The cryo-EM data were collected at the Cryo-Electron Microscopy Research Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences.We thank the staff of the National Center for Protein Science(Shanghai)Electron Microscopy facility for instrument support.This work was partially supported by the Ministry of Science and Technology of China(2018YFA0507002 to H.E.X.and 2018YFA0507000 to M.-W.W.);the National Natural Science Foundation of China(31770796 to Y.J.,81872915 and 82073904 to M.-W.W.,81773792 and 81973373 to D.Y.);National Science and Technology Major Project of China-Key New Drug Creation and Manufacturing Program(2018ZX09711002-002-002 to Y.J.,2018ZX09735-001 to M.-W.W.,and 2018ZX09711002-002-005 to D.Y.);the Shanghai Municipal Science and Technology Commission Major Project(2019SHZDZX02 to H.E.X.);the CAS Strategic Priority Research Program(XDB37030103 to H.E.X.);Novo Nordisk-CAS Research Fund(NNCAS-2017-1-CC to D.Y.).
Melanocortins are peptide hormones critical for the regulation of stress response,energy homeostasis,inflammation,and skin pigmentation.Their functions are mediated by five G protein-coupled receptors(MC1R–MC5R),pred...
supported by the National Basic Research Program(973)of China(Nos.2013CB127301 and 2013CB127304);the Guangdong International Science and Technology Cooperation Program(No.2014A050503049);the China Agriculture Research System(No.CARS-36);the Science and Technology Program of Guangdong Province(Nos.2013A061401020 and 2016A020210041),China
To investigate dietary protein level effects on digestive mechanisms, weaned piglets were fed for 45 d with diets containing 20%, 17%, or 14% crude protein (CP) supplemented to meet requirements for essential amino ...
This work was supported by National Key Basic Research and Development Program Grant 2011 CB100700 (to Z.H.); Natural Science Foundation of China Grants 91117018 and 30730064 (to Z.H.);and US Department of Agriculture National Research Initiative Grant 2003-35319-17873 (to Y.Y.). No conflict of interest declared.
ABSTRACT Plant hormones have been extensively studied for their importance in innate immunity particularly in the dicotyledonous model plant Arabidopsis thaliana. However, only in the last decade, plant hormones were ...
We are grateful to the staff and volunteer participants for their close cooperation and significant contributions. We thank Mr Lian-Ping He (Department of Preventive Medicine, Wannan Medical College) for the statistical analysis. This work was supported by National Basic Research Program of China (No. 2010CB945102), National Natural Science Foundation of China (No. 30973197), National Science & Technology Pillar Program of China (No. 2008BAH24B05) and National Infrastructure Program of Chinese Genetic Resources (No. 2006DKA21300).
Mutations in the haemochromatosis gene (HFE) influence iron status in the general population of Northern Europe, and excess iron is associated with the impairment of spermatogenesis. The aim of this study is to inve...
funded by the National Natural Science Foundation of China (31160460);Doctor Fund of Xinjiang Military Groups (2010JC10);National Wool Industry System (nycytx-40-06);National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2011BAD28B05-1-1);863 Plan (2011AA100307);Breeding Strategy of Xinjiang Group (2011BA006)
[Objective]The aim was to explore optimization of system of oocytes in-vitro culture of young animals. [Method]Effects of EGF ( epidermal growth factor) and β-mercaptoethanol in maturation media on fertilization,cl...
supported by the National Basic Research Program of China (2007CB109205,2009CB118804);the National Natural Science Foundation of China (30623001)
Ammonia is toxic to fish in natural and artificial waters.We evaluated the acute(96 h) and chronic(21 d) toxicity of un-ionized ammonia to GH transgenic common carp(Cyprinus carpio L.) and non-transgenic common carp u...
supported by the National Basic Research Program of China (Grant No. 2010CB126302);the Earmarked Fund for Modern Agro-industry Technology Research System for Tilapia;the Agriculture Research Special Funds of 3-49;the National High Technology Research and Development Program of China (Grant No. 2007AA091404) to Dr. Li WenSheng
In teleosts, growth hormone (GH) production is governed by multiple neuroendocrine factors from the hypothalamus and other regulators from the pituitary and peripheral organs. Exploring the principles followed by pitu...
National Basic Research Program of China(973 program,No:2006CB504502);Chinese Na-tional Foundation of Natural Sciences.(No.90209009)
Objective To observe the influence of acupuncture on hypothalamus-pituitary-ovary axis (HPOA) in rats with primary dysmenorrhea, and to explore its mechanisms. Methods Effects of acupuncture on the concentration lev...
Supported by the National Basic Research Program of the Ministry of Science and Technology, People’s Republic of China (Grant No. 2006CB102001);The nucleotide sequence data reported in this article have been submitted to Gen-Bank and have been assigned the accession number AY628763
Prothoracicotropic hormone (PTTH), a neuropeptide hormone stimulating the prothoracic glands to synthesize ecdysone, plays an important role in regulating postembryonic development in insects. The cDNA encoding PTTH w...