超高压技术在蛋白质改性和活性肽制备中的应用研究进展  

Progress in the Application of Ultra-High Pressure Technology in Protein Modification and Bioactive Peptide Preparation

作　　者：陈梦婷 郑昌亮 汪兰[1] 孙智达[2] 谢笔钧[2] 石柳 丁安子[1] 熊光权[1] 乔宇[1] 李新[1] 吴文锦[1] CHEN Mengting;ZHENG Changliang;WANG Lan;SUN Zhida;XIE Bijun;SHI Liu;DING Anzi;XIONG Guangquan;QIAO Yu;LI Xin;WU Wenjin(Key Laboratory of Cold Chain Logistics Technology for Agro-product,Ministry of Agriculture and Rural Affairs,Institute of Agro-products Processing and Nuclear Agricultural Technology,Hubei Academy of Agricultural Sciences,Wuhan 430064,China;College of Food Science and Technology,Huazhong Agricultural University,Wuhan 430070,China)

机构地区：[1]湖北省农业科学院农产品加工与核农技术研究所,农业农村部农产品冷链物流技术重点实验室,湖北武汉430064 [2]华中农业大学食品科学技术学院,湖北武汉430070

出　　处：《食品科学》2023年第5期298-304,共7页Food Science

基　　金：“十三五”国家重点研发计划重点专项(2019YFD0901805)。

摘　　要：生物活性肽可以从植物、动物、海洋资源中获得,其具有多种生物活性,如抗高血压、抗氧化、抗血栓、降胆固醇、降血压、抗菌、免疫调节、细胞调节、结合矿物质等。提高蛋白质向多肽的转化率一直以来是多肽研究的难点之一,超高压技术是一种适合于规模化生产的新型非热加工物理技术,近年来被广泛地应用于蛋白质工程,超高压技术的应用改善了蛋白质的结构和功能特性,提高了生物活性肽提取、生产的效率。本文重点综述超高压技术在蛋白质改性和肽制备方面的应用,概述超高压制备生物活性肽的类型、来源和生物活性,以期为深入应用超高压技术辅助蛋白质改性和活性肽制备提供参考。Bioactive peptides can be obtained from plant,animal or marine sources.Bioactive peptides possess diverse biological activities such as antihypertension,antioxidant,antithrombosis,cholesterol-lowering,blood pressure-lowering,antibacterial,immune regulation,cell regulation,and mineral-binding properties.How to improve the conversion rate of proteins to peptides is always one of the difficulties in the research field of peptide.Ultra-high pressure technology is a novel non-thermal physical processing technology suitable for large-scale production,which has been widely used to the structural and functional characteristics of proteins,as well as the extraction and production efficiency of bioactive peptides.This review paper mainly focuses on the application of ultra-high pressure technology in protein modification and peptide preparation.The types,sources and biological activities of bioactive peptides prepared by ultra-high pressure technology are also summarized.

关 键 词：超高压技术 蛋白质改性 生物活性肽 

分 类 号：TS201.2[轻工技术与工程—食品科学]