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A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance
《Chinese Chemical Letters》2024年第7期313-318,共6页Jingqi Xin Shupeng Han Meichen Zheng Chenfeng Xu Zhongxi Huang Bin Wang Changmin Yu Feifei An Yu Ren 
supported by the National Natural Science Foundation of China(Nos.51903201,82172798);the Natural Science Foundation of Shaanxi Province(No.2023-YBSF-270);the Open Program of NHC Key Laboratory of Nuclear Medicine and Jiangsu Key Laboratory of Molecular Nuclear Medicine(No.KF202203);Horizontal Project of the First Affiliated Hospital of Xi'an Jiaotong University(No.202304174)。
Tumor microenvironment(TME)-activatable probes have been proven to effectively increase signal-tobackground ratios(SBRs)and improve the success rate of complete tumor resection.However,many fluorescence probes have to...
关键词：NITROREDUCTASE Tumor diagnosis Intraoperative guidance Self-assembly NANOPROBE 
鱼类神经坏死病毒纳米探针的制备与特征分析
《中国动物检疫》2015年第6期75-78,共4页粟子丹 史成银 刘江春 王胜强 
国家科技支撑计划课题(2012BAD17B01)
为了快速检测鱼类神经坏死病毒,本研究设计了病毒特异性的发夹型探针,经硫醇修饰后与纳米银溶胶结合,制备了鱼类神经坏死病毒纳米探针(Ag-NNV),并使用透射电镜、多功能酶标仪、表面增强拉曼光谱仪等对纳米探针Ag-NNV的表征及发夹型探针...
关键词：纳米探针 神经坏死病毒 表面增强拉曼散射 
纳米技术在动脉粥样硬化中的应用与研究进展
《实用医学杂志》2024年第1期53-58,共6页王婷婷 于莉莉 沈祥丽 郑峻萌 陈玉善 尚莎莎 王建茹 
国家重点研发计划(编号:2020YFC2004706);国家自然科学基金项目(编号:82004311);河南省中医管理局中医药科学研究专项课题(编号:2019JDZX2044)。
动脉粥样硬化(atherosclerosis,AS)是一种常见的心血管疾病,其治疗和预防一直是医学界的研究热点。纳米技术作为一种新兴技术,具有独特的优势,可以在AS的预防、诊断和治疗中发挥重要作用。本文就纳米技术在AS疾病中应用的最新研究进行综...
关键词：动脉粥样硬化 纳米技术 靶向作用 纳米探针 
Magnetic-Optical Imaging for Monitoring Chemodynamic Therapy
《Chemical Research in Chinese Universities》2022年第2期481-492,共12页WANG Youjuan YE Zhifei SONG Guosheng LIU Zhuang 
supported by the National Natural Science Foundation of China(Nos.21804039 and 51872088);the Science and Technology Project of Hunan Province,China(No.2020RC3022);the Fundamental Research Funds for the Central Universities,China.
Chemodynamic therapy kills cancer cells with reactive oxygen species generated by endogenous triggers in the tumor microenvironment.Although chemodynamic therapy is blossoming in recent years,their therapy process sti...
关键词：Chemodynamic therapy Magnetic imaging Optical imaging NANOPROBE Monitoring therapeutic response 
基于纳米探针检测食源性肠炎沙门氏菌技术初探被引量：6
《食品安全质量检测学报》2017年第11期4318-4321,共4页刘慧玲 涂晓波 吕敬章 黄欣迪 吴绍精 洪小柳 葛丽雅 黄李华 张恒 
国家自然科学青年基金项目(31401585);深圳市科技计划基础研究项目(JCYJ20140419151654444);国家质量监督检验检疫总局科技计划项目(2016IK236)~~
目的建立纳米探针快速、准确检测食源性肠炎沙门氏菌的方法。方法利用二氧化硅磁纳米材料与肠炎沙门氏菌抗体制备纳米探针,将制备后的探针与经过荧光染色的肠炎沙门氏菌结合,并通过荧光显微镜和流式细胞仪对探针捕获的细菌进行检测,并比...
