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Relationship between hemoglobin glycation index and risk of hypoglycemia in type 2 diabetes with time-in-range in target
《World Journal of Diabetes》2024年第10期2058-2069,共12页Bei-Si Lin Zhi-Gu Liu Dan-Rui Chen Yan-Ling Yang Dai-Zhi Yang Jin-Hua Yan Long-Yi Zeng Xu-Bin Yang Wen Xu 
Supported by Investigator-initiated Trial Research Funds from Eli Lilly and Co.and Amylin Pharmaceuticals,Inc.,No.A1570;Natural Science Foundation of Guangdong Province,No.2018A030313915。
BACKGROUND In patients with type 2 diabetes mellitus(T2DM),the risk of hypoglycemia also occurs in at a time-in-range(TIR)of>70%.The hemoglobin glycation index(HGI)is considered the best single factor for predicting h...
关键词：Hemoglobin glycation index HYPOGLYCEMIA Type 2 diabetes mellitus Continuous glucose monitoring Time in range 
Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus
《World Journal of Clinical Cases》2024年第3期525-537,共13页Dharmsheel Shrivastav Desh Deepak Singh 
BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose utilization.Uncontrolled high sugar levels lead to advanced glycation end products(AGEs),which affects several metabolic pathways by ...
关键词：Type 2 diabetes mellitus MICRORNAS Advanced glycation end products Receptor for advanced glycation end products 
葡萄糖接枝对大豆分离蛋白功能特性和结构的影响被引量：12
《河南工业大学学报（自然科学版）》2018年第2期58-64,71,共8页左颖昕 布冠好 
国家自然科学基金项目(31201293);河南省教育厅科学技术研究重点项目(14B550013);河南工业大学省属高校基本科研业务费专项(2015RCJH02)
大豆分离蛋白的功能性质易受加工条件的影响,为改善其功能性质,采用糖基化方法进行改性。以大豆分离蛋白(SPI)和葡萄糖为原料,采用干热法在不同底物质量比、温度及反应时间下进行美拉德反应。结果表明:在反应温度为55℃,大豆分离蛋白与...
关键词：糖基化 大豆分离蛋白 葡萄糖 功能特性 结构特性 
Pitavastatin attenuates AGEs-induced mitophagy via inhibition of ROS generation in the mitochondria of cardiomyocytes被引量：7
《The Journal of Biomedical Research》2018年第4期281-287,共7页Zhimin Zha Junhong Wang Shiling Li Yan Guo 
supported by the National NaturalScience Foundation of China(NSFC 81570328,Wang Junhong);the"Sixth-Peak Talent"of Jiangsu Province(2011WSN-029 to Prof.Guo Yan and2013WSN-036 to Dr.Wang Junhong);support by the Health Department of Jiangsu Province(z201301)
This study aimed to investigate whether pitavastatin protected against injury induced by advanced glycation end products products（AGEs） in neonatal rat cardiomyocytes,and to examine the underlying mechanisms.Cardiom...
关键词：advanced glycation end products（AGEs） receptor for advanced glycation end products（RAGE） PITAVASTATIN autophagy mitochondrial oxidation oxidative stress 
糖化β-淀粉样蛋白对阿尔茨海默病样大鼠认知功能的影响被引量：1
《新乡医学院学报》2019年第6期511-516,共6页夏天光 刁云锋 毕莹 张健 陈江龙 董化江 董月青 
国家自然科学基金资助项目(编号:81471275,81771352,81671222,81771350);天津市自然科学基金资助项目(编号:16JCYBJC27600)
目的探讨糖化β-淀粉样蛋白(Aβ-AGE)对阿尔茨海默病样大鼠认知功能的影响。方法将β-淀粉样蛋白(Aβ)与甲基乙二醛于37℃下温育1个月合成Aβ-AGE。将40只SpragueDawley大鼠随机分为Aβ组、Aβ+小鼠单克隆高级糖化终产物受体抗体(Anti-R...
关键词：阿尔兹海默病 Β-淀粉样蛋白 糖基化 晚期糖基化终产物受体 
超声协同糖基化对蛋清粉致敏性及结构的影响被引量：5
《食品与机械》2018年第5期1-5,26,共6页宋启东 涂宗财 王辉 杨文华 刘光宪 陆建伟 
国家大宗淡水鱼产业技术体系项目(编号:CARS-45);江西省自然科学基金项目(编号:20142BAB213016)
以市售蛋清粉为研究对象,通过电泳、紫外光谱、荧光光谱和酶联免疫吸附等方法研究超声波协同糖基化修饰对其蛋白结构和致敏性的影响。结果表明,超声波协同糖基化修饰能显著降低蛋清粉的致敏性,致敏性随超声强度的增加呈先增加后降低的趋...
关键词：超声波 糖基化 致敏性 结构 蛋清粉 
Traditional Chinese Medicine
《China Medical Abstracts(Internal Medicine)》2012年第3期134-139,共6页
关键词：HIPPO SMAD EMODIN STASIS EXTRACTS mitochondrial EMBRYO inhibiting glycation regula 
Receptor of advanced glycation end-products axis and gallbladder cancer:A forgotten connection that we should reconsider
《World Journal of Gastroenterology》2022年第39期5679-5690,共12页Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez Miguel Angel Morales 
Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms,including gallbladder cancer.In this regard,data de...
关键词：Gallbladder cancer Advanced glycation end-products Receptor of advanced glycation end-products Chronic inflammation NUTRITION 
Deciphering the Hidden Secrets between the Early Skin Wrinkling & the Metabolic (X) Syndrome with the Possible Reversal of This Process at the Molecular Level
《Journal of Cosmetics, Dermatological Sciences and Applications》2024年第1期45-68,共24页Dalal Alsaadoun 
The aging process is a group of degenerative changes that physiologically occur in most of the people in the elderly. This affects one or more of the human body systems. The treatment of diseases related to the aging ...
关键词：COLLAGEN Skin Wrinkling Glycation Hyper-Insulinemia Hidden Obesity Vis-ceral Fat Inflammatory Cytokines 
MK615 decreases RAGE expression and inhibits TAGE-induced proliferation in hepatocellular carcinoma cells被引量：6
《World Journal of Gastroenterology》2010年第42期5334-5341,共8页Yuhki Sakuraoka Tokihiko Sawada Toshie Okada Takayuki Shiraki Yoshikazu Miura Katsuya Hiraishi Tatsushi Ohsawa Masakazu Adachi Jun-ichi Takino Masayoshi Takeuchi Keiichi Kubota 
Supported by A Research Grant from the Biomarker Society
AIM:To investigate the proliferative effect of advanced glycation end-products(AGEs) and the role of their cellular receptor(RAGE) on hepatocellular carcinoma(HCC) cells,and the inhibitory effects of MK615,an extract ...
关键词：Hepatocellular carcinoma Receptor of advanced glycation end-product Advanced glycation endproducts MK615 Toxic advanced glycation end-products 
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