MECP2

作品数：158被引量：244H指数：7
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Functional Recovery with Electro-Acupuncture Stimulation in an Mecp2-Knockout Rat Model of Rett Syndrome
《Engineering》2022年第5期83-89,共7页Yanhong Sun Zhifang Chen Yi Xu Yuefang Zhang Zhilei Ge Chenglie Lin Yi Zhou Fangfei Zhao Meiling Yan Xinyi Liu Ying Zhu Jimin Gao Hongyi Li Lihua Wang Jun Hu Zilong Qiu Chunhai Fan 
supported by the Ministry of Science and Technology of China (2016YFA0400902);the National Science Foundation of China (11575278, 21675167, 81690263, 21227804, 21505148, and U1632125);the Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University (GZK1201813);the Key Research Program of Frontier Sciences (QYZDJ-SSW-SLH031);the Open Large Infrastructure Research of Chinese Academy of Sciences (CAS) and Youth Innovation Promotion Association, CAS (2012205 and 2016236)
Rett syndrome is a progressive neurodevelopmental disorder that lacks effective treatments.Although deep-brain stimulation can alleviate some symptoms in Rett model mice,this interventional manipula-tion requires deli...
关键词：Neurodevelopmental disorder Electro-acupuncture stimulation Rett syndrome Motor function Social interaction 
Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice被引量：3
《Science Bulletin》2020年第14期1192-1202,M0004,共12页Le Sun Ruiguo Chen Long Li Bo Yuan Kun Song Na Pan Tian-Lin Cheng Shiyang Chang Kunzhang Lin Xiaobin He Qian Wu Fuqiang Xu Zilong Qiu Xiaoqun Wang 
This work was supported by the National Basic Research Program of China(2017YFA0103303);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010100,XDB02050400,XDB02050005,XDA16020601);National Basic Research Program of China(2017YFA0102601,2019YFA0110100);National Natural Science Foundation of China(NSFC)(91732301,31671072,31771140,81891001,91432111,81527901,31400977,31625013);Grants of Beijing Brain Initiative of Beijing Municipal Science&Technology Commission(Z181100001518004).
Duplications of MECP2-containing genomic segments led to severe autistic symptoms in male. Transgenic mice overexpressing the human MECP2 gene exhibit autistic-like behaviors. Neural circuits underlying social defects...
关键词：MECP2 CRISPR/Cas9 In vivo calcium imaging Social activity AUTISM 
Rett syndrome-causing mutations compromise MeCP2- mediated liquid—liquid phase separation of chromatin被引量：5
《Cell Research》2020年第5期393-407,共15页Liang Wang Mingli Hu Mei-Qing Zuo Jicheng Zhao Di Wu Li Huang Yongxin Wen Yunfan Li Ping Chen Xinhua Bao Meng-Qiu Dong Guohong Li Pilong Li 
This work was supported by grants from the Ministry of Science and Technology of China(2017YFA0504202 to G.L.,2019YFA0508403 to P.L,2018YFE0203302 to P.C.);the National Natural Science Foundation of China(31525013,31630041 and 31521002 to G.L.,31871443 to P.L.,31871290 to P.C.);The work was also supported by the Chinese Academy of Sciences(CAS)Strategic Priority Research Program(XDB19040202);the CAS Key Research Program on Frontier Science(QYZDY-SSW-SMC020);an HHMI International Research Scholar grant(55008737)to G.L.
Rett syndrome(RTT),a severe postnatal neurodevelopmental disorder,is caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2(MeCP2).MeCP2 is a chromatin organizer regulating gene expression.RTT-...
关键词：MECP2 separation LIQUID 
调控MeCP2基因表达的miR-181a在海洛因成瘾及复吸中的作用
《中国药理学与毒理学杂志》2018年第9期732-733,共2页徐文锦 刘婧 庄丁丁 朱华强 赖苗军 周文华 刘惠芬 
浙江省自然科学基金(LY18H090008);国家自然科学基金(81671321);国家重点研发计划(2017YFC1310400);国家重点基础研究发展计划(2015CB553504);宁波市科技计划(2017A610217;2017A04;2018A610291).
目的探索海洛因自身给药大鼠伏隔核miR-181a在海洛因成瘾和复吸中的表观遗传学作用。方法清洁级成年SD雄性大鼠采用固定比率程序1(FR1)进行海洛因自身给药训练(0.05 mg·kg-1注射,14 d,4 h·d-1),成功建立稳定的大鼠海洛因自身给药模型...
关键词：海洛因 成瘾 复吸 表观遗传学 miRNA 
MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated ceil cycle gene translation
《Journal of Molecular Cell Biology》2018年第6期515-526,共12页Wei Zhang Guihai Feng Libin Wang Fei Teng Liu Wang Wei Li Ying Zhang Qi Zhou 
the National Natural Science Foundation of China (31471395 to Q.Z.);the Key Research Projects of the Frontier Science of the Chinese Academy of Sciences (QYZDY- SSW-SMCO02);the National Basic Research Program of China (2014CB964903).
The generation of induced pturipotent stem cells (iPSCs)offers a great opportunity in research and regenerative medicine.The current poor efficiency and incomplete mechanistic understanding of the reprogramming proces...
关键词：MECP2 CELL reprogramming IGFI/AKT/mTOR SIGNALING RIBOSOMAL protein CELL cycle 
MeCP2转基因食蟹猴所表征的类自闭症行为及种系传递被引量：1
《科技导报》2018年第7期48-55,共8页仇子龙 李霄 
国家重点基础研究发展计划(973计划)项目(XDB02050400);国家自然科学基金项目(91432111,91232712,81527901)
自闭症是近年来公众关注度很高的一种神经系统疾病,甲基化CpG结合蛋白2（MeCP2）因其能够在转录水平调节基因表达和操控微小RNA（miRNA）的效应而在自闭症中扮演着重要的角色。当MeCP2因突变而功能缺失时会导致瑞特综合症（Rett syndrom...
关键词：自闭症 MeCP2转基因 社交行为异常 种系传递 
Comprehensive Evaluation on Effect of IMPX977 on Expression of Methyl-CpG-binding Protein 2 in Rats被引量：1
《Chinese Herbal Medicines》2017年第3期275-281,共7页Ya Hu Liang Le Li-xin Qi Ying Zhao Hui Fu Chen Duan Xiao-ying Wang Ke-ping Hu 
CAMS Innovation Fund for Medical Sciences(CIFMS 2016-12M-1-002);973 Program(No.2013CB531200);National Natural Science Foundation of China(No.81271255)
Objective To investigate the effect of IMPX977 on methyl-Cp G-binding protein 2（MeCP2） expression in rats. Methods Forty-eight SD rats were randomly divided into four groups： normal control group, olive oil（negati...
关键词：CEREBELLUM HOMEOSTASIS IMPX977 MECP2 Rett syndrome 
MeCP2与神经发育性疾病被引量：1
《生命科学》2012年第4期374-379,共6页何艳琴 公晓红 张宏丽 王红艳 杨章民 
国家自然科学基金项目(30900404);国家重点基础研究发展计划("973"项目)(2009CB522007)
作为一种转录抑制因子,甲基化CpG结合蛋白2(MeCP2)含有结合甲基化DNA和转录抑制两个特征性的结构域,具有调节转录激活、调节染色体构象、参与RNA剪切等多种功能,在神经发育过程中起着重要的作用。近来的研究表明,MeCP2基因突变与Rett综...
关键词：甲基化CpG结合蛋白2 RTT 孤独症 药物成瘾 
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