LIGA

作品数:171被引量:438H指数:11
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相关领域:电子电信医药卫生更多>>
相关作者:伊福廷田扬超陈迪朱荻彭良强更多>>
相关机构:上海交通大学中国科学技术大学中国科学院清华大学更多>>
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相关基金:国家自然科学基金国家高技术研究发展计划国家攀登计划广东省自然科学基金更多>>
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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma
《World Journal of Gastrointestinal Oncology》2025年第1期176-198,共23页Zhong-Xia Yang Li-Ting Zhang Xiao-Jun Liu Xue-Bin Peng Xiao-Rong Mao 
Supported by the Natural Science Foundation of Gansu Province,No.21JR7RA373 and No.24JRRA295.
BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal prognosis.Immunotherapy has become an important treatment strategy for HCC,as immunity is closely related to inflammation in th...
关键词:INTERLEUKIN-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma IMMUNOTHERAPY 
Advances in immunotherapy of M2 macrophages and gastrointestinal stromal tumor
《World Journal of Gastrointestinal Oncology》2024年第7期2915-2924,共10页Xiao-Ke Wang Xin Yang Tong-Han Yao Peng-Xian Tao Guan-Jun Jia De-Xian Sun Lin Yi Yuan-Hui Gu 
Supported by the National Natural Science Foundation of China,No.82160842;Clinical Research Project of Research Fund of Gansu Provincial Hospital,No.23GSSYD-17.
Gastrointestinal stromal tumors(GIST)are the most common mesenchymalderived tumors of the GI tract.They can occur throughout the GI tract,and the survival time of some patients can be improved by first-line targeted t...
关键词:Gastrointestinal stromal tumor M2 macrophage Inflammatory response Programmed death receptor-1 Programmed death ligand-1 IMATINIB IMMUNOTHERAPY Targeted therapy 
A non-human primate derived anti-P-selectin glycoprotein ligand-1 antibody curtails acute pancreatitis by alleviating the inflammatory responses
《Acta Pharmaceutica Sinica B》2023年第11期4461-4476,共16页Yuhan Li Xiangqing Ding Xianxian Wu Longfei Ding Yuhui Yang Xiaoliang Jiang Xing Liu Xu Zhang Jianrong Su Jianqing Xu Zhiwei Yang 
supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CAMS,2021-I2M1-072,China);National Natural Science Foundation of China (82161138027 and 81970358)。
Acute pancreatitis(AP)is a devastating disease characterized by an inflammatory disorder of the pancreas.P-selectin glycoprotein ligand-1(PSGL-1)plays a crucial role in the initial steps of the adhesive at process to ...
关键词:Acute pancreatitis PSGL-1 Non-human primate Monoclonal antibody Therapeutic antibody RH001-6 Adhesion of leukocytes to endothelial cells Inflammatory responses Pancreatic injury 
Advances on biological evaluation methods of programmed cell death protein-1/ligand-1 inhibitors
《Precision Medicine Research》2023年第2期51-55,共5页Qi Miao Wan-Heng Zhang 
Immuno-oncology represents a groundbreaking and well-established field within cancer treatment.Among the various immuno-oncology targets,the exploration of programmed cell death-1/ligand-1 for drug discovery has prove...
关键词:programmed cell death-1/ligand-1 inhibitors BIOASSAYS drug candidate evaluation 
Liposome-coated CaO_(2)nanoblockers for enhanced checkpoint blockade therapy by inhibiting PD-L1 de novo biosynthesis
《Nano Research》2023年第5期7227-7236,共10页Ruijun Che Dandan Han Fei Wang Huifang Liu Miao Fan Hongyu Yan Tingshan Xiao Zhaoshuo Wang Xiaohan Zhou Xueyi Wang Kaihan Zhang Caiwen Ou Jinchao Zhang Zhenhua Li 
the National Natural Science Foundation of China(Nos.31971304,32271420,and 21977024);the Beijing-Tianjin-Hebei Basic Research Cooperation Project(No.19JCZDJC64100);Cross-disciplinary Project of Hebei University(No.DXK201916);One Hundred Talent Project of Hebei Province(No.E2018100002);Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province(No.B2021201038);Guangdong Basic and Applied Basic Research Foundation(No.2021B1515120065).
