supported by STI2030-Major Projects,No.2022ZD0207600(to LZ);the National Natural Science Foundation of China,Nos.32070955(to LZ),U22A20301(to KFS);the Natural Science Foundation of Guangdong Province,No.2021A1515012197(to HO);Guangzhou Core Medical Disciplines Project,No.2021-2023(to HO);Key Research and Development Plan of Ningxia Hui Automomous Region,No.2022BEG01004(to KFS);Science and Technology Program of Guangzhou,China,No.202007030012(to KFS and LZ)。
Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy.Physical exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitatio...
partially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (15K06723;18K07380);the Japan Agency for Medical Research and Development (AMED) (21nk0101538h0002) (to TN)。
Brain injuries like ischemic stroke induce endogenous stem cell production. Although the precise traits of stem cells in pathological brains remain unclear, we previously demonstrated that injury/ischemia-induced stem...
Hainan Province Natural Science Foundation Youth Project“Research on the Mechanism of miR-124-3p Regulation of Cerebral Ischemia-Reperfusion Through the PI3K/Akt/mTOR Pathway”(Project No.820QN391)。
Objective: To investigate the role of miR-124-3p in ischemia-reperfusion injury following ischemic stroke and to evaluate the neuroprotective effects of miR-124-3p inhibition on neurological outcomes, infarct size, an...
Bioisosteres play an important role in pharmaceutical and agricultural compound design that has been developed to enhance the properties of molecules.As a sp3-rich small ring cage hydrocarbons,bicyclo[1.1.1]pentanes(B...
supported by the national key research and development program of China(2019YFC1708900);National Natural Science Foundation of China(82204973);scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2021B015);the fundamental research funds for the central public welfare research institutes of Institute of Chinese Materia Medica,China Academy ofChinese Medical Sciences(ZXKT21030);special program for outstanding,young scientific and technological talents(innovation)of China Academy of ChineseMedical Sciences(ZZ15-YQ-034).
Background:Heart failure(HF)is the leading cause of death worldwide.Myocardial infarction(MI)is a major contributor to HF.Shengmai injection(SMI)has exhibited protective efficacy in preventing HF.However,the advantage...
The development and utilization of low-grade polymetallic deposits with strategic mineral resources is one of the important measures to alleviate the current high dependence on strategic mineral resources in China. Ho...
The biliary tract, portal vein, and systemic circulation are the anatomical linkages that enable bidirectional inter-organ communications through the gut–liver axis.(Han et al. 2023). Under physiological conditions, ...