The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than...
Aberrant sperm protamination is linked to sperm dysmorphology and nuclear chromatin condensation.Yet,its effects on sperm cytoplasmic maturation remain largely unexplored.The relationships of protamines,sperm morpholo...
Objective:Red blood cells are the predominant blood cell component utilized in transfusion therapy.Nevertheless,prolonged storage and the buildup of metabolites can lead to alterations in the structure and function of...
the National Natural Science Foundation of China(No.81770166,81720108002);Jiangsu Province’s Medical Elite Programme(China)(No.ZDRCA2016022);Project of National Key Clinical Specialty,Jiangsu Provincial Special Program of Medical Science(China)(No.BE2017751);National Science and Technology Major Project(China)(No.2018ZX09734007).
EBV-positive diffuse large B-cell lymphoma(DLBCL),which has a clonal EBV carrying proliferation of B-cells,defines a new DLBCL subtype and predicts a poor prognosis.Further studies are needed to explore the underlying...
supported by the National Natural Science Foundation of China(Projects 31725004,U22A20458);the Key Realm Research and Development Program of Guangdong Province(Project 2020B0202090001);the Natural Science Foundation of Guangdong Province(Project 2023A1515012038).
Calcium-dependent protein kinases(CDPKs/CPKs)are key regulators of plant stress signaling that translate calcium signals into cellular responses by phosphorylating diverse substrate proteins.However,the molecular mech...
supported by the National Natural Science Foundation of China (Nos. 92153303 and 21721005)。
G-quadruplex(G4) is widely known as a non-classical secondary structure of nucleic acid. With the indepth study of G4, it is an urgent need for a phosphorescent probe with a high G4 binding ability to evaluate the lev...
Stains are applied to impart contrast to the tissue and identify particular features of interest. However, the use of synthetic dyes as staining reagents has been associated with significant human health challenges an...
This work was supported by grants from the National Natural Science Foundation of China(91949106 and 31971080);the Natural Science Foundation of Beijing(7192125);the National Key R&D Program of China(2021YFA1100202);the Basic Research Projects of Basic Strengthening Program(2020-JCJQ-ZD-264);CAMS Innovation Fund for Medical Sciences(2021-I2M-1-019);Postdoctoral Research Funding in Hebei province(B2021005012).
Long non-coding RNAs(lncRNAs)are important regulators of diverse biological processes,especially skeletal muscle cell differentiation.Most of the lncRNAs identified to date are localized in the nucleus and play regula...
supported by grants from the National Natural Science Foundation of China(31788103);the Chinese Academy of Sciences(XDB27010301).
The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tr...
supported by CRI project(no.2018R1A3B1052702;J.S.K.)from the National Research Foundation of Korea(NRF);by the China Scholarship Fund(CSC no.201907030009;L.Y.);by the Interne Fondsen KU Leuven/Internal Funds KU Leuven(STG/19/029;P.V.).
The nucleolus,the locus of ribosome biogenesis,was found to be the predominant intracellular target of a new fluorescent probe,V-P1.In solution,the probe demonstrated both a selectivity to RNA G-quadruplexes and a sen...