IMMUNO

作品数：466被引量：1235H指数：18
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  • 期刊=Cell Researchx
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ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer被引量：3
《Cell Research》2024年第1期58-75,共18页Li-Ping Ge Xi Jin Ding Ma Zi-Yu Wang Cheng-Lin Liu Chao-Zheng Zhou Shen Zhao Tian-Jian Yu Xi-Yu Liu Gen-Hong Di Zhi-Ming Shao Yi-Zhou Jiang 
supported by the National Key R&D Program of China(2020YFA0112304);the National Natural Science Foundation of China(82272822,81922048,82341003,82002799,92159301);the Natural Science Foundation of Shanghai(22ZR1479200,23ZR1411800);the Shanghai Key Laboratory of Breast Cancer(12DZ2260100);the SHDC Municipal Project for Developing Emerging and Frontier Technology in Shanghai Hospitals(SHDC12021103);the Youth Talent Program of Shanghai Health Commission(2022YQ012).
Triple-negative breast cancer(TNBC)is an aggressive disease characterized by remarkable intratumor heterogeneity(ITH),which poses therapeutic challenges.However,the clinical relevance and key determinant of ITH in TNB...
关键词：IMMUNOTHERAPY IMMUNITY inhibited 
Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response被引量：21
《Cell Research》2022年第6期530-542,共13页Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou 
supported by grants from the National Key R&D Program of China(2016YFA0500304);the National Nature Science Foundation of China(NSFC)(81773052,81572806,81802854,81802853);the Guangzhou Science Technology and Innovation Commission(201607020038);the Natural Science Foundation of Guangdong Province(2017A030308007);the Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06S638);the Leading Talents Program of Guangdong Province(2016LJ06S464).
Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect ...
关键词：IMMUNOTHERAPY SPECIFICITY TCR 
Signaling networks in immunometabolism被引量：13
《Cell Research》2020年第4期328-342,共15页Jordy Saravia Jana L.Raynor Nicole M.Chapman Seon Ah Lim Hongbo Chi 
This work was supported by NIH AI105887,AI131703,AI140761,AI150241,AI150514 and CA221290(to H.C).
Adaptive immunity is essential for pathogen and tumor eradication,but may also trigger uncontrolled or pathological inflammation.T cell receptor,co-stimulatory and cytokine signals coordinately dictate specific signal...
关键词：METABOLISM IMMUNITY IMMUNO 
Uncoupling therapeutic from effects for safer and effective CTLA4 humanized mice immunotherapy-related adverse anti-CTLA-4 antibodies in被引量：7
《Cell Research》2018年第4期433-447,共15页Xuexiang Du Mingyue Liu Juanjuan Su Peng Zhang Fei Tang Peiying Ye Martin Devenport Xu Wang Yan Zhang Yang Liu Pan Zheng 
Anti-CTLA-4 monoclonal antibodies （mAbs） confer a cancer immunotherapeutic effect （CITE） but cause severe immunotherapy- related adverse events （irAE）. Targeting CTLA-4 has shown remarkable long-term benefit and...
关键词：免疫疗法 人性化 治疗学 CTLA4 安全 抗体 老鼠 CTLA-4 
Mortalin imaging in normal and cancer cells with quantum dot immuno conjugates被引量：14
《Cell Research》2003年第6期503-507,共5页ZEENIA KAUL TOMOKO YAGUCHI SUNIL C KAUL TAKASHI HIRANO RENU WADHWA KAZUNARI TAIRA 
Quantum dots are the nanoparticles that are recently emerging as an alternative to organic fluorescence probes in cell biology and biomedicine,and have several predictive advantages.These include their i)broad absorpt...
关键词：量子 正常细胞 癌细胞 免疫 
Expression of cytokine mRNA during immuno-modulation of murine suppressor macrophages被引量：1
《Cell Research》1998年第4期317-322,共6页FENGWEIGUO ZHONGLIANGCHANG 
In order to analyze the mechanism of immunomodulation by LPS on murine peritoneal suppressor macrophages, we have, using RNase protection assay,checked the changes of mRNA expression pattern of several cytokine genes ...
关键词：Suppressor macrophage cytokne mRNA expression immuno-modulation 
Enhanced radioimmunotherapeutic efficacy of a monoclonal antibody cocktail against SMMC-7721 human hepatocellular carcinoma被引量：2
《Cell Research》1998年第3期241-247,共7页SONG YI QIANG GEN FENG WANG XIN LAN DAI HONG XIE(Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China) 
The improved tumoricidal effect of the radioatibody mixture ("cocktail") has been reported recently for the treatment of colon tumor. In the present study, we demonstrated the enhanced radioimmunotherapeutic efficacy ...
关键词：Mouse monoclonal antibody human hepatocellular carcinoma RADIOIMMUNOTHERAPY antibody cocktail 
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