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Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice:Evaluation of a novel Parkinsonian mouse model
《Zoological Research》2025年第1期225-235,共11页Xi-Zhen Ma Guo-Rui Jia Meng-Yu Li Sheng-Han Zhang Zhao-Xin Wang Ning Song Ying-Juan Liu Jun-Xia Xie 
supported by the National Natural Science Foundation of China (32471049,32170984,32471188,32200802);Natural Science Foundation of Shandong Province (ZR2023QH110)。
Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease(PD),supporting the“body-first”hypothesis.However,there remains a notable absence of PD-specific ani...
关键词：Parkinson’s disease Mouse model CXCL1 Inflammation PPAR signaling pathway 
既有线电气化改造防雷接地施工质量控制被引量：2
《铁路技术创新》2022年第2期52-57,共6页陈星翰 
在既有线电气化改造过程中,为有效防止对地电位、直击雷、雷电磁脉冲、感应雷等对四电设备产生危害,从铁路综合防雷接地系统的关键施工内容进行论述,深入分析防雷接地施工的把控要点,提出了各项防雷接地施工的质量控制措施。通过不断推...
关键词：电气化改造 四电 综合防雷接地系统 质量控制 
8b／10b编码实现LVDS交流耦合传输中的直流平衡被引量：11
《科学技术与工程》2012年第35期9693-9696,9701,共5页刘泳锐 张彦军 刘龙飞 雷建胜 
国家自然科学基金(51075375)资助
LVDS在高速数据传输中得到了广泛应用,但在传输过程中存在交流耦合,使得连续出现的0或1信号传输会出现丢数、误码等问题。通过介绍直流平衡在交流耦合中的作用,采用8b/10b编码的方法,实现了直流平衡。同时说明了8b/10b编码的具体实现过...
关键词：低压差分信号(Low VOLTAGE DIFFERENTIAL SIGNALING LVDS)8b 10b 交流耦合 直流平衡 
Protective effect of Shouwu Yizhi decoction against vascular dementia by promoting angiogenesis被引量：13
《Chinese Journal of Natural Medicines》2017年第10期740-750,共11页YANG Xiao-Ni LI Chang-Sheng CHEN Chao TANG Xiao-Yong CHENG Guang-Qing LI Xia 
supported by the National Natural Science Foundation of China(Nos.81302940,81373670 and 30873323);the Natural Science Foundation of Shandong Province(ZR2015PH046,Y2005C43);Science and Technology Development Grant of the State Administration of TCM of Shandong(2011-192,2015-286,2013-216);Family Planning Committee of Shandong Province([2014]14);the Primary Research&Development Plan of Shandong Province(2016GSF202016);the Innovation Project of Shandong Academy of Medical Sciences
Shouwu is a traditional Chinese medicine(TCM)with neuroprotective effect.Shouwu Yizhi decoction(SYD)was designed based on TCM theory.However,little is known about the roles of SYD in Vascular dementia(Va D).The presen...
关键词：Shouwu Yizhi DECOCTION VASCULAR DEMENTIA ANGIOGENESIS VEGF-Notch signaling pathway 
白介素1β激活信号传导与转录因子3促肿瘤发生的机制研究进展被引量：10
《标记免疫分析与临床》2020年第11期2011-2015,共5页龙江文 向延根 马小华 胡锦跃 刘姝灵 
国家自然科学基金面上项目(编号:81172042)。
炎性细胞和介质是构成肿瘤微环境的主要部分,并在癌症的发生、肿瘤细胞的增殖和转移中起重要作用,白细胞介素1β(IL-1β)作为IL-1家族成员是一类重要的炎性细胞因子,能介导肿瘤的增殖、侵袭及转移,在肿瘤的发生中扮演重要角色。信号传...
关键词：白细胞介素1Β 信号传导与转录激活因子3 信号通路 肿瘤 
A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models被引量：1
《Acta Pharmaceutica Sinica B》2022年第2期774-786,共13页Ming Ji Dongjie Wang Songwen Lin Chunyang Wang Ling Li Zhihui Zhang Jing Jin Deyu Wu Yi Dong Heng Xu Duo Lu Xiaoguang Chen 
supported by the CAMS Innovation Fund(2016I2M-3-008,China);The Drug Innovation Major Project(2018ZX09711001-003-011 and 2018ZX09711001-005-017,China);the Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences(Grant 2018PT35003,China)。
Glioblastoma is carcinogenesis of glial cells in central nervous system and has the highest incidence among primary brain tumors.Brain metastasis,such as breast cancer and lung cancer,also leads to high mortality.The ...
关键词：GLIOBLASTOMA Brain metastasis PI3K-mTOR-AKT signaling pathway PI3K inhibitor IL-17A 
Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction被引量：1
《World Journal of Stem Cells》2024年第4期444-458,共15页Cheng-Jin Ai Ling-Juan Chen Li-Xuan Guo Ya-Ping Wang Zi-Yi Zhao 
BACKGROUND Leukemia stem cells(LSCs)are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia(AML),as they are protected by the bone marrow microenvironment(BMM)against...
关键词：Leukemia stem cells Gossypol acetic acid Reactive oxygen species Mitochondrial dysfunction Interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling 
Low-cost binding update scheme based on pointer forwarding in HMIPv6 network
《The Journal of China Universities of Posts and Telecommunications》2010年第3期73-77,共5页LIU Yin-long ZENG Zhi-min XIA Hai-lun ZHANG Tian-kui HAO Xiao-yan 
supported by the Natural Science Foundation of Jiangsu Province (BK2009469);the Fundamental Research Funds for the Central Universities (BUPT2009RC0120);the National Natural Science Foundation of China (60772110)
By introducing a mobility anchor point （MAP）, hierarchical mobile IPv6 （HMIPv6） reduces the binding update signaling cost associated with mobile IPv6, but there still exist deficiencies. For instance, a mobile no...
关键词：hierarchical MIPv6 binding update pointer forwarding signaling cost 
Emerging Roles of Sphingolipid Signaling in Plant Response to Biotic and Abiotic Stresses被引量：7
《Molecular Plant》2018年第11期1328-1343,共16页Usman Ali Hehuan Li Xuemin Wang Liang Guo 
the National Natural Science Foundation of China (31570808);the Fundamental Research Funds for the Central Universities (2662015PY090).
Plant sphingolipids are not only structural components of the plasma membrane and other endomembrane systems but also act as signaling molecules during biotic and abiotic stresses.However,the roles of sphingolipids in...
关键词：SPHINGOLIPIDS LONG-CHAIN bases SPHINGOLIPID signaling biotic STRESS ABIOTIC STRESS 
NPR1-dependent salicylic acid signaling inhibits Agrobacteriummediated transient expression in Arabidopsis被引量：3
《Science China(Life Sciences)》2017年第6期668-670,共3页Wenliu Zhu Xiaotong Hu Chongyang Wang Shunping Yan 
supported by the Thousand Talents Plan-Young Professionals from China,Huazhong Agricultural University Scientific&Technological Self-innovation Foundation(2014RC004);the Fundamental Research Funds for the Central Universities(2662015PY064)
Dear Editor,Arabidopsis thaliana,as a model plant,is the most well-studied plant species.One of the advantages of using Arabidopsis is that obtaining stably transformed plants using flower-dipping method is easy.Howev...
关键词：Arabidopsis consuming salicylic Agrobacterium transfection transformed flower transgenic signaling generating 
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