METABOLISM

作品数:1864被引量:5736H指数:32
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相关领域:医药卫生更多>>
相关作者:钟大放钱之玉王广基柳晓泉李燕更多>>
相关机构:沈阳药科大学中国科学院浙江大学清华大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Neurotensin signaling in fat modulates food intake
《Cell Research》2025年第2期85-86,共2页YoungUk Jang Prashant Rajbhandari 
White adipose tissue is a highly specialized organ that not only stores excess calories but also helps control systemic energy and glucose metabolism as an active endocrine organ.Fu et al.’s new study in Cell Researc...
关键词:INTAKE METABOLISM 
Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
《Cell Research》2025年第2期97-116,共20页Qihang Zhao Qiang Wang Qinghua Yao Zhengdong Yang Wenfang Li Xiaojie Cheng Yingling Wen Rong Chen Junfang Xu Xuanying Wang Dexiang Qin Shuyang Zhu Liujie He Nan Li Yanfeng Wu Yizhi Yu Xuetao Cao Pin Wang 
supported by the National Natural Science Foundation of China(92169116,81971499,31722019,82070765,82388201,82303198);Key Project of Natural Science Foundation of Zhejiang Province(LZ20H290001);Shanghai Shuguang Program(19SG33).
Immunometabolism is critical in the regulation of immunity and inflammation;however,the mechanism of preventing aberrant activation-induced immunopathology remains largely unclear.Here,we report that glyoxalase II(GLO...
关键词:INFLAMMATORY INFLAMMATION METABOLISM 
Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism
《Cell Research》2025年第2期117-131,共15页Wei Fu Yuanting Lai Kexin Li Yue Yang Xiao Guo Qifan Gong Xiaofeng Zhou Liying Zhou Cenxi Liu Zhi Zhang Jisun So Yufeng Zhang Lin Huang Guangxing Lu Chuanyou Yi Qichu Wang Chenyu Fan Chao Liu Jiaxing Wang Haiyi Yu Yimin Zhao Tao Huang Hyun Cheol Roh Tiemin Liu Huiru Tang Jianping Qi Ming Xu Yan Zheng He Huang Jin Li 
supported by the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803800,2019YFA0801900,NSFC92057115);Shanghai Sailing Program 20YF1402600 to H.H.,the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803600,2018YFA0801300,2023YFA1801000 to J.L.);the National Natural Science Foundation of China(32071138 and 32371193 to J.L.),and SKLGE-2118 to J.L.
Neurotensin(NTS)is a secretory peptide produced by lymphatic endothelial cells.Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2.In the current study,we f...
关键词:INTAKE METABOLISM Together 
Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
《Cell Research》2024年第12期822-823,共2页Benoit Viollet Bruno Guigas 
The capacity to effectively adapt metabolism to environmental demands is crucial for cell viability,proliferation,and function.Recent discoveries in Cell Research have highlighted the role of the lysosomal pool of AMP...
关键词:METABOLISM function. LYSOSOMAL 
Substrate and drug recognition mechanisms of SLC19A3
《Cell Research》2024年第6期458-461,共4页Yu Dang Tianyi Zhang Shabareesh Pidathala Guopeng Wang Yijie Wang Nanhao Chen Chen Song Chia-Hsueh Lee Zhe Zhang 
funded by the National Key R&D Program of China(2021YFA1302300 to Z.Z.);the National Natural Science Foundation of China(32171201 to Z.Z.);The study was also supported by the Center for Life Sciences School of Life Sciences of Peking University,the State Key Laboratory of Membrane Biology of China(to Z.Z.),and ALSAC(to C.-H.L.).
Dear Editor,Vitamins B,and Bo are two water-soluble vitamins.Their active forms thiamine pyrophosphate and pyridoxal 5'-phosphate serve as cofactors for numerous enzymes involved in multiple biochemical reactions that...
