This investigation received support from the National Natural Science foundation of China (No 81072664 and 81373437) and the National Science and Technology Major Project of China (Grant No 2012ZX09301002-001-022-01).Shu-zhen CHEN designed the study and edited the paper; Fang LIU performed the research, analyzed the data and wrote the paper; and Yue SHANG performed the mouse experiments.
Aim: To assess the synergistic actions of lidamycin (LDM) and chloroquine (CQ), a lysosomal enzyme inhibitor, in human non-small cell lung cancer (NSCLC) cells, and to elucidate the potential mechanisms. Method...