Objective To investigate the effect and mechanism of forkhead box K1 (FOXK1) in acute kidney injury(AKI),and to provide new ideas and targets for preventing and treating AKI.Methods Three models of AKI were establishe...
supported by a Foundation Project:National Natural Science Foundation of China(Nos.82100417,81760094),China;The Foundation of Jiangxi Provincial Department of Science and Technology Project(Nos.20202ACBL206001,20212BAB206022,20181BAB205026).
Background:Biochanin A is an excellent dietary isoflavone that has the concomitant function of both medicine and foodstuff.The attenuation function of biochanin A on blood-brain barrier(BBB)damage induced by cerebral ...
Objective To investigate the role of immunoglobulinlike domain-containing receptor 2(Ildr2)in renal fibrosis induced by ischemia-reperfusion.Methods Ildr2 knockout mice(KO group)were constructed using CRISPR/Cas9 tech...
Objective: Exposure of the heart to repeated, brief episodes of coronary occlusion/reperfusion prevents lethal myocyte injury. Necrosis and apoptosis, two seemingly distinct mechanisms of cell death caused by ischemia...
Ovarian torsion is one of the gynecological emergencies that affect ovarian tissue integrity and fertility. In this study, we aim to investigate the effects of Momordica charantia (MC) on ovarian tissue injur...
Aim Shengmai injection (SMI) , a Chinese patent medicine deprived from an ancient Chinese herbal compound Shengmai san, which is used extensively for the treatment of cardiovascular and cerebrovascular disease in cl...
supported by the fund from the State Administration of Traditional Chinese Medicine (No.04-05JP61)
Objective:To study the effect of Chinese herbal medicine Kangxin Fumai Granule(康心复脉颗粒 Granule for heart diseases) serum on the primary cultured sinoatrial node(SAN) cell apoptosis induced by simulated ischemia-r...
Aim: To examine whether isoliquiritigenin (ISL) can attenuate myocardial ischemiareperfusion (MI/R) injury in rats by inducing metallothionein (MT) through activation of janus kinase 2 (JAK 2)/signal transduc...
Supported by the National Natural Science Foundation of China,No. 30400172, 30230370the National Basic Science and Development programme (973 programme, 2005 CB 522603)
AIM: To detect the effect of acid fibroblast growth factor (aFGF) on P53 and P21WAF-1 expression in rat intestine after ischemia-reperfusion (I-R) injury in order to explore the protective mechanisms of aFGF. MET...
Supported by National Natural Science Foundation of China (No.30070314)
Objective: To study the effect of simulated ischemia-reperfusion (I/R) on If of sinoatrial node (SAN) cells and the intervention of KATP channel opener Pinacidil. Methods: The SAN cells of the neonatal rats were detac...