increase of SOD acti...
Gangliosides and phospholipids (PL) are important constituents of cell-surface membranes. Our recent results showed that ganglioside GM3 significantly influence the phospholipid composition and metabolism of a human m...
Recently, collagen fibril formation by liver parenchymal cells has been reported.Whether hepatoeytes in situ produce collagen is not determined. The present letter reports that using light and electron microscopes, we...