ISCHEMIC

作品数：602被引量：1968H指数：20
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相关领域：医药卫生更多>>
相关作者：王文孙芳玲张丽艾厚喜蒋莹更多>>
相关机构：首都医科大学北京大学上海交通大学附属第六人民医院青岛大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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The potential mechanism and clinical application value of remote ischemic conditioning in stroke被引量：1
《Neural Regeneration Research》2025年第6期1613-1627,共15页Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo 
supported partly by the National Natural Science Foundation of China,No.82071332;the Chongqing Natural Science Foundation Joint Fund for Innovation and Development,No.CSTB2023NSCQ-LZX0041 (both to ZG)。
Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may...
关键词：Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke NEUROINFLAMMATION neuroprotection Notch1 PI3K remote ischemic conditioning STROKE 
Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells
《Neural Regeneration Research》2024年第11期2341-2342,共2页Masato Kanazawa Itaru Ninomiya Yutaka Otsu Masahiro Hatakeyama 
supported by the JSPS KAKENHI Grant-in-Aid for Scientific Research(Grant number:21K19441,22H03183)(to MK);Early-Career Scientists(Grant number:21K15185)(to IN)and(Grant number:20K16485)(to MH).
Stroke is the second leading cause of death and the third leading cause of disability worldwide after heart disease.Researchers predict that stroke deaths and permanent disabilities will increase worldwide by the year...
关键词：ISCHEMIC DEATH CEREBRAL 
Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients被引量：2
《Acta Pharmacologica Sinica》2024年第5期914-925,共12页Zhu-wei Miao Nuo Wang Wen-jun Hu Si-li Zheng Dong-sheng Wang Fu-qiang Chang Zhi Wang Jia-sheng Tian Xiao-hui Dong Tao Wu Chao-yu Miao 
supported by the National Natural Science Foundation of China Major Project(82030110,82330117 and 81730098 to CYM).
Metrnl is a secreted protein involved in neurite outgrowth,insulin sensitivity,immunoinflammatory responses,blood lipids and endothelial protection.In this study,we investigated the role of Metrnl in ischemic stroke.F...
关键词：ischemic stroke Metrnl secreted protein vascular pathogenesis ATHEROSCLEROSIS THROMBUS 
Stem cell-based ischemic stroke therapy:Novel modifications and clinical challenges被引量：1
《Asian Journal of Pharmaceutical Sciences》2024年第1期18-34,共17页Yuankai Sun Xinchi Jiang Jianqing Gao 
supported by the National Natural Science Foundation of China(U22A20383,82003668);the Natural Science Foundation of Zhejiang Province(LD22H300002,LQ21H300002);Ningbo Technology Innovation 2025 Major Special Project(2022Z150).
Ischemic stroke(IS)causes severe disability and high mortality worldwide.Stem cell(SC)therapy exhibits unique therapeutic potential for IS that differs from current treatments.SC’s cell homing,differentiation and par...
关键词：Ischemic stroke Stem cell therapy Stem cell modification Cell therapy challenge 
Targeting TRPM2- and TRPM4-extrasynaptic N-methyl-D-aspartate receptor coupling in ischemic stroke被引量：1
《Neural Regeneration Research》2023年第11期2383-2384,共2页Pengyu Zong Cindy X.Li Jianlin Feng Lixia Yue 
National Institute of Health (R01-HL143750);American Heart Association (19TPA34890022) to LY。
Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients.However,there is no effective adjunct me...
关键词：ASPARTATE ISCHEMIC MEDICATION 
Impact of Cold Spells on Ischemic Stroke Severity and Clinical Outcomes in Tianjin, China被引量：1
《Journal of Meteorological Research》2023年第4期564-572,共9页Juanjuan XUE Chanjuan WEI Xiaoshuang XIA Xuemei QI Yumeng GU Zhongyan WANG Suqin HAN Lin WANG Xin LI 
Supported by the Research and Popularization of Appropriate Intervention Technology for the Stroke High Risk Group in China(2020R0005);Clinical Medical Research Project of the Second Hospital of Tianjin Medical University (2020LC04);Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-065B)。
There are several studies on the impact of extreme weather on the incidence and mortality of stroke, but the research on the effect of extreme weather events on severity and outcome of ischemic stroke is scarce. This ...
关键词：cold spell meteorological data ischemic stroke SEVERITY treatment outcome 
A New Potential Strategy for Treatment of Ischemic Stroke:Targeting TRPM2–NMDAR Association被引量：2
《Neuroscience Bulletin》2023年第4期703-706,共4页Jiayun Xu Wei Zhang Jianhong Dong Liying Cao Zhihui Huang 
supported by grants from the Research Start-up Project by Hangzhou Normal University(4125C5021920435 and 4125C5021920453).
Ischemic stroke accounts for~85%of all strokes and generally occurs when blood flow is severely reduced due to clots or masses blocking blood vessels and cutting off blood flow to brain cells.The death or damage to ne...
关键词：ISCHEMIC PARALYSIS damage 
Carrier-free programmed spherical nucleic acid for effective ischemic stroke therapy via self-delivery antisense oligonucleotide被引量：1
《Nano Research》2023年第1期735-745,共11页Wenyan Yu Cuiping Xuan Bingbing Liu Lei Zhou Na Yin Enpeng Gong Zhenzhong Zhang Yinchao Li Kaixiang Zhang Jinjin Shi 
This work was funded by the National Natural Science Foundation of China(Nos.82073395 and 319009919);Postdoctoral Science Foundation of China(Nos.2020TQ0288).
Antisense oligonucleotide(ASO)for anti-apoptosis is emerging as a highly promising therapeutic agents for ischemic stroke with complex pathological environment.However,its therapeutic efficacy is seriously limited by ...
关键词：antisense oligonucleotide caspase-3 blood-brain barrier(BBB)penetration ANTI-APOPTOSIS ischemic stroke 
Cell-free mitochondrial DNA quantification in ischemic stroke patients for non-invasive and real-time monitoring of disease status被引量：1
《World Journal of Translational Medicine》2022年第2期14-28,共15页Nusrath Fathima Sandhya Manorenj Sandeep Kumar Vishwakarma Aleem Ahmed Khan 
BACKGROUND Acute ischemic stroke(AIS)is one of the major causes of the continuous increasing rate of global mortality due to the lack of timely diagnosis,prognosis,and management.This study provides a primitive platfo...
关键词：Cell-free mitochondrial DNA NADH-ubiquinone oxidoreductase chain 1 Ischemic stroke Circulating biomarker National Institute of Health Stroke Scale score Stroke assessment Severity and outcome 
Regulatory T cells in ischemic stroke被引量：6
《Acta Pharmacologica Sinica》2022年第1期1-9,共9页Hong-yun Wang Jun-rui Ye Li-yuan Cui Shi-feng Chu Nai-hong Chen 
This work was supported by the National Natural Science Foundation of China(81730096,82074044,81873026,81973499,and 81773924);the Natural Science Foundation of Beijing(7192135);the Drug Innovation Major Project(2018ZX09711001-002-007,2018ZX09711001-003-005,and 2018ZX09711001-009-013);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2 M-1-004).
Recent evidence shows that when ischemic stroke(IS)occurs,the BBB would be destructed,thereby promoting the immune cells to migrate into the brain,suggesting that the immune responses can play a vital role in the path...
关键词：regulatory T cells ischemic stroke INFLAMMATION CROSSTALK stroke-induced immunodepression ischemic stroke therapy 
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