云南高校图书馆联盟文献共享服务平台- INSULIN

INSULIN_RESISTANCE: 作品数：784被引量：3615H指数：25; 导出分析报告; 相关作者：李雪飞张思仲刘合焜陈素云田浩明更多>>; 相关机构：南京医科大学北京大学第一医院北京大学四川大学华西医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>

COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors: 《Signal Transduction and Targeted Therapy》2022年第1期270-281,共12页Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei; This study was supported by the joint emergency grants for prevention and control of SARS-CoV-2 of Ministry of Science and Technology of China,Guangdong Science and Technology Department and Guangzhou Municipal Science and Technology Bureau(2020B111108001);Guangdong Science and Technology Department(2020B121206001&2020B1212030004);The funders had no role in study design,data collection and analysis,or preparation of the manuscript.; Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism.In this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-relat...; 关键词：metabolism mechanism resistance

Main alkaloids of Rhizoma Coptidis improved palmitic acidinduced insulin resistance in HepG2 cells via AMPK and MAPK signaling pathway: 《Asian Journal of Traditional Medicines》2020年第5期239-254,共16页Ming Qu Ying Wang Shijie Cao Yalu Liu Da Liu Feng Qiu Ning Kang; supported by Technology Major Project of China“Key New Drug Creation and Manufacturing Program”(No.2017ZX09301012-001);the National Natural Science Foundation of China(No.20972098,No.81703776 and No.81430095);the National Basic Research Program of China(No.2014CB560706).; Rhizoma Coptidis,a traditional Chinese herbal medicine,has been used for treating diabetes for thousands of years.However,the molecular basis for this action has not been elucidated.In the present study,the effects of...; 关键词：Rhizoma Coptidis ALKALOIDS insulin resistance AMPK pathway MAPK pathway GLUT2

Peripheral Artery Disease and Risk of Fibrosis Deterioration in Nonalcoholic Fatty Liver Disease:A Prospective Investigation被引量：2: 《Biomedical and Environmental Sciences》2020年第4期217-226,共10页ZHU Wen DENG Chan Juan XUAN Li Ping DAI Hua Jie ZHAO Zhi Yun WANG Tian Ge LI Mian LU Jie Li XU Yu CHEN Yu Hong WANG Wei Qing BI Yu Fang XU Min; Grants from the Ministry of Science and Technology of China[2018YFC1311705,2016YFC1305600,and 2016YFC1304904];the National Natural Science Foundation of China[81770842,81941017,and 81870604];the Shanghai Science and Technology Commission[YDZX20173100004881];the Shanghai Shen-Kang Hospital Development Center[SHDC12016202]。; Objective Liver fibrosis is an important predictor of mortality in nonalcoholic fatty liver disease(NAFLD).Peripheral artery disease(PAD)and liver fibrosis share many common metabolic dysfunctions.We aimed to explore ...; 关键词：Ankle-brachial index Nonalcoholic fatty liver disease Fibrosis deterioration NAFLD fibrosis score Insulin resistance

Follicular hyperandrogenism and insulin resistance in polycystic ovary syndrome patients with normal circulating testosterone levels被引量：2: 《The Journal of Biomedical Research》2018年第3期208-214,共7页Andi Li Lu Zhang Jiajia Jiang Nan Yang Ying Liu Lingbo Cai Yugui Cui Feiyang Diao Xiao Han Jiayin Liu Yujie Sun; supported by the Key Project of Chinese National Programs for Fundamental Research and Development (973 Program, 2012CBA01306);the National Natural Science Foundation of China (81471429); Polycystic ovary syndrome（PCOS） is a common reproductive disease with high heterogeneity. The role of excess androgen in PCOS etiology remains disputed, since around 20%-50% of PCOS women do not display hyperandroge...; 关键词：polycystic ovary syndrome hyperandrogenism insulin resistance follicular fluid

The relationship between insulin resistance/β-cell dysfunction and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus： the Desheng Diabetic Eye Study被引量：20: 《International Journal of Ophthalmology(English edition)》2018年第3期493-500,共8页Yun-Yun Li Xiu-Fen Yang Hong Gu Torkel Snellingen Xi-Pu Liu Ning-Pu Liu; Supported by the Beijing Natural Science Foundation(No.7131007);National Basic Research Program of China(973 Program;No.2007CB512201); AIM： To investigate the relationship between insulin resistance （IR）/β-cell dysfunction and diabetic retinopathy （DR） in Chinese patients with type 2 diabetes mellitus （T2DM）, and to explore further whether th...; 关键词：type 2 diabetes mellitus diabetic retinopathy insulin resistance β-cell function body mass index