关键词:VITAMIN METABOLISM SLC 
40 Hz light flickering promotes sleep through cortical adenosine signaling被引量:5
《Cell Research》2024年第3期214-231,共18页Xuzhao Zhou Yan He Tao Xu Zhaofa Wu Wei Guo Xi Xu Yuntao Liu Yi Zhang Huiping Shang Libin Huang Zhimo Yao Zewen Li Lingya Su Zhihui Li Tao Feng Shaomin Zhang Olivia Monteiro Rodrigo A.Cunha Zhi-Li Huang Kang Zhang Yulong Li Xiahong Cai Jia Qu Jiang-Fan Chen 
supported by the Science&Technology Initiative projects,the STI 2030-Major Project (2021ZD0203400 to J.-F.C.);the STI 2030-Major Project (2022ZD0208300 to Z.W.);the National Natural Science Foundation of China (82101556 to X.Z.,82151308 to J.-F.C,31970948 and 31600859 to W.G.,81971031 to Z.L,818700073 to X.C.,81971064 to Y.Z.);the Research Fund for International Senior Scientists (82150710558 to J.-F.C.);the Key Research Project (2023C03079 to J.-F.C.)from Zhejiang Provincial Administration of Science&Technology,the Natural Science Foundation of Zhejiang Province of China grant (LQ22H090013 to X.Z.);the Start-up Fund (OJQDSP2022007 to J.-F.C.)from the Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health);the Program Project from the State Key Laboratory of Ophthalmology,Optometry and Vision Science,Wenzhou Medical University (Jo1-20190101 to J.-F.C.)。
Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders.However,the lack of a neurochemical underpinning has hampered its therapeutic devel...
关键词:SLEEP METABOLISM SUSTAINED 
Structural basis for activation and filamentation of glutaminase
《Cell Research》2024年第1期76-79,共4页Chen-Jun Guo Zi-Xuan Wang Ji-Long Liu 
supported by the Ministry of Science and Technology of China(2021YFA0804700);the National Natural Science Foundation of China(31771490);Shanghai Science and Technology Commission(20JC1410500);UK Medical Research Council(MC_UU_12021/3,MC_U137788471)to J.L.L.
Dear Editor,Glutaminase catalyzes the first step of glutamine metabolism,converting glutamine to glutamate,which enters the tricarboxylic acid cycle.In human,glutaminase is encoded by two different genes,GLS1 and GLS2...
关键词:METABOLISM KIDNEY ACTIVATION 
Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity被引量:1
《Cell Research》2024年第1期80-83,共4页Le Zheng Tingting Yang Hangtian Guo Chen Qi Yuchi Lu Haonan Xiao Yan Gao Yue Liu Yixuan Yang Mengru Zhou Henry CNguyen Yun Zhu Fei Sun Chen-Yu Zhang Xiaoyun Ji 
supported by grants from the National Key R&D Program of China(2018YFA0507103 to X.J.,2021YFA1301500 to F.S.);the National Natural Science Foundation of China(32270139 to X.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37040102 to F.S.);the National Natural Science Foundation of China(32071187 to Y.Z.);the National Key Research and Development Program(2019YFA0904101 to Y.Z.);the program for Innovative Talents and Entrepreneur in Jiangsu;the Fundamental Research Funds for the Central Universities.
Dear Editor,In the nematode Caenorhabditis elegans,the systemic RNA interference defective protein 1(SID-1)plays a crucial role in systemic RNA interference(RNAi)by facilitating the transport of exogenous double-stran...
关键词:METABOLISM IMMUNITY transport 
An idle PHGDH takes control of cell fate
《Cell Research》2023年第12期894-895,共2页Linchong Sun Ping Gao 
Multifunctional metabolites are widely involved in physiological and pathological processes as signaling molecules,sensors,epigenetic modification substrates and so on,in addition to being energy substances.In a recen...
关键词:occupied ADDITION METABOLISM 
Lysine metabolism at the nexus of crotonylation and tumor immunity
《Cell Research》2023年第11期813-814,共2页Fangchao Wei Jason W.Locasale 
A recent study by Yuan et al.in Nature explores the biological mechanisms underlying lysine catabolism and implicates histone crotonylation in antitumor immunity.Cancer and cancer-associated immune cells alter metabol...
关键词:function. ROTON METABOLISM 
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