云南高校图书馆联盟文献共享服务平台- MECP2

MECP2: 作品数：158被引量：244H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：潘虹包新华吴希如张玉稚李俊更多>>; 相关机构：北京大学第一医院中国科学院大学复旦大学安徽医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划浙江省自然科学基金国家教育部博士点基金更多>>

Extension of the Lifespan of a Mouse Model of Rett Syndrome by Intracerebroventricular Delivery of MECP2: 《Neuroscience Bulletin》2023年第2期297-302,共6页Kan Yang Cheng Cheng Yiting Yuan Yuefang Zhang Shifang Shan Zilong Qiu; supported by grants from the Youth Innovation Promotion Association Chinese Academy of Sciences(2022269);the Youth Science Fund of State Key Laboratory of Neuroscience(SKLN-2022B006);the National Natural Science Foundation of China(82001211,81941015,82021001);the CPSF-CAS Joint Foundation for Excellent Postdoctoral Fellows(2017LH036);the China Postdoctoral Science Foundation(2017M620173);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDBS01060200);the Program of Shanghai Academic Research Leader,the Open Large Infrastructure Research of Chinese Academy of Sciences,the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the Guangdong Key Scientific and Technological Project(2018B030335001).; DearEditors,Rett Syndrome(RTT)is a severe neurodevelopmental disorder characterized by neural dysfunctions and a reduced lifespan,mainly in female patients,involving loss-of-function mutations in the methyl-CpG bindin...; 关键词：MECP2 EXTENSION NEURAL

Abnormal Prefrontal Neural Oscillations are Associated with Social Deficits in MECP2 Duplication Syndrome: 《Neuroscience Bulletin》2022年第12期1598-1602,共5页Xiao Li Yingnan Nie Qiyu Niu Xuanjun Guo Zilong Qiu Shouyan Wang; This work was supported by the National Key R&D Program of China(2018YFC1705800);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);Shanghai Municipal Science and Technology Major Projects(2021SHZDZX0103 and 2017SHZDZX01)。; DearEditor,Methyl-CpG-binding protein 2(MeCP2)participates in regulating the expression of the CREB,TDP-43 and Dnmtl genes[1,2].Recent studies have shown that MeCP2 is essential for maintaining normal neural functions...; 关键词：MECP2 MECP2 patients

Astrocytic Gap Junctions Contribute to Aberrant Neuronal Synchronization in a Mouse Model of MeCP2 Duplication Syndrome: 《Neuroscience Bulletin》2022年第6期591-606,共16页Shengnan Xia Hua-Tai Xu; supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010100);a National Natural Science Foundation of China project(31671113);a Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);and the State Key Laboratory of Neuroscience.; Abnormal synchronous neuronal activity has been widely detected by brain imaging of autistic patients,but its underlying neural mechanism remains unclear.Compared with wild-type mice,our in vivo two-photon imaging sho...; 关键词：Autism spectrum disorder ASTROCYTE Gap junction Neuronal synchrony MeCP2-Slow inward current Neuronal development

Loss of O-GlcNAcylation on MeCP2 at Threonine 203 Leads to Neurodevelopmental Disorders: 《Neuroscience Bulletin》2022年第2期113-134,共22页Juanxian Cheng Zhe Zhao Liping Chen Ying Li Ruijing Du Yan Wu Qian Zhu Ming Fan Xiaotao Duan Haitao Wu; supported by the National Natural Science Foundation of China(31770929 and 31522029);the Beijing Municipal Science and Technology Commission(Z181100001518001 and Z161100000216154)of China.; Mutations of the X-linked methyl-CpG-binding protein 2(MECP2)gene in humans are responsible for most cases of Rett syndrome(RTT),an X-linked progressive neurological disorder.While genome-wide screens in clinical tria...; 关键词：MECP2 O-GlcNAcylation-Dendrite development Synaptic transmission Braiderived neurotrophic factor