Review on the Effect of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors for the Treatment of Non-Alcoholic Fatty Liver Disease被引量：3: 《Journal of Huazhong University of Science and Technology(Medical Sciences)》2015年第3期333-336,共4页李超林赵璐杰周新丽吴慧潇赵家军; supported in part by grants from the National Basic Research Program of China(No.2012CB524900);Department of Science&Technology of Shandong Province,China(Nos.2012GSF11824 and 2011780); Non-alcoholic fatty liver disease（NAFLD） is a common liver disease and it represents the hepatic manifestation of metabolic syndrome, which includes type 2 diabetes mellitus（T2DM）, dyslipidemia, central obesity an...; 关键词：glucagon-like peptide-1 receptor agonists dipeptidyl peptidase-4 non-alcoholic fatty liverdisease insulin resistance type 2 diabetes mellitus

Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women被引量：16: 《Acta Pharmacologica Sinica》2014年第12期1521-1526,共6页Wei-wei HU Yao-hua KE Jin-wei HE Wen-zhen FU Yu-juan LIU Di CHEN Zhen-lin ZHANG; Acknowledgements This study was supported by the National Natural Science Foundation of China （NSFC）（Grant Nos 81370978, 81070692 and 81170803）, Academic Leaders in Health Sciences in Shang- hai （XBR2011014, 2014CB942903, SHDC12013115, CSTC2013j- cyjC00009）, National Basic Research Program of China （Grant No 2014CB942903 to Zhen-lin ZHANG） and Program for Outstanding Medical Academic Leader （051）.; Aim： Osteocalcin, a biochemical marker of bone formation, has been suggested to be involved in the regulation of energy metabolism. The aim of this study was to investigate the possible association between serum oste...; 关键词：OSTEOCALCIN glucose metabolism BMI insulin resistance Chinese women

Liver Med23 ablation improves glucose and lipid metabolism through modulating FOX01 activity被引量：6: 《Cell Research》2014年第10期1250-1265,共16页Yajing Chu Leonardo Gomez Rosso Ping Huang Zhichao Wang Yichi Xu Xiao Yao Menghan Bao Jun Yan Haiyun Song Gang Wang; We thank Drs Dang-Sheng Li, Yi Liu, Gen-Sheng Feng, and Arnie Berk for critical reading of the manuscript, Drs Li-Jian Hui, Bao-Liang Song, Yong Liu, Yi-Guo Wang, and Zhong-Zhou Yang for discussions, Jing-Wen Yin for knockout design, MARC of Nanjing University for help with generating the Med23flax mice, Xing Fu for technical help and analysis with RNA-Seq. This study was supported in part by grants from the Chinese Academy of Sciences （XDA01010401）, the Ministry of Science and Technology of China （2009CB941100 and 2011CB510104）, and the National Natural Science Foundation of China （81030047 to G W, and 31322039 to H S）.; Mediator complex is a molecular hub integrating signaling, transcription factors, and RNA polymerase II （RNAPII） machinery. Mediator MED23 is involved in adipogenesis and smooth muscle cell differentiation, suggesti...; 关键词：FOXO1 liver Med23-knockout mice GLUCONEOGENESIS insulin resistance OBESITY diabetes

Effects of Traditional Chinese Medicinal Plants on Antiinsulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells被引量：4: 《Natural Products and Bioprospecting》2014年第4期197-206,共10页Jun-Zeng Ma Li-Xin Yang Xiao-Ling Shen Ji-Huan Qin Li-Lan Deng Selena Ahmed Hong-Xi Xu Da-Yuan Xue Jiang-Xia Ye Gang Xu; China National Major Projects(2009ZX09103-436)and 973 Program(2011CB915503)of Science and Technology of P.R.China;the reservation-talent project of Yunnan Province(2009CI073);the foundation of study abroad returnees from Ministry of Personnel for financial support(Ms.Li-Xin Yang);the foundations from CAS(Dr.Gang Xu).; Medicinal plants have a long history of use in China to treat diabetic symptoms.Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the...; 关键词：Traditional medicinal plants Diabetes Anti-insulin resistance bioactivity DXMS-induced insulin resistant HepG2 cells

Potential roles of glucagon-like peptide-1-based therapies in treating non-alcoholic fatty liver disease被引量：13: 《World Journal of Gastroenterology》2014年第27期9090-9097,共8页Ye Liu Rui Wei Tian-Pei Hong; Supported by Chinese National 973 Program No.2012CB517502;the Research Fund for the Doctoral Program of Higher Education of China No.20120001120069; Glucagon-like peptide-1(GLP-1)-based therapies have demonstrated efficacy and safety in treating type 2 diabetes, which shares a similar pathophysiological mechanism with non-alcoholic fatty liver disease(NAFLD). Rece...; 关键词：Non-alcoholic fatty liver disease Glucagon-like peptide-1 Dipeptidyl peptidase-4 Insulin resistance Oxidative stress Lipid metabolism

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