This work was conceived by PCK,and was by supported by ARC Project No.CE140100036(Davis),NSF CAREER CBET-1553945(Ding),NIH MIRA R35GM119691(Ding),AFTAM Research Collaboration Award(Davis and Ke),the National Natural Science Foundation of China(No.11904189)(Sun);the Juvenile Diabetes Research Foundation(Purcell and Faridi).A.W.P.is supported by a Principal Research Fellowship from the Australian NHMRC.TEM imaging was performed at Bio21 Advanced Microscopy Facility,University of Melbourne.HIM imaging was performed at the MCFP platform,University of Melbourne by Dr.Anders Barlow.
The amyloid aggregation of peptides and proteins is a hallmark of neurological disorders and type 2 diabetes.Human islet amyloid polypeptide(IAPP),co-secreted with insulin by pancreaticβ-cells,plays dual roles in bot...
the National Natural Science Foundation of China (Nos.51872030,51631001,21643003,51702016,and 51501010);Fundamental Research Funds for the Central Universities and Beijing Institute of Technology Research Fund Program for Young Scholars and ZDKT18-01 fund from State Key Laboratory of Explosion Science and Technology (Beijing Institute of Technology).We acknowledge critical and quantity of testing work supported by Beijing Zhongkebaice Technology Service Co., Ltd.
Utilizing vacuum-tuned-atmosphere induced dip coating method,we achieve the cross-dimensional macroscopic diverse self-assemblies by using one building block with one chemical functionality.Coordinated modulating the ...
supported by ARC Project CE140100036 (Davis), NSF CAREER CBET-1553945 (Ding), NIH MIRA R35GM119691 (Ding) and Monash Institute of Pharmaceutical Sciences (Ke); Purcell is supported by a Principal Research Fellowship from the Australian NHMRC;Pilkington acknowledges an Australian Government Research Training Program (RTP) Scholarship;Javed acknowledges Monash International Postgraduate Research Scholarship
Although much has been learned about the fibrillization kinetics, structure and toxicity of amyloid proteins, the properties of amyloid fibrils beyond the saturation phase are often perceived as chemically and biologi...