Overexpression of MECP2 in the Suprachiasmatic Nucleus Alters Circadian Rhythm and Induces Abnormal Social Behaviors: 《Neuroscience Bulletin》2021年第12期1713-1717,共5页Hailin Liu Zilong Qiu; the National Natural Science Foundation of China(31625013,81941015.and 82021001);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDBS01060200);the Program of Shanghai Academic Research Leader,the Open Large Infrastructure Research of Chinese Academy of Sciences,and the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the Guangdong Key Scientific and Technological Project(2018B030335001).; Dear Editors,Autism spectrum disorder is a highly heritable neurodevel-opmental disorder and is often associated with sleep disorders and dysregulation of the circadian rhythm[1,2].Whether neural circuits governing th...; 关键词：MECP2 RHYTHM CONNECTED

Gene Editing to the Rescue:Reversal of Social Deficits Associated with MECP2 Duplication被引量：1: 《Neuroscience Bulletin》2020年第6期567-569,共3页Zi-Xian Yu Dan-Yang Wang Xiao-Hong Xu; Methyl-CpG-binding protein 2 (MeCP2) is broadly recognized as the genetic cause of Rett Syndrome (RTT),a devastating neurodevelopmental disorder with the progressive loss in motor skills and speech that is found almos...; 关键词：MECP2 MECP2 RESCUE

Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex被引量：5: 《Neuroscience Bulletin》2020年第6期570-584,共15页Bin Yu Bo Yuan Jian-Kun Dai Tian-lin Cheng Sheng-Nan Xia Ling-Jie He Yi-Ting Yuan Yue-Fang Zhang Hua-Tai Xu Fu-Qiang Xu Zhi-Feng Liang Zi-Long Qiu; supported by National Natural Science Foundation of China grants (31625013 and 91732302);a Shanghai Brain-Intelligence Project of the Science and Technology Commission of Shanghai Municipality(16JC1420501);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDBS01060200);Program of Shanghai Academic Research Leader;the Open Large Infrastructure Research of Chinese Academy of Sciences;the Shanghai Municipal Science and Technology Major Project (2018SHZDZX05);National Natural Science Foundation of China (81801354)。; Methyl-CpG binding protein 2(MeCP2) is a basic nuclear protein involved in the regulation of gene expression and microRNA processing.Duplication of MECP2-containing genomic segments causes MECP2 duplication syndrome,a...; 关键词：MECP2 duplication Medial prefrontal cortex Social recognition deficit CRISPR-Cas9

Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism被引量：5: 《Neuroscience Bulletin》2017年第2期143-152,共10页Miao Wang Huiping Li Toru Takumi Zilong Qiu Xiu Xu Xiang Yu Wen-Jie Bian; supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences,China(XDB02010000);the National Natural Science Foundation of China(31530030 and 81371270);the Science and Technology Commission of Shanghai Municipality,China(16XD1404800); Autism spectrum disorder（ASD） encompasses a complex set of developmental neurological disorders,characterized by de？cits in social communication and excessive repetitive behaviors. In recent years, ASD is increasin...; 关键词：Autism Autism spectrum disorder Spine Spine formation Spinogenesis Spine pruning Gene duplication MECP2 15q11-13 duplication

Expression of Phospho-MeCP2s in the Developing Rat Brain and Function of Postnatal MeCP2 in Cerebellar Neural Cell Development被引量：2: 《Neuroscience Bulletin》2017年第1期1-16,共16页Fang Liu Jing-Jing Ni Feng-Yan Sun; supported by a grant from the National Natural Science Foundation of China(81030020); Abnormal expression and dysfunction of methyl-CpG binding protein 2 （MeCP2） cause Rett syndrome （RTT）. The diverse phosphorylation modifications modulate MeCP2 function in neural cells. Using western blot and immu...; 关键词：MECP2 Phospho-MeCP2 Braindevelopment CYTOPLASM ASTROCYTE CEREBELLUM

MeCP2:multifaceted roles in gene regulation and neural development被引量：5: 《Neuroscience Bulletin》2014年第4期601-609,共9页Tian-Lin Cheng Zilong Qiu; supported by the National Basic Research Development Program of China (2011CBA00400);the Strategic Priority Research Program of the Chinese Academy of Science,China (XDB02050400); Methyl-CpG-binding protein 2 （MeCP2） is a classic methylated-DNA-binding protein, dysfunctions of which lead to various neurodevelopmental disorders such as Rett syndrome and autism spectrum disorder. Initially reco...; 关键词：MECP2 Rett syndrome central nervous system gene expression regulation post-translationalmodification post-transcriptional regulation GLIA

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