关键词：纳米探针 流式细胞术 肠炎沙门氏菌 荧光显微镜 
适于纳米探针电性能测试的SRAM样品制备方法
《半导体技术》2020年第5期404-408,共5页曹守政 庞凌华 钱洪涛 
在先进制程静态随机存储器(SRAM)单比特失效的分析过程中,SRAM样品制备是关键,传统研磨方法制备的样品其表面容易出现钨栓缺失的问题。利用离子精密刻蚀仪制备用于纳米探针电性能测试的SRAM样品。通过刻蚀仪改变刻蚀能量和刻蚀角度来制...
关键词：失效分析 样品制备 精密刻蚀 纳米探针 静态随机存储器(SRAM) 
A Biomimetic Membrane-Coated Nanoprobe for the Ratiometric Fluorescence Detection of Phospholipase A_(2)
《Journal of Analysis and Testing》2024年第3期270-277,共8页Xingyu He Yuanyuan Dong Pan He Chenghui Liu Wei Ren 
supported by the National Natural Science Foundation of China(21904083);the Program for Changjiang Scholars and Innovative Research Team in University(IRT_15R43);the Fundamental Research Funds for the Central Universities(GK202201009,GK202101001,and GK202305001);the Innovation Capability Support Program of Shaanxi Province(2021TD-42).
Phospholipase A_(2)(PLA_(2))is a critical biomarker of many diseases.Among various fluorescent probes,the ratiometric ones have shown great promise because they can provide built-in calibration to avoid interference f...
关键词：Biomimetic membrane Ratiometric nanoprobe Energy transfer Phospholipase A_(2) 
基于迈克尔加成反应的沙门氏菌纳米荧光标记研究被引量：1
《化学通报》2020年第2期127-131,155,I0001,共7页邢婕华 尹婷 罗英梅 肖乐 吕应年 蔡林涛 郑明彬 
国家自然科学基金项目(31571013);广东省科技规划项目(2012B031800488,2013B021900002)资助
本文通过迈克尔加成反应的荧光标记法,成功构建了纳米荧光探针标记的沙门氏菌(YB1-INPs)。采用三(2-羧乙基)膦将沙门氏菌YB1外膜蛋白表面上的二硫键温和还原为巯基后,与吲哚菁绿(ICG)@纳米探针(INPs)的马来酰亚胺基团(Mal)交联形成YB1-I...
关键词：沙门氏菌YB1 纳米探针 荧光标记 二硫键 温和还原 
Revealing the inhomogeneous surface chemistry on the spherical layered oxide polycrystalline cathode particles
《Chinese Physics B》2020年第2期81-86,共6页Zhi-Sen Jiang Shao-Feng Li Zheng-Rui Xu Dennis Nordlund Hendrik Ohldag Piero Pianetta Jun-Sik Lee Feng Lin Yi-Jin Liu 
Project supported by U.S.Department of Energy,Office of Science,Office of Basic Energy Sciences under Contract No.DE-AC02-76SF00515;National Science Foundation under Grant No.DMR-1832613.
The hierarchical structure of the composite cathodes brings in significant chemical complexity related to the interfaces,such as cathode electrolyte interphase.These interfaces account for only a small fraction of the...
关键词：Ni-rich CATHODE x-ray NANOPROBE redox heterogeneity surface chemistry 
Controllable Synthesis of Fluorescent Carbon Dots and Their Detection Application as Nanoprobes被引量：13
《Nano-Micro Letters》2013年第4期247-259,共13页Zhi Yang Zhaohui Li Minghan Xu Yujie Ma Jing Zhang Yanjie Su Feng Gao Hao Wei Liying Zhang 
supported by the National HighTech R&D Program of China (863 program, 2011AA050504);National Natural Science Foundation of China (21171117 and 61376003);Program for New Century Excellent Talents in University (NCET-12-0356);Shanghai Natural Science Foundation (13ZR1456600);Shanghai Science and Technology Grant (12JC1405700);Shanghai Pujiang Program (11PJD011);the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and Medical-Engineering Crossover Fund (YG2012MS40 and YG2012MS32) of Shanghai Jiao Tong University
Carbon dots(CDs), as a new member of carbon nanomaterial family, have aroused great interest since their discovery in 2004. Because of their outstanding water solubility, high sensitivity and selectivity to target ana...
关键词：Carbon dots HYDROTHERMAL SOLVOTHERMAL Microwave NANOPROBE 
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