METABOLISM

作品数：1845被引量：5652H指数：32
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Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging被引量：6
《Signal Transduction and Targeted Therapy》2022年第6期2105-2116,共12页Xin Li Jiaqiang Wang LeYun Wang Yuanxu Gao Guihai Feng Gen Li Jun Zou Meixin Yu Yu Fei Li Chao Liu Xue Wei Yuan Ling Zhao Hong Ouyang Jian-Kang Zhu Wei Li Qi Zhou Kang Zhang 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030400 to Q.Z.and W.L.);National Natural Science Foundation of China(31621004 to Q.Z.and W.L.,31471395 to Q.Z.,and 31701286 to G.F.);Guangzhou Laboratory(to K.Z.),the Key Research Projects of the Frontier Science of the Chinese Academy of Sciences(QYZDY-SSW-SMC002 to Q.Z.);the Key deployment projects of the Chinese Academy of Sciences(ZDRW-ZS-2017-4 to W.L.);the National Basic Research Program of China(2014cB964801 to W.L.);the China Postdoctoral Science Foundation(2017M610990 and 2017T100107 to J.W.);the China National Postdoctoral Program for Innovative Talents(BX201700243 to L.W.);the National Key Research and Development Program(2017YFA0103803 to Q.Z.).
Epigenetic alterations and metabolic dysfunction are two hallmarks of aging.However,the mechanism of how their interaction regulates aging,particularly in mammals,remains largely unknown.Here we show ELOVL fatty acid ...
关键词：METABOLISM alterations DYSFUNCTION 
Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function被引量：5
《Cell Research》2022年第1期54-71,共18页Xiang Xu Guangjin Ding Caizhi Liu Yuhan Ding Xiaoxin Chen Xiaoli Huang Chen-Song Zhang Shanxin Lu Yunpeng Zhang Yuanyong Huang Zhaosu Chen Wei Wei Lujian Liao Shu-Hai Lin Jingya Li Wei Liu Jiwen Li Sheng-Cai Lin Xinran Ma Jiemin Wong 
supported by grants from the Ministry of Science and Technology of China(2017YFA054201);the National Natural Science Foundation of China(31730048 and 31961133009 to J.W.);Shanghai Science and Technology Committee(20JC1411500 to J.W.);the National Natural Science Foundation of China(91957120 to S.H.L).
The AMP-activated protein kinase(AMPK)is a central regulator of energy homeostasis.Although much has been learned on how low energy status and glucose starvation activate AMPK,how AMPK activity is properly controlled ...
关键词：METABOLISM UHRF1 AMPK 
Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle被引量：2
《Cell Research》2021年第1期80-93,共14页Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei 
supported in part by the NIH grants(CA229307 and CA200573 to W.W.;CAI 83914 to L.W.;R01CA068490,P50CA101942 and R35CA210068 to W.G.K.);the National Basic Research Program of China(2015CB553602 to J.K.L.;2015CB856302 to J.G.L.);the National Natural Science Foundation of China(91649106,31570777,31770917 and 31700684 to J.K.L.;81802787 to Y.P.);Fundamental Research Funds for the Central Universities(08143008 and 08143101 to J.K.L.;zrzd2017013 to J.G.L.);American Cancer Society(to H.I.).
Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated wit...
关键词：SKP2 METABOLISM GLYCOLYSIS 
Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells
《Acta Biochimica et Biophysica Sinica》2021年第1期121-123,共3页Junfang Jia Yun Chen Lin Xu Yun Yang Xingxing Xu Hongyu Ding Caiwei Jia Hong Gao Pengxiang Guo Ronggui Hu 
This work was funded by the grants from the National Natural Science Foundation of China(Nos.31900804,81525019,and 31800700);the Ministry of Science and Technology of China(Nos.2019YFA0802103,2018YFA0508200,and 2018ZX10101004)to R.H,the Guangzhou Science Innovation and Development program(No.201803010092);R.H.was also financially supported by the State Key Laboratory of Dairy Techniques in Guangming Dairy Inc.and the C A S Instrument Developing Project(No.YZ201339).
G protein-coupled receptor 119(GPR119),encoded by human GPR119 gene,is considered as a novel member of cannabinoid receptors.GPR119 is expressed predominantly in the pancreas and gastrointestinal tract of rodents and ...
