This work is supported in part by grants from Ministry of Sci- ence and Technology of China (2010CB945600, 2011CB966200), National Natural Science Foundation of China, the Special Project for Infection Disease (2008ZX10002-019), New Drug Development and Program of Shanghai Subject Chief Scien-tists (10XD1405400).
Aim: Osteopontin (OPN), a multifunctional protein, has been reported to be protoxicant in acetaminophen hepatotoxicity. In this study, the mechanisms underlying the detrimental role of OPN in acetaminophen toxicity...