Supported by the Natural Science Foundation of Gansu Province,No.21JR7RA373 and No.24JRRA295.
BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal prognosis.Immunotherapy has become an important treatment strategy for HCC,as immunity is closely related to inflammation in th...
Supported by the National Natural Science Foundation of China,No.82160842;Clinical Research Project of Research Fund of Gansu Provincial Hospital,No.23GSSYD-17.
Gastrointestinal stromal tumors(GIST)are the most common mesenchymalderived tumors of the GI tract.They can occur throughout the GI tract,and the survival time of some patients can be improved by first-line targeted t...
supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CAMS,2021-I2M1-072,China);National Natural Science Foundation of China (82161138027 and 81970358)。
Acute pancreatitis(AP)is a devastating disease characterized by an inflammatory disorder of the pancreas.P-selectin glycoprotein ligand-1(PSGL-1)plays a crucial role in the initial steps of the adhesive at process to ...
Immuno-oncology represents a groundbreaking and well-established field within cancer treatment.Among the various immuno-oncology targets,the exploration of programmed cell death-1/ligand-1 for drug discovery has prove...
the National Natural Science Foundation of China(Nos.31971304,32271420,and 21977024);the Beijing-Tianjin-Hebei Basic Research Cooperation Project(No.19JCZDJC64100);Cross-disciplinary Project of Hebei University(No.DXK201916);One Hundred Talent Project of Hebei Province(No.E2018100002);Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province(No.B2021201038);Guangdong Basic and Applied Basic Research Foundation(No.2021B1515120065).
The blocking of the immune checkpoint pathway with antibodies,especially targeting to programmed death-1/programmed death ligand-1(PD-1/PD-L1)pathway,was currently a widely used treatment strategy in clinical practice...
supported by the National Natural Science Foundation of China(82003697 and 21977081);the Zhejiang Provincial Natural Science of Foundation of China(LZ19H180001);Wenzhou Medical University(KYYW201901,China);Wenzhou Science and Technology Plan Project(Grant No.Y2020827,China);Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province(Grant No:2018E10008,China).
As a promising modality for cancer therapy, photodynamic therapy(PDT) still acquired limited success in clinical nowadays due to the extremely serious hypoxia and immunosuppression tumor microenvironment. To ameliorat...
Key International Cooperation of the National Natural Science Foundation of China(No. 81920108029);Key Foundation for Social Development Project of the Jiangsu Province, China(No. BE2021741)
Background:Cancer immunotherapy has emerged as a promising strategy against triple-negative breast cancer(TNBC).One of the immunosuppressive pathways involves programmed cell death-1(PD-1)and programmed cell death lig...
Bile duct tumors are comprised of tumors that originate from both intrahepatic and extrahepatic bile ducts and gallbladder tumors.These are aggressive tumors and chemotherapy is still the main treatment for advanced-s...