云南高校图书馆联盟文献共享服务平台- 国家重点基础研究发展计划(2009CB940900)

国家重点基础研究发展计划(2009CB940900): 作品数：10被引量：64H指数：5; 导出分析报告; 相关作者：姚毅武蒋晟薛晓文姚和权更多>>; 相关机构：中国药科大学中国科学院广州生物医药与健康研究院更多>>; 相关期刊：《Natural Products and Bioprospecting》《中国新药杂志》《Acta Pharmacologica Sinica》《Science China Chemistry》更多>>; 相关主题：NEWIPSREPROGRAMMINGMELIACEAEGSK3Β更多>>; 相关领域：生物学理学医药卫生化学工程更多>>

Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell selfrenewal and somatic cell reprogramming被引量：8: 《Cell Research》2014年第9期1121-1136,共16页Guofang Chen Xinxiu Xu Lihong Zhang Yanbin Fu Min Wang Haifeng Gu Xin Xie; Maintaining the self-renewal of embryonic stem cells （ESCs） could be achieved by activating the extrinsic signaling, i.e., the use of leukemia inhibitory factor （LIF）, or blocking the intrinsic differentiation pat...; 关键词：SUNITINIB Sutent embryonic stem cell SELF-RENEWAL IPSC VEGF AUTOCRINE

Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors: 《Science China Chemistry》2014年第6期823-832,共10页ZOU DingBiao QIU YaTao TU ZhengChao LIAO ChenZhong LUO JinFeng MENG QingQing YAO RiSheng LI Zheng JIANG Sheng; supported by the National Natural Science Foundation of China(21172220);the National Basic Research Program of China(2009CB940900); We designed a series of 2-methylpyrimidine derivatives as new BCR-ABL inhibitors using scaffold-hopping strategy.These synthetic compounds exhibited significant inhibition against a broad spectrum of Bcr-Abl mutants i...; 关键词：chronic myeloid leukemia（CML） anticancer agents BCR-ABL imatinib resistance

iPSCs and small molecules： a reciprocal effort towards better approaches for drug discovery被引量：6: 《Acta Pharmacologica Sinica》2013年第6期765-776,共12页Ru ZHANG Li-hong ZHANG Xin XIE; The revolutionary induced pluripotent stem cell （iPSC） technology provides a new path for cell replacement therapies and drug screening. Patient-specific iPSCs and subsequent differentiated cells manifesting disease...; 关键词：induced pluripotent stem cells （iPSCs） disease modeling drug screening toxicity evaluation cell replacement therapy small molecules drug development

组蛋白去乙酰化酶抑制剂抗肿瘤临床研究进展被引量：15: 《中国新药杂志》2013年第3期294-300,共7页姚毅武姚和权蒋晟薛晓文; 国家自然科学基金(20972160;1172220);国家重点基础研究发展计划(973计划)(2009CB940900); 综述了近年来组蛋白去乙酰化酶(HDAC)抑制剂作为抗肿瘤药的临床研究进展。组蛋白去乙酰化酶抑制剂可以引导肿瘤细胞生长停滞、分化和凋亡,是很有前途的癌症治疗药物。目前,超过十多种组蛋白去乙酰化酶抑制剂作为治疗血液肿瘤和恶性实体...; 关键词：组蛋白去乙酰化酶组蛋白去乙酰化酶抑制剂抗肿瘤

Four New Indole Alkaloids from Neolamarckia cadamba: 《Chinese Journal of Chemistry》2013年第1期79-83,共5页Lingli Liu Shifei Li Qiang Zhang Feng Zhu Wei Yang Hongping He Xiaojiang Hao; Phytochemical investigation on the leaves ofNeolamarckia cadamba led to the isolation of four new indole al- kaloids, spirocadambine （1）, dehydraisodihydrocadambine （2）, nitrocadambines A and B （3 and 4）. The st...; 关键词：RUBIACEAE Neolamarckia cadamba indole alkaloids glucoalkaloids

Stress-mediated p38 activation promotes somatic cell reprogramming被引量：12: 《Cell Research》2013年第1期131-141,共11页Xinxiu Xu Quan Wang Yuan Long Ru Zhang Xiaoyuan Wei Mingzhe Xing Haifeng Gu Xin Xie; Environmental stress-mediated adaptation plays essential roles in the evolution of life. Cellular adaptation mechanisms usually involve the regulation of chromatin structure, transcription, mRNA stability and translat...; 关键词：induced pluripotent stem cells IPS hyperosmosis NACL STRESS P38 REPROGRAMMING

Two new tirucallane triterpenoids from Aphanamixis grandifolia被引量：5: 《Natural Products and Bioprospecting》2012年第5期222-226,共5页Xiao-Ying WANG Gui-Hua TANG Chun-Mao YUAN Yu ZHANG Li HOU Qing ZHAO Xiao-Jiang HAO Hong-Ping HE; This work was financially supported by grants from the National Basic Research Program of China(973 Program,2009CB522300 and 2009CB940900);National Natural Science Funding of China(31170332);the Young Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).; Two new tirucallane triterpenoids,2a-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid(1)and(23E)-2a-hydroxytirucalla-7,23,25-triene-3-one(2),along with the known 2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,2...; 关键词：Aphanamixis grandifolia MELIACEAE 2 3-seco-tirucallane triterpenoid BIOASSAYS

Five new mexicanolide type limonoids from Heynea trijuga被引量：2: 《Natural Products and Bioprospecting》2012年第4期145-149,共5页Wei YANG Ling-Mei KONG Shi-Fei LI Yan LI Yu ZHANG Hong-Ping HE Xiao-Jiang HAO; supported by grants from the National Basic Research Program of China(973 Program,2009CB522300 and 2009CB940900);National Natural Science Funding of China(31170332);the Young Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).; Five new mexicanolide-type limonoids,heytrijunolides A-E(1-5)were isolated from the branches and leaves of Heynea trijuga.The structures of these new compounds were elucidated on the basis of extensive spectroscopic a...; 关键词：Heynea trijuga MELIACEAE LIMONOIDS mexicanolide-type heytrijunolide

β-Carboline alkaloids from Trigonostemon filipes and Trigonostemon lii被引量：2: 《Natural Products and Bioprospecting》2012年第3期126-129,共4页Shi-Fei LI Yuan-Yuan CHENG Yu ZHANG Shun-Lin LI Hong-Ping HE Xiao-Jiang HAO; supported financially by the National Natural Science Foundation of China(30830114 and 21072199);the Ministry of Science and Technology of China(2009CB522300 and 2009CB940900);the Natural Science Fund of Yunnan Province(2009CD112);the Foundation of Chinese Academy of Sciences to H.P.He,the Yong Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).; Sixβ-carboline alkaloids including three new ones,trifilines A-C(1-3)were isolated from Trigonostemon filipes,along with a newβ-carboline alkaloid,trigonoine C(7)isolated from Trigonostemon lii.Their structures were...; 关键词：Trigonostemon filipes Trigonostemon lii β-carboline alkaloids trifilines A-C trigonoine C

Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells被引量：23: 《Cell Research》2011年第10期1424-1435,共12页Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie; Somatic cells can be reprogrammed into induced pluripotent stem cells （iPSCs） by defined factors. The low efficiency of reprogramming and genomic integration of oncogenes and viral vectors limited the potential appl...; 关键词：LITHIUM induced pluripotent stem cells IPS GSK3Β NANOG LSDI histone demethylase

国家重点基础研究发展计划(2009CB940900)