关键词：METABOLISM INTAKE diseases 
Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level被引量：5
《Cell Research》2020年第12期1109-1126,共18页Xin Wang Li Yang Yan-Chun Wang Zi-Ran Xu Ye Feng Jing Zhang Yi Wang Cheng-Ran Xu 
the National Key R&D Program of China(2019YFA0801500);the National Basic Research Program of China(2015CB942800);the National Natural Science Foundation of China(31521004,31522036);the SLS-Qidong Innovation Fund,as well as funding from the Peking-Tsinghua Center for Life Sciences to C.-R.X.
During embryogenesis,the liver is the site of hepatogenesis and hematopoiesis and contains many cell lineages derived from the endoderm and mesoderm.However,the characteristics and developmental programs of many of th...
关键词：hepato FETAL METABOLISM 
The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals被引量：35
《Cell Research》2020年第9期717-731,共15页Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium 
supported by the National Basic Research Program of China(973 Program;2015CB553601);the National Natural Science Foundation of China(81530020,81522032,81842015,81390352,81621061,81622011,and 81770842);the National Key R&D Program(2016YFC0905001,2017YFC0909703,2016YFC0901201,2016YFC1305600,2016YFC1305202,2017YFC1310700,2018YFC1311800,and 2018YFC1311705).
Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Me...
关键词：METABOLISM PREVENTION BASES 
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer被引量：6
《Signal Transduction and Targeted Therapy》2020年第1期1857-1870,共14页Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong 
supported by the National Key Research and Development Program of China(No.2017YFC1308604);the Shanghai Program for Innovative Research Team in Universities,the National Natural Science Foundation of China(No.81802903,81672820,81772563,81930074 and 81872356);the NSFC Program of International Cooperation and Exchanges(No.81120108016);the National Key Basic Research Program of China(No.2013CB910500 and 2014CB542101);China National Key Projects for Infectious Disease(No.2012ZX10002-012).
Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of...
关键词：HDAC3 METASTASIS METABOLISM 
Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc被引量：4
《Cellular & Molecular Immunology》2019年第9期757-769,共13页Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su 
This study was partially supported by grant PR093728(DoD to B.S.);the National Natural Science Foundation of China(grant numbers 31470845 and 81430033 to B.S.,31422020 to F.L.and 31600704 to H.H.Z.);grant 13JC1404700 from the Program of Science and Technology Commission of Shanghai Municipality(B.S.);the Ministry of Science and Technology of China(Program 2014CB943600,F.L.);Chinese Mega Project on Infectious Diseases(No.2018ZX10302301).
Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2...
关键词：METABOLISM IMMUNITY STIMULATION 
Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome被引量：30
《Signal Transduction and Targeted Therapy》2019年第1期264-297,共34页Ziying Zhang Haosheng Tang Peng Chen Hui Xie Yongguang Tao 
This work was supported by the National Natural Science Foundation of China(81672787[Y.T.]);the National Basic Research Program of China(2015CB553903[Y.T.]);an the Overseas Expertise Introduction Project for Discipline Innovation(111 Project,No.111-2-12).
The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology.Remarkable progress in large...
关键词：METABOLISM IMMUNITY MANIPULATION 
History and progress of hypotheses and clinical trials for Alzheimer’s disease被引量：34
《Signal Transduction and Targeted Therapy》2019年第1期412-433,共22页Pei-Pei Liu Yi Xie Xiao-Yan Meng Jian-Sheng Kang 
We appreciate funding by the National Natural Science Foundation of China(Grant No.31171369);the National Basic Research Program(973 Program)(Nos 2011CB910903 and 2010CB912001);the Chinese Academy of Sciences(Hundred Talents Program and 2009OHTP10);the Joint Construction Project of Henan Province(No.2018020088 and No.2018020114),and the First Affiliated Hospital of Zhengzhou University.
Alzheimer’s disease(AD)is a neurodegenerative disease characterized by progressive memory loss along with neuropsychiatric symptoms and a decline in activities of daily life.Its main pathological features are cerebra...
关键词：ALZHEIMER METABOLISM CLINICAL 
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