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检索条件："关键词=neuroprotective "
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脑缺血/再灌注损伤对小鼠海马区胶质细胞的影响被引量：2
《新疆医科大学学报》2012年第2期158-162,共5页沙晶 朱沂 党辉 补娟 景燕 艾山江.玉素甫江 李健 陆明佳 
国家自然科学基金(81060104)
目的探讨小鼠脑缺血/再灌注后胶质细胞形态学与数量的变化及其临床意义。方法采用随机方法将32只健康昆明雄性小鼠分为假手术组和模型组,每组16只。制备脑缺血/再灌注损伤模型,应用免疫组织化学方法分别标记星形胶质细胞特异性蛋白胶质...
关键词：脑缺血/再灌注损伤模型 胶质细胞 神经血管单元 神经保护作用 
Early rehabilitation and neuroprotective drug therapy outcomes in elderly patients with acute stroke
《Neural Regeneration Research》2011年第11期876-880,共5页Yue Chen Lufang Chen Yiqing Tao Feixue Zhou Chunlan Cui Shichao Liu 
the Science and Technology Foundation of Shanghai Railway Bureau of China, No. B340406052
Sixty elderly patients, viro cluffered from acute stroke and were admitted within a 1-year period to the Department of Geriatrics in the First Affiliated Hospital of School of Medicine, Zhejiang University, China, und...
关键词：acute stroke early rehabilitation neuroprotective therapy cognitive impairment prognosis evaluation 
石斛生物碱类成分药理活性及其作用机制研究进展被引量：8
《中国食物与营养》2023年第4期40-47,共8页梁艳田 刘佳萌 鲁为 范蓓 王凤忠 
中国农业科学院农产品加工研究所创新工程(项目编号:125161015000150013)
目的:总结石斛生物碱类成分如石斛总生物碱、石斛碱、石斛宁等药理活性及其作用机制的研究现状,为石斛的合理开发和临床应用提供科学依据。方法:检索近10年中国知网CNKI数据库及PubMed数据库中石斛生物碱类成分药理活性相关文献,根据活...
关键词：生物碱 石斛碱 药理活性 神经保护 改善记忆 糖脂代谢 
Substance P and its tachykinin NK1 receptor: a novel neuroprotective target for Parkinson's disease被引量：3
《Neural Regeneration Research》2015年第9期1403-1405,共3页Emma Thornton Robert Vink 
in part has been supported by the Neurosurgical Research Foundation, South Australia, Australia
Parkinson＇s disease （PD） is the most common motor neurode- generative disorder affecting approximately 4 million people worldwide. Although PD presents primarily with motor dysfunction, non-motor symptoms including...
关键词：NK a novel neuroprotective target for Parkinson’s disease Substance P and its tachykinin NK1 receptor 
Metabolic characterization of a potent natural neuroprotective agent dendrobine in vitro and in rats被引量：2
《Acta Pharmacologica Sinica》2022年第4期1059-1071,共13页Hong Pan Fu-guo Shi Chao Fang Jing-shan Shi 
This study was financially supported by the National Natural Science Foundation of China[U1812403];the Pharmacy National First-class Discipline Construction Project of Guizhou Province of China[GNYL(2017-006)].
Dendrobine is the main sesquiterpene alkaloid of Dendrobium nobile Lindl, which exhibits potent neuroprotective activity. However, its metabolism and disposition are little known. In this study, we investigated the me...
关键词：DENDROBINE neuroprotective agent drug metabolism cytochrome P450 metabolic stability UPLC-Q/Orbitrap MS 
Design,synthesis and neuroprotective effects of Fenazinel derivatives
《Chinese Chemical Letters》2017年第7期1505-1508,共4页Qing-Wei Zhang Ling Jiang Guan Wang Jian-Qi Li 
financially supported by Science and Technology Commission of Shanghai Municipality(Nos.14YF1412800,14431901600);by the National Natural Science Foundation of China(No.81273373)
In search of novel neuroprotective agents with higher potency and lower h ERG liability, a series of novel Fenazinel derivatives were designed and synthesized, among which compounds 8m–o containing amide moiety exhib...
关键词：Fenazinel Synthesis hERG Neuroprotective Ischemic stroke 
藁本内酯神经保护作用的研究进展被引量：9
《天津药学》2022年第1期72-78,共7页武改丽 霍志鹏 王玉 何毅 
国家“重大新药创制”科技重大专项(No.2017ZX09301005)。
藁本内酯属于苯酞类成分之一,在中药当归、川芎等伞形科植物中含量较高,含量在1%左右,是主要活性成分之一。神经损伤疾病包括脑卒中、阿尔茨海默症、帕金森、亨廷顿病等,为患者家庭和社会带来了沉重的心理和经济负担。现代药理研究表明...
关键词：藁本内酯 神经保护 抗氧化 抗炎 抗凋亡 改善血脑屏障通透性 神经元功能 
Gentianine protects hippocampal neurons in a rat model of recurrent febrile convulsion被引量：1
《Neural Regeneration Research》2011年第15期1130-1135,共6页Xuewei Liu Shumin Liu Na Wang Fang Lu Min Cao 
the Key Project of Technology of Ministry of Education, No. 2007029
Gentianine has been shown to have a protective effect on hippocampal CA1 neurons in rats subjected to recurrent febrile convulsion（FC）.The present study sought to explore the possible mechanism of gentianine by intr...
关键词：febrile convulsion gentianine hippocampal neurons neuroprotective effect GLUTAMATE γ-aminobutyric acid neural regeneration 
Synthesis and Neuroprotective Activity of Novel C4, C7 Derivatives in Tetracycline Series被引量：4
《Journal of Chinese Pharmaceutical Sciences》2004年第3期217-220,共4页ZHOUZhan-yun WANGHong-tao WANGXiao-wei WNAGRui-ping DUYan-sheng LIUJun-yi 
NationalNaturalScienceFoundationofChina( 2 0 3 72 0 0 5 )
Since the discovery of the tetracycline in 1953, numerous natural andsemisynthelic tetracyclines have been reported with broad spectrum antibacterial activity .Doxycycline 1 and minocycline 2 are semisyn-thetic second...
关键词：dedimethylaminotetracycline analogs minocycline iodide neuroprotective effects reduction 
Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease被引量：22
《Neural Regeneration Research》2013年第12期1061-1070,共10页Guang-Biao Huang Tong Zhao Sushma Shrestha Muna Hong-Mei Jin Jong-Il Park Kyu-Sik Jo Bo-Hee Lee Soo-Wan Chae Sun-Young Kim Soo-Hyun Park Eun-Ock Park Eun-Kyung Choi Young-Chul Chung 
funded by Muju Tianma Native Local Industrial Center,Korea
Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide （Ap）-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blum...
关键词：neural regeneration neuroprotective effect Traditional Chinese medicine Gastrodia elata Blume Alzheimer＇s disease Morris water maze test choline acetyltransferase ACETYLCHOLINESTERASE grants-supported paper NEUROREGENERATION 
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