Dr. Chu’s work was supported by the Innovative Award from the American College of Rheumatology Research Foundation and the VA Merit Review grant(No. I01BX005195)。
Schnitzler syndrome is a rare disease of adult-onset with main features including chronic urticarial rash, recurrent fever, arthralgia or arthritis, monoclonal gammopathy of undetermined significance (MGUS), and marke...
To the Editor:Fungal keratitis is primarily caused by pathogenic fungi species,such as Fusarium solani and Aspergillus fumigatus.The incidence of A.fumigatus has been increased worldwide.[1]Although new therapies have...
Background Epidermal burn injury may trigger significant apoptosis of the spleen cells,which might be caused by a burninduced systemic inflammatory reaction.Heparin has been shown to possess anti-inflammatory properti...
Background Bacteremia remains a significant cause of morbidity and mortality after kidney transplantation. This study was conducted to investigate whether the polymorphisms of tumor necrosis factor (TNF)-β, interle...
Background HIV-1 infected and immune-activated macrophages and microglia secrete neurotoxins, such as tumor necrosis factor-a (TNF-a) and interleukin-113 (IL-113), which play major role in the neuronal death. It h...
This study was supported by the grants from the Chinese National Basic Research Program (No. 2005CB522602), Beijing Science & Technology NOVA Program (No. 2006A54) and National Natural Science Foundation of China (No. 31071100).
Background The interleukin-1 (IL-1) receptor-associated kinase 1 (IRAK1) is believed to play an important role in the pathogenesis of sepsis. Recent studies have suggested that the I RAK1 functional genetic varian...
The study was supported by a grant from the National Natural Science Foundation of China (No. 2004NSFC30471741).
Background The most significant biological change in intervertebral disc degeneration is the decrease of chondrocyte specific gene and protein expression of Sox9 and collagen type Ⅱ. Interleukin-1 (IL-1) is not exp...
This research was supported by a grant from National Natural Science Foundation of China (No. 30271195)
Background Solar ultraviolet (UV) irradiation induces the production of matrix metalloproteinases (MMPs) by activating cellular signalling transduction pathways. MMPs are responsible for the degradation and/or inh...
Background Generally speaking, undifferentiated keratinocytes may synthesize a larger amount of IL-α and its production is decreased as cells complete differentiation gradually. Ultraviolet B (UVB) light can signigi...
Objective To determine whether interleukin-1α and 1β gene polymorphism is associated with rheumatoid arthritis disease activity and bone mineral metabolism, and whether there is any relationship between IL-1β an...