This research is sponsored by the National Natural Science Foundation of China(81925034,91753117,81721004 to JZ and 81901423 to YYC);Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-01-E00036 to JZ);Shanghai Science and Technology Innovation(19431901600 to JZ);Shanghai Health and Family Planning System Excellent Subject Leader and Excellent Young Medical Talents Training Program(2018BR12 to JZ);Shanghai Health and Family Planning Commission(20184Y0268 to YYC).
Sirtuin 6(SIRT6),a member of the sirtuin family,is a nicotinamide adenine dinucleotide(NAD+)-dependent deacetylase that is involved in various physiological and pathological processes.SIRT6 is generally downregulated ...