the Doctorial Innovation Projects of Jiangsu Province(Grant No.KYCX17_1816 to XYJ);the Natural Sciences and Engineering Research Council of Canada(RGPIN-2017-04768 to TQP);the Heart&Stroke Foundation of Canada(G-17-0018361 to TQP);the Lawson Internal Research Fund,and Projects of International Cooperation from Jiangsu(BX2019100);International Cooperation and Exchange from Zhenjiang(GJ2020010).
Calpains have been implicated in heart diseases.While calpain-1 has been detrimental to the heart,the role of calpain-2 in cardiac pathology remains controversial.In this study we investigated whether sustained over-e...
the National Natural Science Foundation of China,No.81560105;the Department of Science and Technology of Guizhou Province,No.LH(2014)7074。
BACKGROUND Calpain-2 is a Ca^2+-dependent cysteine protease,and high calpain-2 activity can enhance apoptosis mediated by multiple triggers.AIM To investigate whether calpain-2 can modulate aberrant endoplasmic reticu...