N-ACETYLTRANSFERASE

作品数：27被引量：120H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：刘永军董丽花更多>>
相关机构：山东大学浙江省医学科学院武汉大学更多>>
相关期刊：《Journal of Life Sciences》《Insect Science》《Open Journal of Genetics》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration
《Neural Regeneration Research》2025年第10期2862-2871,共10页Prajakta Deshpande Anuradha Venkatakrishnan Chimata Amit Singh 
supported by 1RO1EY032959-01 and RO1 supplement from NIH,Schuellein Chair Endowment Fund and STEM Catalyst Grant from the University of Dayton(to AS).
Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivo...
关键词：acetyl-coenzyme A Alzheimer’s disease animal models cell death DROSOPHILA eye human disease c-Jun N-terminal kinase signaling N-Acetyltransferases N-acetyltransferase 9 NEURODEGENERATION 
Targeting N4-acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2-mediated HMGB2 mRNA translation
《Cancer Communications》2024年第9期1018-1041,共24页Hailing Liu Lei Xu Shiwei Yue Hongfei Su Xing Chen Qiumeng Liu Hui Li Huifang Liang Xiaoping Chen Jiefeng He Zeyang Ding Bixiang Zhang 
State Key Project on Infection Disease of China,Grant/Award Number:2018ZX10723204-003-003;Tongji Hospital(HUST)Foundation for Excellent Young Scientist,Grant/Award Number:2020YQ05;National Basic Research Program of China,Grant/Award Number:2020YFA0710700;Knowledge Innovation Program ofWuhan-Shuguang Project,Grant/Award Number:2022020801020456;the first level of the public health youth top talent project of Hubei province,Grant/Award Number:2022SCZ051;National Natural Science Foundation of China,Grant/Award Numbers:81874065,81874189,82203823,82273441。
Background:N4-acetylcytidine(ac4C)represents a novel messenger RNA(mRNA)modification,and its associated acetyltransferaseN-acetyltransferase 10(NAT10)plays a crucial role in the initiation and progression of tumors by...
关键词：N4-acetylcytidine N-acetyltransferase 10 hepatocellular carcinoma mRNA translation targeted therapy 
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
《Acta Pharmacologica Sinica》2024年第7期1425-1437,共13页Xiu-xiu Wang Yi-ming Zhao Qian-yun Zhang Jing-xuan Zhao Dao-hong Yin Zi-zhen Zhang Xiao-yan Jin Shuai-nan Li Hao-yu Ji Hong-yang Chen Xiao-fei Guo Yang Yu Wen-ya Ma Hong Yan Han Li Qi-meng Ou-Yang Zhen-wei Pan Hai-hai Liang Ning Wang Wei Chen Ben-zhi Cai Yu Liu 
supported by Heilongjiang Touyan Innovation Team Program [B.Z.C],HMU Marshal Initiative Funding (HMUMIF-21018);the National Natural Science Foundation of China [82272389/92168119/82100300/82000226].
Cardiac fibrosis is a pathological scarring process that impairs cardiac function.N-acetyltransferase 10(Nat10)is recently identified as the key enzyme for the N4-acetylcytidine(ac4C)modification of mRNAs.In this stud...
关键词：cardiac fibrosis N-acetyltransferase 10 ac4C-RIP-sequencing Hippo signaling pathway angiomotin-like 1 
NAT10-mediated ac 4 C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1被引量：1
《Cancer Communications》2024年第3期361-383,共23页Daojia Miao Jian Shi Qingyang Lv Diaoyi Tan Chuanyi Zhao Zhiyong Xiong Xiaoping Zhang 
This study was supported by the National Natural Sci-ence Foundation of China(81874090,81972630,82202911,82300786).
Background:Lymphatic metastasis is one of the most common metastatic routes and indicates a poor prognosis in clear-cell renal cell carcinoma(ccRCC).N-acetyltransferase 10(NAT10)is known to catalyze N4-acetylcytidine(...
关键词：clear-cell renal cell carcinoma N4-acetylcytidine N-acetyltransferase 10 YAP1 nuclear import 
N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA被引量：18
《Cancer Communications》2022年第12期1347-1366,共20页Xiao Zheng Qi Wang You Zhou Dachuan Zhang Yiting Geng Wenwei Hu Changping Wu Yufang Shi Jingting Jiang 
National Natural Science Foundation of China,Grant/Award Numbers:81902386,81972869,82002479;The Natural Science Foundation of Jiangsu Province,Grant/Award Numbers:BK20211065,BK20200179;China Postdoctoral Science Foundation,Grant/Award Number:2021M700547;Youth Talent Science and Technology Project of Changzhou Health Commission,Grant/Award Number:QN202103;The open fund of state key laboratory of Pharmaceutical Biotechnology,Nanjing University,China,Grant/Award Number:KF-202203。
Background:N-acetyltransferase 10(NAT10)is the only enzyme known tomediate the N4-acetylcytidine(ac4C)modification of mRNA and is crucial formRNA stability and translation efficiency.However,its role in cancer develop...
