White adipose tissue is a highly specialized organ that not only stores excess calories but also helps control systemic energy and glucose metabolism as an active endocrine organ.Fu et al.’s new study in Cell Researc...
supported by the National Natural Science Foundation of China(92169116,81971499,31722019,82070765,82388201,82303198);Key Project of Natural Science Foundation of Zhejiang Province(LZ20H290001);Shanghai Shuguang Program(19SG33).
Immunometabolism is critical in the regulation of immunity and inflammation;however,the mechanism of preventing aberrant activation-induced immunopathology remains largely unclear.Here,we report that glyoxalase II(GLO...
supported by the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803800,2019YFA0801900,NSFC92057115);Shanghai Sailing Program 20YF1402600 to H.H.,the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803600,2018YFA0801300,2023YFA1801000 to J.L.);the National Natural Science Foundation of China(32071138 and 32371193 to J.L.),and SKLGE-2118 to J.L.
Neurotensin(NTS)is a secretory peptide produced by lymphatic endothelial cells.Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2.In the current study,we f...
The capacity to effectively adapt metabolism to environmental demands is crucial for cell viability,proliferation,and function.Recent discoveries in Cell Research have highlighted the role of the lysosomal pool of AMP...
funded by the National Key R&D Program of China(2021YFA1302300 to Z.Z.);the National Natural Science Foundation of China(32171201 to Z.Z.);The study was also supported by the Center for Life Sciences School of Life Sciences of Peking University,the State Key Laboratory of Membrane Biology of China(to Z.Z.),and ALSAC(to C.-H.L.).
Dear Editor,Vitamins B,and Bo are two water-soluble vitamins.Their active forms thiamine pyrophosphate and pyridoxal 5'-phosphate serve as cofactors for numerous enzymes involved in multiple biochemical reactions that...
supported by the Science&Technology Initiative projects,the STI 2030-Major Project (2021ZD0203400 to J.-F.C.);the STI 2030-Major Project (2022ZD0208300 to Z.W.);the National Natural Science Foundation of China (82101556 to X.Z.,82151308 to J.-F.C,31970948 and 31600859 to W.G.,81971031 to Z.L,818700073 to X.C.,81971064 to Y.Z.);the Research Fund for International Senior Scientists (82150710558 to J.-F.C.);the Key Research Project (2023C03079 to J.-F.C.)from Zhejiang Provincial Administration of Science&Technology,the Natural Science Foundation of Zhejiang Province of China grant (LQ22H090013 to X.Z.);the Start-up Fund (OJQDSP2022007 to J.-F.C.)from the Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health);the Program Project from the State Key Laboratory of Ophthalmology,Optometry and Vision Science,Wenzhou Medical University (Jo1-20190101 to J.-F.C.)。
Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders.However,the lack of a neurochemical underpinning has hampered its therapeutic devel...
supported by the Ministry of Science and Technology of China(2021YFA0804700);the National Natural Science Foundation of China(31771490);Shanghai Science and Technology Commission(20JC1410500);UK Medical Research Council(MC_UU_12021/3,MC_U137788471)to J.L.L.
Dear Editor,Glutaminase catalyzes the first step of glutamine metabolism,converting glutamine to glutamate,which enters the tricarboxylic acid cycle.In human,glutaminase is encoded by two different genes,GLS1 and GLS2...
supported by grants from the National Key R&D Program of China(2018YFA0507103 to X.J.,2021YFA1301500 to F.S.);the National Natural Science Foundation of China(32270139 to X.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37040102 to F.S.);the National Natural Science Foundation of China(32071187 to Y.Z.);the National Key Research and Development Program(2019YFA0904101 to Y.Z.);the program for Innovative Talents and Entrepreneur in Jiangsu;the Fundamental Research Funds for the Central Universities.
Dear Editor,In the nematode Caenorhabditis elegans,the systemic RNA interference defective protein 1(SID-1)plays a crucial role in systemic RNA interference(RNAi)by facilitating the transport of exogenous double-stran...
Multifunctional metabolites are widely involved in physiological and pathological processes as signaling molecules,sensors,epigenetic modification substrates and so on,in addition to being energy substances.In a recen...
A recent study by Yuan et al.in Nature explores the biological mechanisms underlying lysine catabolism and implicates histone crotonylation in antitumor immunity.Cancer and cancer-associated immune cells alter metabol...