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医药卫生: 作品数：15372335被引量：10125488H指数：549; 导出分析报告; 相关作者：王伟胡大一李静张伟李莉更多>>; 相关机构：复旦大学华中科技大学第二军医大学山东大学更多>>; 发文主题：护理疗效观察疗效临床疗效儿童更多>>; 相关期刊：更多>>; 发文基金：国家自然科学基金国家重点基础研究发展计划国家科技重大专项广东省自然科学基金更多>>

脐带间充质干细胞治疗多囊卵巢综合征的作用及机制被引量：1: 《中国组织工程研究》2024年第7期1015-1020,共6页刘麒薇张俊辉杨袁王金娟; 北京市自然科学基金资助项目(7214228),项目负责人:刘麒薇。; 背景:目前对多囊卵巢综合征的治疗大多是超指征用药,对其治疗仍面临很大的挑战。研究证明人脐带间充质干细胞可修复卵巢功能,但鲜有研究报道其对多囊卵巢综合征的治疗作用。目的:观察人脐带间充质干细胞对多囊卵巢综合征的治疗作用,并...; 关键词：脐带间充质干细胞多囊卵巢综合征排卵障碍内分泌紊乱线粒体自噬

1%富血小板血浆联合骨髓间充质干细胞促进周围神经损伤的修复: 《中国组织工程研究》2024年第7期985-992,共8页冯睿钦韩娜张蒙谷馨怡张丰识; 北京市自然科学基金(7222198),项目负责人:韩娜。; 背景:富血小板血浆已被证明能够增强间充质干细胞活性并具有促血管再生能力。细胞外囊泡是间充质干细胞发挥作用的关键介质之一,但目前还不清楚富血小板血浆是否能影响细胞外囊泡的功能。目的:探索富血小板血浆对骨髓间充质干细胞分泌...; 关键词：富血小板血浆间充质干细胞细胞外囊泡周围神经损伤施万细胞重编程神经导管间充质干细胞移植坐骨神经损伤

不同因素影响激素性股骨头坏死家兔模型成模效果的网状Meta分析被引量：1: 《中国组织工程研究》2024年第6期976-984,共9页胡智星李群杨超王潇潇方罗昌婷侯吴琼林娜陈卫衡刘春芳林雅; 国家自然科学基金重点项目(82030122),项目负责人:陈卫衡;国家自然科学基金面上项目(81973888),项目负责人:陈卫衡;北京市自然科学基金面上项目(7232304),项目负责人:刘春芳;中央级公益性科研院所基本科研业务费专项(ZXKT20013),项目负责人:刘春芳;中国中医科学院科技创新工程项目(C12021A03808),项目负责人:林娜。; 目的:激素性股骨头坏死家兔模型是最常用的股骨头坏死动物模型,其股骨头病理学改变与临床较为接近,但目前国内外报道的造模条件、方法和评价标准等均不统一,导致所建立动物模型的科学价值低、难于推广应用。此次研究旨在明确不同造模条...; 关键词：激素性股骨头坏死家兔动物模型造模方法影响因素亚组分析网状Meta分析循证医学

Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke被引量：6: 《Neural Regeneration Research》2024年第2期409-415,共7页Hongmei Duan Shulun Li Peng Hao Fei Hao Wen Zhao Yudan Gao Hui Qiao Yiming Gu Yang Lv Xinjie Bao Kin Chiu Kwok-Fai So Zhaoyang Yang Xiaoguang Li; supported by the National Natural Science Foundation of China,Nos.81941011(to XL),31771053(to HD),31730030(to XL),31971279(to ZY),31900749(to PH),31650001(to XL),31320103903(to XL),31670988(to ZY);the Natural Science Foundation of Beijing,Nos.7222004(to HD);a grant from Ministry of Science and Technology of China,Nos.2017YFC1104002(to ZY),2017YFC1104001(to XL);a grant from Beihang University,No.JKF-YG-22-B001(to FH)。; Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactiv...; 关键词：adult endogenous neurogenesis ANGIOGENESIS basic fibroblast growth factor-chitosan gel CHITOSAN functional recovery ischemic stroke neural stem cell newborn neuron

Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment被引量：2: 《Neural Regeneration Research》2024年第2期440-446,共7页Sumei Liu Baoguo Liu Qian Li Tianqi Zheng Bochao Liu Mo Li Zhiguo Chen; supported by the Stem Cell and Translation National Key Project,No.2016YFA0101403(to ZC);the National Natural Science Foundation of China,Nos.82171250 and 81973351(to ZC);the Natural Science Foundation of Beijing,No.5142005(to ZC);Beijing Talents Foundation,No.2017000021223TD03(to ZC);Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan,No.CIT&TCD20180333(to ZC);Beijing Municipal Health Commission Fund,No.PXM2020_026283_000005(to ZC);Beijing One Hundred,Thousand,and Ten Thousand Talents Fund,No.2018A03(to ZC);the Royal Society-Newton Advanced Fellowship,No.NA150482(to ZC);the National Natural Science Foundation of China for Young Scientists,No.31900740(to SL)。; Recent studies have mostly focused on engraftment of cells at the lesioned spinal cord,with the expectation that differentiated neurons facilitate recovery.Only a few studies have attempted to use transplanted cells a...; 关键词：biomaterial FIBRINOGEN functional recovery induced neural stem cell transplantation MICROENVIRONMENT MICROGLIA spinal cord injury THROMBIN

Advantages of nanocarriers for basic research in the field of traumatic brain injury被引量：2: 《Neural Regeneration Research》2024年第2期237-245,共9页Xingshuang Song Yizhi Zhang Ziyan Tang Lina Du; supported by the Natural Science Foundation of Beijing,No.L222126(to LD)。; A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researche...; 关键词：blood-brain barriers brain targeting central nervous system extracellular vesicles inflammatory factor microglial cell NANOCARRIERS nanoparticles neural restoration traumatic brain injury

重视基层卫生服务在儿童近视防控行为干预中的作用被引量：2: 《中国全科医学》2023年第33期4213-4217,共5页王婕李仕明魏士飞王宁利; 国家自然科学基金重大国际合作项目(81120108007);国家自然科学基金资助项目(82071000);北京市自然科学基金杰出青年科学基金(JQ20029);首都卫生发展科研专项(2020-2-1081)。; 近视是危害儿童视力健康的主要因素,规范化开展近视的筛查工作,实现近视的早发现、早干预是防控儿童近视发生和发展的重要措施。当前我国近视筛查、屈光发育档案建立和管理应用尚处于起步阶段,尤其是屈光档案建立后的后续跟进措施仍面...; 关键词：近视行为干预社区卫生服务中心三级预防分级诊疗公共卫生

Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example被引量：3: 《Journal of Pharmaceutical Analysis》2023年第5期535-543,共9页Wangmin Hu Junling Hou Wenjing Liu Xuan Gu Yulei Yang Hongcai Shang Mei Zhang; supported by Ministry of Science and Technology of the People's Republic of China(Grant No.:2022YFC3502300);Beijing Natural Science Foundation(Grant No.:L222150);the National Natural Science Foundation of China(Grant No.:82072247);the second batch of“Ten thousand plan”National High Level Talents Special Support Plan(Grant No.:W02020052);Beijing University of Chinese Medicine(Grant Nos.:XJYS21005,JY21024,MSGZF-202001,2022-syjs-05,and 2022-syjs-10).; The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,...; 关键词：Process analytical technology TCM Pharmaceuticals Miniature mass spectrometry Online analysis

基于系统动力学理念的基本医疗保险门诊按人头付费政策对医疗费用的影响机制:以浙江省嵊州市门诊支付方式改革为例被引量：4: 《中国全科医学》2023年第28期3496-3501,共6页王钰东马晓静王芳; 北京市自然科学基金青年项目(9214026);中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-046);国新健康保障服务集团股份有限公司委托项目。; 背景浙江省嵊州市自2022年8月起开展医疗保险门诊支付方式改革,通过实施总额预算、更新人头费测算标准、改进激励约束机制等政策逐步开展按人头付费改革,激励基层医疗卫生机构提供适宜的基本医疗服务,降低基层医疗费用支出,促进医疗保...; 关键词：按人头付费医疗保险支付方式改革医防融合系统动力学费用医疗

Multidrug dissolvable microneedle patch for the treatment of recurrent oral ulcer被引量：4: 《Bio-Design and Manufacturing》2023年第3期255-267,共13页Yuqiong Wang An’an Sheng Xinran Jiang Shanshan Yang Long Lin Mingzhu Yang Fengshuo Zhu Yongyan Hu Jian Li Lingqian Chang; the National Natural Science Foundation of China(Nos.62003023,32071407,52073138,52003018 and 52003019);Beijing Natural Science Foundation(No.7212204);Beijing Advanced Innovation Center for Biomedical Engineering and Beihang University.; Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work r...; 关键词：Recurrent oral ulcer Dissolvable microneedle Hyaluronic acid microneedle MULTIDRUG ANTI-INFLAMMATION Healing promoting effect

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