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Bear bile powder alleviates Parkinson’s disease-like behavior in mice by inhibiting astrocyte-mediated neuroinflammation被引量：2
《Chinese Journal of Natural Medicines》2023年第9期710-720,共11页WANG Lupeng BAI Yuyan TAO Yanlin SHEN Wei ZHOU Houyuan HE Yixin WU Hui HUANG Fei SHI Hailian WU Xiaojun 
the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(No.2023YZZ02).
Parkinson’s disease(PD)is a common neurodegenerative disease in middle-aged and elderly people.In particular,increasing evidence has showed that astrocyte-mediated neuroinflammation is involved in the pathogenesis of...
关键词：Parkinson's disease Bear bile powder ASTROCYTE NEUROINFLAMMATION Takeda G protein-coupled receptor 5 
武田(TAKEDA)
《电脑采购》2002年第7期30-30,共1页
近来欧美游戏界刮起了一阵日本风,与日本文化背景有关的游戏层出不穷,《幕府将军》、《暗黑武士》、《魔域帝国》一个接一个的被摆上了货架,虽然在我们看来这些游戏多少显得有些不伦不类,但对于欧美玩家来说,也许会兴趣百倍也不一定。...
关键词：武田信玄 日本文化 战国时期 群雄割据 军阀混战 TAKEDA 生平事迹 进入战斗 乱作一团 战争场面 
Bile acids and metabolic surgery
《Liver Research》2021年第3期164-170,共7页Hui Xue Luyao Huang Jui Tu Lili Ding Wendong Huang 
This work was supported by the National Natural Science Foundation of China(81773961)to L.Ding,along with grants from John Hench foundation,George Schaeffer foundation and National Institute of Diabetes and Digestive and Kidney Diseases(R01DK124627)to W.Huang.
The epidemic of obesity and its co-mortalities has reached an alarming level worldwide.Currently,metabolic surgeries,especially the Roux-en-Y gastric bypass and vertical sleeve gastrectomy,are the most effective and s...
关键词：Metabolic surgery OBESITY Type 2 diabetes(T2D) Non-alcoholic fatty liver disease(NAFLD) Bile acid Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) 
Altered serotonin metabolism in Takeda G protein-coupled receptor 5 knockout mice protects against diet-induced hepatic fibrosis
《Liver Research》2022年第4期214-226,共13页Jessica M.Ferrell Matthew Dilts Zachary Stahl Shannon Boehme Sabita Pokhrel Xinwen Wang John Y.L.Chiang 
This work was supported by the USA National Institutes of Health(NIH)(AA015951,DK044442,and DK058379).
Background and aims:Diet-induced obesity and metabolic syndrome can trigger the progression of fatty liver disease to non-alcoholic steatohepatitis and fibrosis,which is a major public health concern.Bile acids regula...
关键词：Non-alcoholic fatty liver disease(NAFLD) Liver fibrosis Takeda G protein-coupled receptor 5(TGR5) Serotonin(5-HT) High fat high fructose and high sucrose (HFS) 
Regulation of bile acid receptor activity被引量：9
《Liver Research》2018年第4期180-185,共6页Yu-Jui Yvonne Wan Lili Sheng 
This study was supported by grants funded by the USA National Institutes of Health(NIH)U01CA179582 and R01 CA222490.
Many receptors can be activated by bile acids(BAs)and their derivatives.These include nuclear receptors farnesoid X receptor(FXR),pregnane X receptor(PXR),and vitamin D receptor(VDR),as well as membrane receptors Take...
关键词：Bile acid receptor Farnesoid X receptor(FXR) G protein-coupled bile acid receptor Takeda G protein receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) ACETYLATION Methylation GLYCOSYLATION 
Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis被引量：18
《World Journal of Gastroenterology》2021年第24期3609-3629,共21页Zhen-Huan Yang Fang Liu Xiao-Ran Zhu Fei-Ya Suo Zi-jun Jia Shu-Kun Yao 
Supported by National Key Technology Support Program during“12th Five-Year Plan”Period of China,No.2014BAI08B00;National Key Research and Development Plan for Precision Medicine Research,No.2017YFC0910002;and Leapforward Development Program for Beijing Biopharmaceutical Industry(G20),No.Z171100001717008.
BACKGROUND Gut microbiota and its metabolites may be involved in the pathogenesis of inflammatory bowel disease.Several clinical studies have recently shown that patients with ulcerative colitis(UC)have altered profil...
关键词：Ulcerative colitis Gut microbiota Bile acids Takeda G-protein-coupled receptor 5 Vitamin D receptor 
Bile acid receptors and signaling crosstalk in the liver, gut and brain被引量：4
《Liver Research》2021年第3期105-118,共14页Jessica M.Ferrell John Y.L.Chiang 
This work was supported by the USA National Institutes of Health AA015951 to J.M.Ferrell,and DK44442 and DK58379 to J.Y.L.Chiang.
Bile acids are physiological detergents derived from cholesterol that aid in digestion and nutrient ab-sorption,and they play roles in glucose,lipid,and energy metabolism and in gut microbiome and metabolic homeostasi...
关键词：Bile acid metabolism Farnesoid X receptor(FXR) Gut-brain axis MICROBIOME Neurodegenerative disease Takeda G protein-coupled receptor(TGR5) 
激活TGR5缓解肾缺血再灌注后肾脏纤维化损伤
《中山大学学报（医学科学版）》2023年第4期617-624,共8页李蒙 隆罗莎 梁柏恩 徐龙 赵晓朵 王蔚东 李春凌 
国家自然科学基金(81870465,82270744);广东省自然科学基金(2021A1515011482)。
【目的】探讨激活胆汁酸受体TGR5在单肾缺血再灌注损伤合并对侧肾摘除(uIRIx)模型诱导的肾脏纤维化中的作用。【方法】体内实验:将C57BL/6J小鼠随机分成假手术(Sham)组、uIRIx组及uIRIx+石胆酸(LCA)组,每组6只,使用uIRIx模型诱导肾脏纤...
关键词：Takeda G蛋白耦联受体5 单肾缺血再灌注损伤合并对侧肾摘除 肾脏纤维化 石胆酸 
Bile acid receptors and gastrointestinal functions被引量：18
《Liver Research》2019年第1期31-39,共9页Alexander L.Ticho Pooja Malhotra Pradeep K.Dudeja Ravinder K.Gill Waddah A.Alrefai 
The work in the authors'laboratories was supported by merit review grants from the Department of Veterans Affairs,United States(VA):BX000152(W.A.Alrefai)and BX002011(P.K.Dudeja);F30 grant DK117535(A.L.Ticho);and R01 grants:DK109709(W.A.Alrefai),DK54016(P.K.Dudeja),DK81858(P.K.Dudeja),DK92441(P.K.Dudeja),DK98170(R.K.Gill),from the USA National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health,United States.
Bile acids modulate several gastrointestinal(GI)functions including electrolyte secretion and absorption,gastric emptying,and small intestinal and colonic motility.High concentrations of bile acids lead to diarrhea an...
关键词：Bile acids Nuclear receptors Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Gastrointestinal function 
The contributions of bacteria metabolites to the development of hepatic encephalopathy
《Liver Research》2023年第4期296-303,共8页Miranda Claire Gilbert Tahereh Setayesh Yu-Jui Yvonne Wan 
the USA National Institutes of Health(NIH)R01CA222490.
Over 20%of mortality during acute liver failure is associated with the development of hepatic encephalopathy(HE).Thus,HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities...
关键词：LIVER Gut-liver-brain axis Bile acids(BAs) Bile acid(BA)receptors Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) Brain 
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