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检索条件："关键词=N-acetyltransferase "
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Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration
《Neural Regeneration Research》2025年第10期2862-2871,共10页Prajakta Deshpande Anuradha Venkatakrishnan Chimata Amit Singh 
supported by 1RO1EY032959-01 and RO1 supplement from NIH,Schuellein Chair Endowment Fund and STEM Catalyst Grant from the University of Dayton(to AS).
Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivo...
关键词：acetyl-coenzyme A Alzheimer’s disease animal models cell death DROSOPHILA eye human disease c-Jun N-terminal kinase signaling N-Acetyltransferases N-acetyltransferase 9 NEURODEGENERATION 
N-乙酰化转移酶基因多态性与肺癌易感性关系的研究进展被引量：1
《国际呼吸杂志》2007年第16期1224-1226,共3页郭占林 高旭东 
内蒙古自然科学基金资助项目（编号：200607010929）;内蒙古医学院附属医院重大科研资助项目
代谢酶在外源性致癌物的体内代谢中起重要的激活与灭活作用。N-乙酰化转移酶（arylamine N-acetyltransferases,NAT）是人体内重要的致癌物灭活酶。编码代谢酶的基因存在着多态性现象,可导致代谢酶活性不同,使外源性致癌物在体内代谢存...
关键词：肺肿瘤 易感性 N-乙酰化转移酶 基因多态性 
糖皮质激素联合丙种球蛋白对重症药疹患者N-乙酰基转移酶活性的影响被引量：2
《中国社区医师》2018年第8期58-58,60,共2页汪小柳 刘志军 
衡阳市2015科学技术发展计划项目;编号2015KJ47~~
目的:检测糖皮质激素联合丙种球蛋白对N-乙酰基转移酶活性的影响,探讨糖皮质激素联合丙种球蛋白治疗重症药疹可能的机制。方法:收集正常人和重症药疹患者经糖皮质激素联合丙种球蛋白治疗前后尿液,采用反相高效液相色谱技术,检测尿液中...
关键词：重症药疹 糖皮质激素 丙种球蛋白 N-乙酰基转移酶 RP-HPLC 
Inflammatory cytokines suppress arylamine N-acetyltransferase 1 in cholangiocarcinoma cells被引量：1
《World Journal of Gastroenterology》2007年第46期6219-6225,共7页Benjaporn Buranrat Auemduan Prawan Banchob Sripa Veerapol Kukongviriyapan 
Khon Kaen University Research Fund,Grant from National Science and Technology Development Agency through the Research-Yeam-Strenghtening Grant Scheme 2006
AIM： To evaluate the effect of inflammatory cytokines on arylamine N-acetyltransferase 1 （NAT1）, which is a phase-U enzyme involved in the biotransformation of aromatic and heterocyclic amines found in food, drugs ...
关键词：Arylamine N-acetyltransferase 1 Phase lldrug-metabolizing enzyme Inflammatory cytokine Oxidative stress CHOLANGIOCARCINOMA 
Relationship between metabolic enzyme polymorphism and colorectal cancer被引量：10
《World Journal of Gastroenterology》2005年第3期331-335,共5页KunChen Qin-TingJiang Han-QingHe 
Supported by the National Natural Science Foundation of China, No. 30170828
AIM: To clarify the influence of genetic polymorphisms on colorectal cancer. METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonia...
关键词：Colorectal cancer Glutathione S-transferase T1 N-ACETYLTRANSFERASE POLYMORPHISM 
Evolutionary genomics analysis reveals gene expansion and functional diversity of arylalkylamine N-acetyltransferases in the Culicinae subfamily of mosquitoes
《Insect Science》2023年第2期569-581,共13页Yu Tang Huaqing Chen Zhinan Lin Lei Zhang Archana Upadhyay Chenghong Liao David J.Merkler Qian Han 
supported by the National Natural Science Foundation of China(31860702 and 31960703);by the Hainan Province Science and Technology Special Fund(ZDKJ2021035).
Arylalkylamine N-acetyltransferase(aaNAT),considered a potential new insecticide target,catalyzes the acetylation of arylalkylamine substrates such as serotonin and dopamine and,hence,mediates diverse functions in ins...
关键词：arylalkylamine N-acetyltransferase functional diversity gene duplication molecular evolution MOSQUITO N-acyltransferase 
N-acetyltransferase 2: Slow, intermediate or fast? A booming question of the molecular epidemiology in cancer research
《Open Journal of Genetics》2012年第4期221-235,共15页Giuliano Di Pietro Sandra Rocha Gadelha Sandra Mara Bispo Sousa Paulo Roberto Santana de Melo Fabricio Rios Santos 
Throughout history, humanity has referred to reactions occurring with food, plants and, recently, medicines or drugs. The increase in pulmonary tuberculosis cases and the availability of treatment showed that genetic ...
关键词：Cancer ETHNICITY Genetic VARIANTS N-ACETYLTRANSFERASE 2 
What a Role did Histidine Residue Play in Arylamine N-Acetyltransferase 2 Acetylation？ A Quantum Chemistry Study
《Chinese Journal of Chemistry》2006年第10期1279-1281,共3页乔青安 蔡政亭 杨传路 王美山 
Project supported by the Youth Natural Science Foundation of Yantai Normal University （No. 042902）, the Youth Natural Science Foundation of Shandong Provincial Education Department （No. 200139） and the National Natural Scientific Foundation of China （Nos. 20173032, 10404030 and 20373071）.
Arylamine N-acetyltransferases （NATs, EC 2.3.1.5） catalyze an acetyl group transfer from acetyl coenzyme A （AcCoA） to primary arylamines and play a very important role in the metabolism and bioactivation of drugs ...
关键词：arylamine N-acetyltransferase 2 density functional theory acetyl transfer role of His-107 
NAT2基因多态性与疾病遗传易感性的关系被引量：3
《医学综述》2006年第1期20-21,共2页欧阳晓春 刘振华 
许多疾病的发病与环境因素以及个体对解毒酶的遗传易感性相关,N-乙酰基转移酶-2突变导致酶活性功能减少。本文就代谢酶NAT2基因多态性与肿瘤、帕金森病、阿尔茨海默病遗传易感性进行综述。
关键词：N-乙酰基转移酶 多态性 遗传易感性 
基于N-乙酰转移酶研究槲皮素对大鼠体内异烟肼代谢的影响
《中国药物警戒》2021年第2期121-125,共5页饶志 臧凯宏 王晓华 秦红岩 
甘肃省自然科学基金项目(1606RJZA117):以NAT为靶标筛选5-氨基水杨酸增效剂及其活性验证;甘肃省中医药管理局项目(GZK-2018-46):基于NAT筛选具有异烟肼增效作用的中药成分。
目的基于N-乙酰转移酶(NAT)的表达及活性检测,研究槲皮素对大鼠体内异烟肼(INH)代谢及药动学特征影响。方法雄性Wistar大鼠单独灌胃给予INH(60 mg/kg)或槲皮素(50 mg/kg)联合INH(60 mg/kg)。分别于给药后不同时间收集血清,应用液质联用...
关键词：异烟肼 槲皮素 N-乙酰基转移酶 药动学 
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