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Incidence rate of prostate cancer in men treated for erectile dysfunction with phosphodiesterase type 5 inhibitors： retrospective analysis被引量：2
《Asian Journal of Andrology》2013年第2期246-248,I0008,共4页Anthony H Chavez K Scott Coffield M Hasan Rajab Chanhee Joe 
The purpose of this study was to determine the incidence rate of prostate cancer among men with erectile dysfunction （ED） treated with phosphodiesterase type 5 inhibitors （PDE-5i） over a 7-year period vs. men with...
关键词：erectile dysfunction （ED） phosphodiesterase 5 inhibitors （PDE-5i） prostate cancer prostatic neoplasms 
抑制剂对不育系岗46及F_1种子萌发中淀粉酶活性的分析被引量：3
《西南农业大学学报（自然科学版）》1999年第2期149-153,共5页廖宇静 周清元 张毅 沈福成 马志刚 张铜义 向立群 张晓军 
抑制剂Ａ与Ｂ分别设４种浓度，对水稻进行了浸种发芽试验。结果表明，抑制剂Ａ能使种子萌动，但不能生长；抑制剂Ｂ能抑制种子完全不萌动。但一旦去抑制以后，则不能再抑制种子的生长。用３．５－二硝基水扬酸法测定酶活性表明，抑制剂...
关键词：抑制剂 水稻 淀粉酶 种子萌发 穗发芽 酶活性 岗46不育系 
Experimental and modeling study of kinetics for methane hydrate formation in a crude oil-in-water emulsion被引量：2
《Petroleum Science》2016年第3期489-495,共7页Shranish Kar Himangshu Kakati Ajay Mandal Sukumar Laik 
the financial assistance provided by University Grants Commission, New Delhi, India, under Special Assistance Program (SAP) to the Department of Petroleum Engineering, Indian School of Mines, Dhanbad, India
A low-viscosity emulsion of crude oil in water can be believed to be the bulk of a flow regime in a pipeline.To differentiate which crude oil would and which would not counter the blockage of flow due to gas hydrate f...
关键词：Methane gas hydrates Organic inhibitors Chemical affinity model Normalized rate constant Asphaltenes 
New era of electrochemotherapy in treatment of liver tumors in conjunction with immunotherapies
《World Journal of Gastroenterology》2021年第48期8216-8226,共11页BlažTrotovšek Mihajlo Djokić MajaČemažar Gregor Serša 
Supported by the Slovenian Research Agency (ARRS)(P3-0003);cofinanced by the Republic of Slovenia and the European Regional Development Fund (Project Smart Gene.Si)。
Electrochemotherapy is a local ablative therapy that increases the cytotoxicity of either bleomycin or cisplatin by applying electric pulses(electroporation)to tumors.It has already been widely used throughout Europe ...
关键词：ELECTROPORATION ELECTROCHEMOTHERAPY Gene therapy Gene electrotransfer INTERLEUKIN-12 Immune checkpoint inhibitors Hepatocellular carcinoma 
基于分子对接、分子动力学模拟虚拟筛选中药来源的醛脱氢酶1A1抑制剂被引量：1
《中国现代药物应用》2022年第24期183-190,共8页吴辉渊 邓兰 李芬芬 
江西省卫生健康委科技计划(项目编号:202210810)。
目的基于分子对接、分子动力学模拟技术从中药化合物库中筛选醛脱氢酶1A1(ALDH1A1)抑制剂。方法运用计算机虚拟技术,进行分子对接、类药性、药动学、分子动力学模拟的筛选流程,从中药化学物库中筛选ALDH1A1抑制剂。结果血竭素表现出良好...
