Traditionally, we know that genomic DNA will produce transcripts named messenger RNA and then translate into protein following the instruction of genetic central dogma, and RNA works here as a pass-by messenger. Now i...
Induction and mobilization of transposable elements (TEs) following DNA damage or other stresses has been reported in prokaryotes and eukaryotes. Recently it was discovered that eukaryotic TEs are frequently associa...
Supported by A grant from the NIH/NHLBI,No.HL117199;Institutional funds from the Carolinas Health Care Foundation and Carolinas Medical Center
Hepatitis C virus(HCV)infection is one of main causes of hepatocellular carcinoma(HCC)and the prevalence of HCV-associated HCC is on the rise worldwide.It is particularly important and helpful to identify potential ma...
the National Natural Science Foundation of China[81573434 to BZC];Heilongjiang Touyan Innovation Team Program[BZC],HMU Marshal Initiative Funding(HMUMIF-21018 to BZC);National Nature Science Youth Foudation of China[82000226 to XFG].
Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during differentiation.Long non-coding RNAs(lncRNAs)exert critical epigenetic regulatory fun...
National Natural Sciences Foundation of China(81971408,81801469,81801468,and 81971411);National Key R&D Program of China(2016YFC1000403);2020"Diligence·Excellence"Clinical Innovative Team Project"Study on the comprehensive management of preeclampsia and its pathogenesis"conducted by Obstetrics and Gynecology Hospital of Fudan University(2021fckbc06)
Objective:Long non-coding RNAs(lncRNAs)are implicated in multiple pathophysiological processes in placenta-related disorders;however,their expression and function in late-onset pre-eclampsia(LOPE)remain unclear.This s...
BACKGROUND: The majority of mammalian genomes have been found to be transcribed into non-coding RNAs. One category of non-coding RNAs is classified as long non-coding RNAs (lncRNAs) based on their transcript sizes ...
National Natural Science Foundation of China(Grant No.3207040249).
As a pathological result of the abnormal differentiation of adipocytes,the occurrence of obesity will not only lead to weight gain,abnormal energy metabolism,but also the development of the diseases such as diabetes.E...
Recent deep sequencing surveys of mammalian genomes have unexpectedly revealed pervasive and complex transcription and identified tens of thousands of RNA transcripts that do not code for proteins. These non-coding RN...
supported by the Natural Science Foundation of Zhejiang Province(LZ22C170003);the Zhejiang Provincial Key R&D Program of China(2021C02008);the Fundamental Research Funds for the Central University(226-2022-00113),and the“Hundred Talents Program”funding from Zhejiang University to TZS.
Pork is one of the main meats consumed by people,and its nutritional value is closely related to human health.The lipid deposition and composition of pork not only affect the sensory quality but also determine the nut...
LncRNAs are defined as RNA transcripts greater than 200 nucleotides in length that have no or limited protein-coding potential.Basal expression of lncRNAs appeared important for various homeostatic processes,like gene...