The blocking of the immune checkpoint pathway with antibodies,especially targeting to programmed death-1/programmed death ligand-1(PD-1/PD-L1)pathway,was currently a widely used treatment strategy in clinical practice...
关键词:immune checkpoint blockade therapy oxygen-producing hypoxia-inducible factor-1α(HIF-1α) programmed death ligand-1(PD-L1)redistribution immunogenic cell death 
基于中尺度数据的风电场风速与发电量实时预测被引量:1
《船舶工程》2022年第S02期133-137,143,共6页王东霞 董晔弘 胡号朋 家敏 吴骄 林子菁 
文章从中尺度气象数据分析入手,对海上和陆上风电场发电量的预测进行分析研究,具体阐述了该方法对风电场的限定条件,通过分析中尺度数据,建立风电场各个时刻的风速预测模型,并将风速转化为功率,对风电场各个时刻的风功率进行预测,并根...
关键词:15 km分辨率中尺度气象数据 1 h间隔 风速预测 发电量预测 LIGA 
Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy被引量:2
《Acta Pharmaceutica Sinica B》2022年第11期4204-4223,共20页Zaigang Zhou Jiashe Chen Yu Liu Chunjuan Zheng Wenjuan Luo Lele Chen Shen Zhou Zhiming Li Jianliang Shen 
supported by the National Natural Science Foundation of China(82003697 and 21977081);the Zhejiang Provincial Natural Science of Foundation of China(LZ19H180001);Wenzhou Medical University(KYYW201901,China);Wenzhou Science and Technology Plan Project(Grant No.Y2020827,China);Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province(Grant No:2018E10008,China).
As a promising modality for cancer therapy, photodynamic therapy(PDT) still acquired limited success in clinical nowadays due to the extremely serious hypoxia and immunosuppression tumor microenvironment. To ameliorat...
关键词:Photodynamic immunotherapy SORAFENIB Hypoxia Tumor vessel normalization Mitochondrial oxidative phosphorylation Programmed death ligand-1 
Inhibition of MYC suppresses programmed cell death ligand-1 expression and enhances immunotherapy in triple-negative breast cancer被引量:3
《Chinese Medical Journal》2022年第20期2436-2445,共10页Xintong Li Lin Tang Qin Chen Xumin Cheng Yiqiu Liu Cenzhu Wang Chengjun Zhu Kun Xu Fangyan Gao Jinyi Huang Runtian Wang Xiaoxiang Guan 
Key International Cooperation of the National Natural Science Foundation of China(No. 81920108029);Key Foundation for Social Development Project of the Jiangsu Province, China(No. BE2021741)
Background:Cancer immunotherapy has emerged as a promising strategy against triple-negative breast cancer(TNBC).One of the immunosuppressive pathways involves programmed cell death-1(PD-1)and programmed cell death lig...
关键词:Triple negative breast neoplasms MYC Programmed cell death ligand 1 PD-L1 CDK7 THZ1 IMMUNOTHERAPY 
Estrellas chinas en la Liga de Verano de la NBA
《今日中国(西文版)》2022年第9期72-73,共2页ZHANG XINYANG 
Immunotherapy in biliary tract cancers:Current evidence and future perspectives
《World Journal of Gastrointestinal Oncology》2022年第8期1446-1455,共10页Pedro Luiz Serrano Uson Junior Raphael LC Araujo 
Bile duct tumors are comprised of tumors that originate from both intrahepatic and extrahepatic bile ducts and gallbladder tumors.These are aggressive tumors and chemotherapy is still the main treatment for advanced-s...
关键词:Biliary tract cancer CHOLANGIOCARCINOMA Anti-programmed cell death protein-1 Anti-programmed death ligand-1 Microsatellite instability high Tumor mutational burden high 
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