关键词：Colon cancer N-acetyltransferase 10(NAT10) N4-acetylcytidine(ac4C) Ferroptosis suppressor protein 1(FSP1) Ferroptosis mRNA stability RNA acetylation 
Arylalkalamine N-acetyltransferase-1 functions on cuticle pigmentation in the yellow fever mosquito,Aedes aegypti
《Insect Science》2021年第6期1591-1600,共10页Lei Zhang Miao-Zhen Li Zhao-Hui Chen Yu Tang Cheng-Hong Liao Qian Han 
supported by National Natural Science Foundation of China(31860702;31960703);Postgraduate Innovation Research Project of General Higher Education in Hainan Province,China(Hyb2018-08).
Arylalkylamine N-acetyltransferase(aaNAT)catalyzes the acetylation of dopamine,5-hydroxy-tryptamine,tryptamine,octopamine,norepinephrine and other ary-lalkylamines to form respective N-acetyl-arylalkylamines.Depending...
关键词：arylalkylamine Aedes aegypti CRISPR-Cas9 cuticle pigmentation gene expression N-ACETYLTRANSFERASE 
Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells被引量：3
《Acta Pharmacologica Sinica》2018年第4期597-606,共10页Dong CHEN Yi-pei LI Yan-xia YU Tian ZHOU Chao LIU Er-kang FEI Feng GAO Chen-chen MU Hai-gang REN Guang-hui WANG 
Dendritic cell nuclear protein-1 （DCNP1） is a protein associated with major depression. In the brains of depression patients, DCNP1 is up-regulated. However, how DCNP1 participates in the pathogenesis of major depre...
关键词：major depression DCNP1 N-ACETYLTRANSFERASE MELATONIN circadian system BMAL1 rat glioma cell line C6 
Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes被引量：3
《Acta Pharmaceutica Sinica B》2017年第4期517-522,共6页Mark A.Doll Raúl A.Salazar-González Srineil Bodduluri David W.Hein 
supported by National Institutes of Health grants R25-CA134283 and P20-GM113226(USA)
Cryopreserved human hepatocytes were used to investigate the role of arylamine N-acetyltransferase 2 (NAT2; EC 2.3.1.5) polymorphism on the N-acetylation of isoniazid (INH). NAT2 genotype was determined by Taqman alle...
关键词：ISONIAZID N-Acetyltransferase 2 Acetylation polymorphism Human hepatocytes GENOTYPE PHENOTYPE 
Molecular Docking and ADMET Study of Emodin Derivatives as Anticancer Inhibitors of NAT2, COX2 and TOP1 Enzymes
《Computational Molecular Bioscience》2017年第1期1-18,共18页Daniel M. Shadrack Valence M. K. Ndesendo 
Over the past years natural products and/or their derivatives have continued to provide cancer chemotherapeutics. Glycosides derivatives of emodin are known to possess anticancer activities. An in silico study was car...
关键词：Human ARYLAMINE N-ACETYLTRANSFERASE 2 (NAT2) Cyclooxygenase 2 (COX2) TOPOISOMERASE 1 (TOP1) EMODIN In Silico Inhibition Pharmacokinetics Molecular Docking 
Isoniazid metabolism and hepatotoxicity被引量：23
《Acta Pharmaceutica Sinica B》2016年第5期384-392,共9页Pengcheng Wang Komal Pradhan Xiao-bo Zhong Xiaochao Ma 
supported in part by the U.S. National Institute of Diabetes and Digestive and Kidney Diseases (DK090305) for Xiaochao Ma;the National Institute of General Medical Sciences (GM087376 and GM118367) for Xiao-bo Zhong
Isoniazid(INH) is highly effective for the management of tuberculosis.However,it can cause liver injury and even liver failure.INH metabolism has been thought to be associated with INH-induced liver injury.This review...
关键词：ISONIAZID METABOLISM HEPATOTOXICITY ANTI-TUBERCULOSIS N-ACETYLTRANSFERASE 2 AMIDASE 
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