关键词：分子对接 分子动力学模拟 醛脱氢酶1A1 抑制剂 血竭素 
Agtr1a调节LPS诱导的Lbp^(-/-)小鼠原代肝细胞炎症被引量：1
《中国实验动物学报》2023年第8期1021-1027,共7页米传靓 付彬 李思迪 陈志达 郭中坤 张振宇 王可洲 
山东省医学科学院医药卫生科技创新工程,济南市科技局“高校20条”(2021GXRC011);山东省医药卫生科技发展计划(2019WS177);山东省生猪产业技术体系(SDAIT-08-17)。
目的基于LBP敲除小鼠(Lbp^(-/-))原代肝细胞探讨LBP缺失后Agtr1a调节LPS诱导炎症的作用。方法通过两步灌流法提取WT组、Lbp^(-/-)组小鼠原代肝细胞,构建LPS诱导的原代肝细胞炎症模型;分别采取加入抑制剂氯沙坦、转染siRNA两种方法抑制Lb...
关键词：血管紧张素受体1a Lbp^(-/-)小鼠 原代肝细胞 抑制剂 干扰RNA 细胞外信号调节激酶/磷酸化细胞外信号调节激酶 
Combination therapy using low‐dose anlotinib and immune checkpoint inhibitors for extensive‐stage small cell lung cancer
《Cancer Innovation》2024年第6期76-85,共10页Han Li Shumin Yuan Han Wu Yajie Wang Yichen Ma Xiance Tang Xiaomin Fu Lingdi Zhao Benling Xu Tiepeng Li Peng Qin Hongqin You Lu Han Zibing Wang 
National Natural Science Foundation of China,Grant/Award Number:81972690;Medical Science and Technology Research Project of Health Commission of Henan Province,Grant/Award Number:YXKC2021007。
Background:This study evaluated the efficacy and safety of low‐dose anlotinib combined with immune checkpoint inhibitors as second‐line or later treatment for extensive‐stage small cell lung cancer(ES‐SCLC).Method...
关键词：combination immunotherapy extensive‐stage small cell lung cancer immune checkpoint inhibitors low‐dose antiangiogenic drugs 
Systemic chemotherapy improves outcome of hepatocellular carcinoma patients treated with transarterial chemoembolization
《Hepatobiliary & Pancreatic Diseases International》2025年第2期157-163,共7页Wei-Chen Zhang Ke-Yi Du Song-Feng Yu Xue-E Guo Han-Xi Yu Dong-Yan Wu Cheng Pan Cheng Zhang Jian Wu Li-Fang Bian Lin-Ping Cao Jun Yu 
supported by grants from the National Natural Science Foundation of China(82270682);the Natural Science Foundation of Zhejiang Province(LQ21H030007 and LQ20H30006)。
Background:Transarterial chemoembolization(TACE)based neoadjuvant therapy was proven effective in hepatocellular carcinoma(HCC).Recently,tyrosine kinase inhibitors(TKIs)and immune checkpoint inhibitors(ICIs)also showe...
关键词：Neoadjuvant therapy Hepatocellular carcinoma Major pathologic response Transarterial chemoembolization Tyrosine kinase inhibitors Immune checkpoint inhibitors 
Synthesis of Triazole-Linked Amino Acid-Aryl C-Glycoside Hybrids via Click Chemistry as Novel PTPIB Inhibitors
《Chinese Journal of Chemistry》2011年第6期1227-1232,共6页Wang, Jia He, Xiaopeng Gao, Lixin Sheng, Li Shi, Xiaoxin Li, Jia Chen, Guorong 
Triazolyl phenylalanine and tyrosine-aryl C-glycoside hybrids were readily synthesized via microwave-assisted Cu（I）-catalyzed azide-alkyne 1,3-dipolar cycloaddition in high yields. Successive enzymatic assay identif...
关键词：click chemistry C-GLYCOSIDE triazolyl amino acid PTP INHIBITORS 
Synthesis of Vildagliptin-β-<i>O</i>-Glucuronide
《Advances in Chemical Engineering and Science》2012年第3期379-383,共5页Yansong Jack Lu Yugang Liu Mahavir Prashad Wen-Chung Shieh 
A linear 7-step synthesis of vildagliptin-β-O-glucuronide (2) starting from commercially available D-glucurono-6, 3-lactone (3) was herein achieved with 11.3% overall yield. Efficient preparation of compound 6 in pu...
关键词：VILDAGLIPTIN O-GLYCOSYLATION DPP-4 Inhibitors Type-2 Diabetes 
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